FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128853119> ?p ?o ?g. }

• W3128853119 abstract "Abstract Both non-small-cell lung cancer cases in never-smokers and nonmedullary thyroid cancer cases have been increasing in developed countries. Some studies have shown an excess of co-occurrence of non-small-cell lung cancer and nonmedullary thyroid cancer. We aimed to clarify the underlying genetic factors that contribute to the occurrence of these two malignancies. We performed germline exome sequencing in a cohort of 9 patients with the two malignancies. In terms of candidate genes, we performed target resequencing, immunohistochemistry, and microsatellite instability testing on another cohort. Two rare missense heterozygous variants in MSH6 were identified and verified by Sanger sequencing. One available tumour specimen showed heterogeneous MSH6 status in immunohistochemistry. Further exploration with different cohorts (a total of 8 patients with the two malignancies) demonstrated that 2 out of 8 patients had a germline missense or promotor variant of MLH1 and four out of 10 tumour specimens revealed heterogeneous immunohistochemistry staining in any of the four mismatch repair proteins: MLH1, PMS2, MSH2 and MSH6. Although our cohort showed a different disease profile than Lynch syndrome, this study suggests causal roles of impaired DNA mismatch repair capacity in non-small-cell lung cancer and nonmedullary thyroid cancer." @default.
• W3128853119 created "2021-02-15" @default.
• W3128853119 creator A5000653374 @default.
• W3128853119 creator A5044441003 @default.
• W3128853119 date "2021-02-11" @default.
• W3128853119 modified "2023-09-23" @default.
• W3128853119 title "Alteration of DNA mismatch repair capacity underlying the co-occurrence of non-small-cell lung cancer and nonmedullary thyroid cancer" @default.
• W3128853119 cites W1516779141 @default.
• W3128853119 cites W1895151113 @default.
• W3128853119 cites W1967725159 @default.
• W3128853119 cites W1979927933 @default.
• W3128853119 cites W1980178943 @default.
• W3128853119 cites W1993611676 @default.
• W3128853119 cites W1993885354 @default.
• W3128853119 cites W1998087959 @default.
• W3128853119 cites W2002737460 @default.
• W3128853119 cites W2017784546 @default.
• W3128853119 cites W2043840480 @default.
• W3128853119 cites W2047524584 @default.
• W3128853119 cites W2071392860 @default.
• W3128853119 cites W2093733641 @default.
• W3128853119 cites W2095644224 @default.
• W3128853119 cites W2096465116 @default.
• W3128853119 cites W2120240963 @default.
• W3128853119 cites W2123016804 @default.
• W3128853119 cites W2140832617 @default.
• W3128853119 cites W2152072629 @default.
• W3128853119 cites W2157285258 @default.
• W3128853119 cites W2157334646 @default.
• W3128853119 cites W2161069860 @default.
• W3128853119 cites W2166592024 @default.
• W3128853119 cites W2181398779 @default.
• W3128853119 cites W2472596403 @default.
• W3128853119 cites W2582585407 @default.
• W3128853119 cites W2614521205 @default.
• W3128853119 cites W2618158839 @default.
• W3128853119 cites W2622499649 @default.
• W3128853119 cites W2724116530 @default.
• W3128853119 cites W2759156549 @default.
• W3128853119 cites W2785259638 @default.
• W3128853119 cites W2804394832 @default.
• W3128853119 cites W2889646458 @default.
• W3128853119 cites W2899144445 @default.
• W3128853119 cites W2937947516 @default.
• W3128853119 cites W2951438828 @default.
• W3128853119 cites W3029661147 @default.
• W3128853119 cites W2615040850 @default.
• W3128853119 doi "https://doi.org/10.1038/s41598-021-83177-1" @default.
• W3128853119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7878500" @default.
• W3128853119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33574476" @default.
• W3128853119 hasPublicationYear "2021" @default.
• W3128853119 type Work @default.
• W3128853119 sameAs 3128853119 @default.
• W3128853119 citedByCount "5" @default.
• W3128853119 countsByYear W31288531192021 @default.
• W3128853119 countsByYear W31288531192022 @default.
• W3128853119 countsByYear W31288531192023 @default.
• W3128853119 crossrefType "journal-article" @default.
• W3128853119 hasAuthorship W3128853119A5000653374 @default.
• W3128853119 hasAuthorship W3128853119A5044441003 @default.
• W3128853119 hasBestOaLocation W31288531191 @default.
• W3128853119 hasConcept C104317684 @default.
• W3128853119 hasConcept C111425858 @default.
• W3128853119 hasConcept C121608353 @default.
• W3128853119 hasConcept C126322002 @default.
• W3128853119 hasConcept C142724271 @default.
• W3128853119 hasConcept C143998085 @default.
• W3128853119 hasConcept C16671776 @default.
• W3128853119 hasConcept C180754005 @default.
• W3128853119 hasConcept C2776256026 @default.
• W3128853119 hasConcept C2776674815 @default.
• W3128853119 hasConcept C2778677574 @default.
• W3128853119 hasConcept C2779115348 @default.
• W3128853119 hasConcept C2779761222 @default.
• W3128853119 hasConcept C2779767149 @default.
• W3128853119 hasConcept C501734568 @default.
• W3128853119 hasConcept C502942594 @default.
• W3128853119 hasConcept C526805850 @default.
• W3128853119 hasConcept C54355233 @default.
• W3128853119 hasConcept C60748783 @default.
• W3128853119 hasConcept C61320498 @default.
• W3128853119 hasConcept C71924100 @default.
• W3128853119 hasConcept C86803240 @default.
• W3128853119 hasConceptScore W3128853119C104317684 @default.
• W3128853119 hasConceptScore W3128853119C111425858 @default.
• W3128853119 hasConceptScore W3128853119C121608353 @default.
• W3128853119 hasConceptScore W3128853119C126322002 @default.
• W3128853119 hasConceptScore W3128853119C142724271 @default.
• W3128853119 hasConceptScore W3128853119C143998085 @default.
• W3128853119 hasConceptScore W3128853119C16671776 @default.
• W3128853119 hasConceptScore W3128853119C180754005 @default.
• W3128853119 hasConceptScore W3128853119C2776256026 @default.
• W3128853119 hasConceptScore W3128853119C2776674815 @default.
• W3128853119 hasConceptScore W3128853119C2778677574 @default.
• W3128853119 hasConceptScore W3128853119C2779115348 @default.
• W3128853119 hasConceptScore W3128853119C2779761222 @default.
• W3128853119 hasConceptScore W3128853119C2779767149 @default.
• W3128853119 hasConceptScore W3128853119C501734568 @default.
• W3128853119 hasConceptScore W3128853119C502942594 @default.
• W3128853119 hasConceptScore W3128853119C526805850 @default.

• next