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- W3128868967 abstract "The human APOBEC3A (A3A) polynucleotide cytidine deaminase has been shown to have antiviral activity against HTLV-1 but not HIV-1, when expressed in the virus producer cell. In viral target cells, high levels of endogenous A3A activity have been associated with the restriction of HIV-1 during infection. Here we demonstrate that A3A derived from both target cells and producer cells can block the infection of Moloney-MLV (MLV) and related AKV-derived strains of MLV in a deaminase-dependent mode. Furthermore, glycosylated Gag (glycoGag) of MLV inhibits the encapsidation of human A3A, but target cell A3A was not affected by glycoGag and exerted deamination of viral DNA. Importantly, our results clearly indicate that poor glycoGag expression in MLV gag-pol packaging constructs as compared to abundant levels in full-length amphotropic MLV makes these viral vectors sensitive to A3A-mediated restriction. This raises the possibility of acquiring A3A-induced mutations in retroviral gene therapy applications." @default.
- W3128868967 created "2021-02-15" @default.
- W3128868967 creator A5000874547 @default.
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- W3128868967 creator A5051816392 @default.
- W3128868967 creator A5068260594 @default.
- W3128868967 creator A5086888386 @default.
- W3128868967 date "2021-05-01" @default.
- W3128868967 modified "2023-09-24" @default.
- W3128868967 title "Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A" @default.
- W3128868967 cites W1515041121 @default.
- W3128868967 cites W1559282072 @default.
- W3128868967 cites W1570782185 @default.
- W3128868967 cites W1851544526 @default.
- W3128868967 cites W1933898011 @default.
- W3128868967 cites W1963594716 @default.
- W3128868967 cites W1964567249 @default.
- W3128868967 cites W1966343819 @default.
- W3128868967 cites W1967384725 @default.
- W3128868967 cites W1974822696 @default.
- W3128868967 cites W1977012657 @default.
- W3128868967 cites W1977239712 @default.
- W3128868967 cites W1978118673 @default.
- W3128868967 cites W1978920270 @default.
- W3128868967 cites W1979609757 @default.
- W3128868967 cites W1980703118 @default.
- W3128868967 cites W1981544157 @default.
- W3128868967 cites W1984236815 @default.
- W3128868967 cites W1984933368 @default.
- W3128868967 cites W1988960099 @default.
- W3128868967 cites W1990080035 @default.
- W3128868967 cites W1991069890 @default.
- W3128868967 cites W1992007798 @default.
- W3128868967 cites W1992084137 @default.
- W3128868967 cites W1992127199 @default.
- W3128868967 cites W1992984336 @default.
- W3128868967 cites W1993897877 @default.
- W3128868967 cites W1996737758 @default.
- W3128868967 cites W1997345818 @default.
- W3128868967 cites W2000620255 @default.
- W3128868967 cites W2001691654 @default.
- W3128868967 cites W2003665515 @default.
- W3128868967 cites W2004640739 @default.
- W3128868967 cites W2006699168 @default.
- W3128868967 cites W2008684414 @default.
- W3128868967 cites W2012564250 @default.
- W3128868967 cites W2012986173 @default.
- W3128868967 cites W2023035407 @default.
- W3128868967 cites W2025326369 @default.
- W3128868967 cites W2027983183 @default.
- W3128868967 cites W2029884547 @default.
- W3128868967 cites W2033218403 @default.
- W3128868967 cites W2033631070 @default.
- W3128868967 cites W2035395679 @default.
- W3128868967 cites W2042486230 @default.
- W3128868967 cites W2042651904 @default.
- W3128868967 cites W2043444520 @default.
- W3128868967 cites W2044553096 @default.
- W3128868967 cites W2045628835 @default.
- W3128868967 cites W2045924690 @default.
- W3128868967 cites W2048538015 @default.
- W3128868967 cites W2049725192 @default.
- W3128868967 cites W2050613958 @default.
- W3128868967 cites W2051173965 @default.
- W3128868967 cites W2054310224 @default.
- W3128868967 cites W2054437592 @default.
- W3128868967 cites W2055662683 @default.
- W3128868967 cites W2056834613 @default.
- W3128868967 cites W2059399597 @default.
- W3128868967 cites W2062378658 @default.
- W3128868967 cites W2062855385 @default.
- W3128868967 cites W2063337242 @default.
- W3128868967 cites W2063525329 @default.
- W3128868967 cites W2064424928 @default.
- W3128868967 cites W2065470506 @default.
- W3128868967 cites W2066400897 @default.
- W3128868967 cites W2067387759 @default.
- W3128868967 cites W2069554621 @default.
- W3128868967 cites W2070780294 @default.
- W3128868967 cites W2074958524 @default.
- W3128868967 cites W2076559238 @default.
- W3128868967 cites W2080366675 @default.
- W3128868967 cites W2084938297 @default.
- W3128868967 cites W2085458745 @default.
- W3128868967 cites W2086636233 @default.
- W3128868967 cites W2096197897 @default.
- W3128868967 cites W2096783891 @default.
- W3128868967 cites W2098991785 @default.
- W3128868967 cites W2099881609 @default.
- W3128868967 cites W2104298833 @default.
- W3128868967 cites W2104808073 @default.
- W3128868967 cites W2105657544 @default.
- W3128868967 cites W2108018617 @default.
- W3128868967 cites W2108623691 @default.
- W3128868967 cites W2110692613 @default.
- W3128868967 cites W2112503642 @default.