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- W3128889398 abstract "The influence of the G-quartet structural integrity on the catalytic activity of the G-quadruplex (G4) was investigated by comparing the G4-DNAzyme performances of a series of G4s with a G-vacancy site and a G-triplex (G-tri). The results presented herein not only confirm that the structural integrity of the 3’-end G-quartet is necessary for G4s to be catalytically competent but also show how to remediate G-vacancy-mediated catalytic activity losses via the addition of guanine surrogates in an approach referred to as G-vacancy complementation strategy that is applicable to parallel G4s only. Furthermore, this study demonstrates that the terminal G-quartet could act as a proximal coordinating group and cooperate with the flanking nucleotide to activate the hemin cofactor." @default.
- W3128889398 created "2021-02-15" @default.
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- W3128889398 date "2021-07-01" @default.
- W3128889398 modified "2023-10-16" @default.
- W3128889398 title "The catalytic properties of DNA G-quadruplexes rely on their structural integrity" @default.
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- W3128889398 doi "https://doi.org/10.1016/s1872-2067(20)63744-5" @default.
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