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- W3128901650 abstract "During the past few decades, considerable efforts have been made to discover and validate new molecular mechanisms and biomarkers of neurodegenerative diseases. Recent discoveries have demonstrated how autophagy and its specialized form mitophagy are extensively associated with the development, maintenance, and progression of several neurodegenerative diseases. These mechanisms play a pivotal role in the homeostasis of neural cells and are responsible for the clearance of intracellular aggregates and misfolded proteins and the turnover of organelles, in particular, mitochondria. In this review, we summarize recent advances describing the importance of autophagy and mitophagy in neurodegenerative diseases, with particular attention given to multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. We also review how elements involved in autophagy and mitophagy may represent potential biomarkers for these common neurodegenerative diseases. Finally, we examine the possibility that the modulation of autophagic and mitophagic mechanisms may be an innovative strategy for overcoming neurodegenerative conditions. A deeper knowledge of autophagic and mitophagic mechanisms could facilitate diagnosis and prognostication as well as accelerate the development of therapeutic strategies for neurodegenerative diseases." @default.
- W3128901650 created "2021-02-15" @default.
- W3128901650 creator A5017121033 @default.
- W3128901650 creator A5025384906 @default.
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- W3128901650 creator A5052329484 @default.
- W3128901650 creator A5070894673 @default.
- W3128901650 creator A5086468991 @default.
- W3128901650 date "2021-02-04" @default.
- W3128901650 modified "2023-10-17" @default.
- W3128901650 title "Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases" @default.
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