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- W3128958045 abstract "Mammalian target of rapamycin (mTOR), as an axial mediator of multiple cell growth pathways, is in connection withseveral other proteins that are involved in the regulation of homeostasis in the cell function. mTOR’s signaling pathwayparticipates in and integrates a variety of environmental cues to control cancer cell and normal tissue development. mTORand its inhibitors including the rapamycin analogues are attractive therapeutic indication to clinical trials for treatingvarious types of cancers, with or without inhibitors of other signaling pathways. Despite the promising results in cancertreatment, low water solubility of rapamycin is shown to decrease its therapeutic efficacy. To reach an acceptable level ofefficacy, high distribution and accepted dispersing of utilized drugs in control of mTOR signaling pathway, nanomaterialsbased drug delivery can play an important role. Evaluation of the mechanisms and therapeutic effects of nanoparticle-basedmTOR modulation can be useful in developing safe strategies in treatment of cancer. Regarding the clinical importance ofmTOR deregulation in human diseases, hereby, we address the recent progress in the field of nanoparticle-based mTORtargeted therapy." @default.
- W3128958045 created "2021-02-15" @default.
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- W3128958045 date "2018-01-01" @default.
- W3128958045 modified "2023-10-16" @default.
- W3128958045 title "Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology" @default.
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