FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128971131> ?p ?o ?g. }

• W3128971131 abstract "Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed as a potential therapeutic intervention in psychiatric disorders. However, following intranasal administration, oxytocin could penetrate directly into the brain or influence its activity via increased peripheral concentrations crossing the blood-brain barrier or influencing vagal projections. In the current randomized, placebo-controlled, pharmaco-imaging clinical trial we investigated effects of 24IU oral (lingual) oxytocin spray, restricting it to peripherally mediated blood-borne and vagal effects, on responses to face emotions in 80 male subjects and compared them with 138 subjects treated intranasally with 24IU. Oral, but not intranasal oxytocin administration increased both arousal ratings for faces and associated brain reward responses, the latter being partially mediated by blood concentration changes. Furthermore, while oral oxytocin increased amygdala and arousal responses to face emotions, after intranasal administration they were decreased. Thus, oxytocin can produce markedly contrasting motivational effects in relation to socioemotional cues when it influences brain function via different routes. These findings have important implications for future therapeutic use since administering oxytocin orally may be both easier and have potentially stronger beneficial effects by enhancing responses to emotional cues and increasing their associated reward." @default.
• W3128971131 created "2021-02-15" @default.
• W3128971131 creator A5000445902 @default.
• W3128971131 creator A5020130807 @default.
• W3128971131 creator A5022713595 @default.
• W3128971131 creator A5038771100 @default.
• W3128971131 creator A5044395226 @default.
• W3128971131 creator A5062755510 @default.
• W3128971131 creator A5064007420 @default.
• W3128971131 creator A5065236570 @default.
• W3128971131 creator A5078936001 @default.
• W3128971131 creator A5090086041 @default.
• W3128971131 date "2021-02-04" @default.
• W3128971131 modified "2023-09-23" @default.
• W3128971131 title "In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing" @default.
• W3128971131 cites W1630835083 @default.
• W3128971131 cites W1750764127 @default.
• W3128971131 cites W1835051027 @default.
• W3128971131 cites W1974789834 @default.
• W3128971131 cites W1990134753 @default.
• W3128971131 cites W2021223630 @default.
• W3128971131 cites W2023636464 @default.
• W3128971131 cites W2036441276 @default.
• W3128971131 cites W2038702827 @default.
• W3128971131 cites W2043628043 @default.
• W3128971131 cites W2049473251 @default.
• W3128971131 cites W2062508009 @default.
• W3128971131 cites W2070420735 @default.
• W3128971131 cites W2080326011 @default.
• W3128971131 cites W2093922373 @default.
• W3128971131 cites W2095069422 @default.
• W3128971131 cites W2112699212 @default.
• W3128971131 cites W2115046242 @default.
• W3128971131 cites W2116649573 @default.
• W3128971131 cites W2121748618 @default.
• W3128971131 cites W2124961114 @default.
• W3128971131 cites W2127553159 @default.
• W3128971131 cites W2146224339 @default.
• W3128971131 cites W2148905283 @default.
• W3128971131 cites W2155600799 @default.
• W3128971131 cites W2167450905 @default.
• W3128971131 cites W2169463832 @default.
• W3128971131 cites W2202540184 @default.
• W3128971131 cites W2235676486 @default.
• W3128971131 cites W2341490827 @default.
• W3128971131 cites W2402346616 @default.
• W3128971131 cites W2414463305 @default.
• W3128971131 cites W2463712686 @default.
• W3128971131 cites W2520003619 @default.
• W3128971131 cites W2566979214 @default.
• W3128971131 cites W2605316979 @default.
• W3128971131 cites W2613162307 @default.
• W3128971131 cites W2724271447 @default.
• W3128971131 cites W2751943248 @default.
• W3128971131 cites W2752598420 @default.
• W3128971131 cites W2805000670 @default.
• W3128971131 cites W2808328764 @default.
• W3128971131 cites W2809468983 @default.
• W3128971131 cites W2855856887 @default.
• W3128971131 cites W2915217457 @default.
• W3128971131 cites W2952917574 @default.
• W3128971131 cites W2962935712 @default.
• W3128971131 cites W2980472889 @default.
• W3128971131 cites W2990413784 @default.
• W3128971131 cites W3006553795 @default.
• W3128971131 cites W3009941151 @default.
• W3128971131 cites W3016418246 @default.
• W3128971131 cites W3031412498 @default.
• W3128971131 cites W3049568087 @default.
• W3128971131 cites W4230547082 @default.
• W3128971131 cites W4292994367 @default.
• W3128971131 cites W4231082634 @default.
• W3128971131 doi "https://doi.org/10.1038/s41398-021-01241-w" @default.
• W3128971131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7862637" @default.
• W3128971131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33542175" @default.
• W3128971131 hasPublicationYear "2021" @default.
• W3128971131 type Work @default.
• W3128971131 sameAs 3128971131 @default.
• W3128971131 citedByCount "18" @default.
• W3128971131 countsByYear W31289711312021 @default.
• W3128971131 countsByYear W31289711312022 @default.
• W3128971131 countsByYear W31289711312023 @default.
• W3128971131 crossrefType "journal-article" @default.
• W3128971131 hasAuthorship W3128971131A5000445902 @default.
• W3128971131 hasAuthorship W3128971131A5020130807 @default.
• W3128971131 hasAuthorship W3128971131A5022713595 @default.
• W3128971131 hasAuthorship W3128971131A5038771100 @default.
• W3128971131 hasAuthorship W3128971131A5044395226 @default.
• W3128971131 hasAuthorship W3128971131A5062755510 @default.
• W3128971131 hasAuthorship W3128971131A5064007420 @default.
• W3128971131 hasAuthorship W3128971131A5065236570 @default.
• W3128971131 hasAuthorship W3128971131A5078936001 @default.
• W3128971131 hasAuthorship W3128971131A5090086041 @default.
• W3128971131 hasBestOaLocation W31289711311 @default.
• W3128971131 hasConcept C101595628 @default.
• W3128971131 hasConcept C118552586 @default.
• W3128971131 hasConcept C15744967 @default.
• W3128971131 hasConcept C169760540 @default.
• W3128971131 hasConcept C2776176026 @default.
• W3128971131 hasConcept C2776412080 @default.

• next