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- W3129046985 abstract "Atherosclerosis demonstrates an increased rate of vascular smooth muscle cells (VSMC) plasticity characterized by switching from the differentiated contractile phenotype to a de-differentiated synthetic state. In healthy blood vessels, phenotypic switching represents a fundamental property of VSMC in maintaining vascular homeostasis. However, in atherosclerosis, it is an initial and necessary step in VSMC-derived foam cell formation. These foam cells play a decisive role in atherosclerosis progression since approximately half of all the foam cells are of VSMC origin. Our recent work showed that interferon-gamma (IFN-γ), a primary inflammatory cytokine in progressive atherosclerosis, mediates VSMC phenotype switching exclusively through upregulating mini-tryptophanyl-tRNA synthetase (mini-TrpRS). Here, we discuss the pro-atherosclerotic implication of this phenomenon that inevitably occurs in the context of a more complex regulation mediated by IFN-γ. An emerging therapeutic option for patients with progressive atherosclerosis is also discussed." @default.
- W3129046985 created "2021-02-15" @default.
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- W3129046985 date "2022-04-01" @default.
- W3129046985 modified "2023-09-30" @default.
- W3129046985 title "Role of inflammatory cytokines in genesis and treatment of atherosclerosis" @default.
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- W3129046985 doi "https://doi.org/10.1016/j.tcm.2021.02.001" @default.
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