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- W3129065280 endingPage "669" @default.
- W3129065280 startingPage "669" @default.
- W3129065280 abstract "It is well recognized today that anticancer drugs often are most effective when used in combination. However, the establishment of chemotherapy as key modality in clinical oncology began with sporadic discoveries of chemicals that showed antiproliferative properties and which as a first attempt were used as single agents. In this review we describe the development of chemotherapy from its origins as a single drug treatment with cytotoxic agents to polydrug therapy that includes targeted drugs. We discuss the limitations of the first chemotherapeutic drugs as a motivation for the establishment of combined drug treatment as standard practice in spite of concerns about frequent severe, dose limiting toxicities. Next, we introduce the development of targeted treatment as a concept for advancement within the broader field of small-molecule drug combination therapy in cancer and its accelerating progress that was boosted by recent scientific and technological progresses. Finally, we describe an alternative strategy of drug combinations using drug-conjugates for selective delivery of cytotoxic drugs to tumor cells that potentiates future improvement of drug combinations in cancer treatment. Overall, in this review we outline the development of chemotherapy from a pharmacological perspective, from its early stages to modern concepts of using targeted therapies for combinational treatment." @default.
- W3129065280 created "2021-02-15" @default.
- W3129065280 creator A5003310357 @default.
- W3129065280 creator A5056985040 @default.
- W3129065280 creator A5057978718 @default.
- W3129065280 creator A5069521918 @default.
- W3129065280 date "2021-02-07" @default.
- W3129065280 modified "2023-10-02" @default.
- W3129065280 title "Drug Combination in Cancer Treatment—From Cocktails to Conjugated Combinations" @default.
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