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- W3129078717 endingPage "1719" @default.
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- W3129078717 abstract "Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits and blockade of A2AR enhances D2R-mediated locomotor activation and goal-directed behavior in rodents. In striatal membrane preparations, adenosine decreases both the affinity and the signal transduction of D2R via its interaction with A2AR. Reciprocal A2AR/D2R interactions occur mainly in striatopallidal GABAergic medium spiny neurons (MSNs) of the indirect pathway that are involved in motor control, and in striatal astrocytes. In the nucleus accumbens, they also take place in MSNs involved in reward-related behavior. A2AR and D2R co-aggregate, co-internalize, and co-desensitize. They are at very close distance in biomembranes and form heteromers. Antagonistic interactions between adenosine and dopamine are (at least partially) caused by allosteric receptor–receptor interactions within A2AR/D2R heteromeric complexes. Such interactions may be exploited in novel strategies for the treatment of Parkinson’s disease, schizophrenia, substance abuse, and perhaps also attention deficit-hyperactivity disorder. Little is known about shifting A2AR/D2R heteromer/homodimer equilibria in the brain. Positron emission tomography with suitable ligands may provide in vivo information about receptor crosstalk in the living organism. Some experimental approaches, and strategies for the design of novel imaging agents (e.g., heterobivalent ligands) are proposed in this review." @default.
- W3129078717 created "2021-02-15" @default.
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- W3129078717 creator A5063250977 @default.
- W3129078717 date "2021-02-09" @default.
- W3129078717 modified "2023-09-27" @default.
- W3129078717 title "Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging" @default.
- W3129078717 cites W138735910 @default.
- W3129078717 cites W1493115321 @default.
- W3129078717 cites W1501384344 @default.
- W3129078717 cites W1502439265 @default.
- W3129078717 cites W1524422898 @default.
- W3129078717 cites W1548690558 @default.
- W3129078717 cites W1550887894 @default.
- W3129078717 cites W1575549368 @default.
- W3129078717 cites W1636386427 @default.
- W3129078717 cites W1676635233 @default.
- W3129078717 cites W1713613443 @default.
- W3129078717 cites W1837235659 @default.
- W3129078717 cites W1844553425 @default.
- W3129078717 cites W1884206649 @default.
- W3129078717 cites W1925945475 @default.
- W3129078717 cites W1965036463 @default.
- W3129078717 cites W1965280907 @default.
- W3129078717 cites W1965941138 @default.
- W3129078717 cites W1968443196 @default.
- W3129078717 cites W1968481114 @default.
- W3129078717 cites W1969602480 @default.
- W3129078717 cites W1970073512 @default.
- W3129078717 cites W1972232046 @default.
- W3129078717 cites W1973037117 @default.
- W3129078717 cites W1973335238 @default.
- W3129078717 cites W1974702611 @default.
- W3129078717 cites W1975418040 @default.
- W3129078717 cites W1975863542 @default.
- W3129078717 cites W1975915682 @default.
- W3129078717 cites W1977233750 @default.
- W3129078717 cites W1978186008 @default.
- W3129078717 cites W1978301891 @default.
- W3129078717 cites W1978647688 @default.
- W3129078717 cites W1980678191 @default.
- W3129078717 cites W1981480470 @default.
- W3129078717 cites W1982827121 @default.
- W3129078717 cites W1983415204 @default.
- W3129078717 cites W1985156573 @default.
- W3129078717 cites W1986174590 @default.
- W3129078717 cites W1986583148 @default.
- W3129078717 cites W1987091049 @default.
- W3129078717 cites W1987741625 @default.
- W3129078717 cites W1988290493 @default.
- W3129078717 cites W1989228121 @default.
- W3129078717 cites W1989831607 @default.
- W3129078717 cites W1990269363 @default.
- W3129078717 cites W1991263244 @default.
- W3129078717 cites W1991603311 @default.
- W3129078717 cites W1991771347 @default.
- W3129078717 cites W1991863073 @default.
- W3129078717 cites W1992496728 @default.
- W3129078717 cites W1992815150 @default.
- W3129078717 cites W1992919799 @default.
- W3129078717 cites W1993560199 @default.
- W3129078717 cites W1994863571 @default.
- W3129078717 cites W1995387616 @default.
- W3129078717 cites W1996013558 @default.
- W3129078717 cites W1996056860 @default.
- W3129078717 cites W1997485587 @default.
- W3129078717 cites W1997586459 @default.
- W3129078717 cites W1998013279 @default.
- W3129078717 cites W1998328076 @default.
- W3129078717 cites W1999554002 @default.
- W3129078717 cites W2000263684 @default.
- W3129078717 cites W2000939164 @default.
- W3129078717 cites W2001142399 @default.
- W3129078717 cites W2003336656 @default.
- W3129078717 cites W2004541711 @default.
- W3129078717 cites W2005124077 @default.
- W3129078717 cites W2005146491 @default.
- W3129078717 cites W2005530101 @default.
- W3129078717 cites W2006293323 @default.
- W3129078717 cites W2006331600 @default.
- W3129078717 cites W2006411423 @default.
- W3129078717 cites W2006537215 @default.
- W3129078717 cites W2006715508 @default.
- W3129078717 cites W2006983044 @default.
- W3129078717 cites W2007254896 @default.
- W3129078717 cites W2007577290 @default.
- W3129078717 cites W2008455295 @default.
- W3129078717 cites W2008871586 @default.
- W3129078717 cites W2009538078 @default.
- W3129078717 cites W2009591333 @default.
- W3129078717 cites W2009676467 @default.
- W3129078717 cites W2009868913 @default.
- W3129078717 cites W2010561013 @default.
- W3129078717 cites W2011649118 @default.
- W3129078717 cites W2012356934 @default.