FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129087870> ?p ?o ?g. }

• W3129087870 endingPage "153500" @default.
• W3129087870 startingPage "153500" @default.
• W3129087870 abstract "A large number of breast cancer patients perishes due to metastasis instead of primary tumor, but molecular mechanisms contributing towards cancer metastasis remain poorly understood. Therefore, prompting development of novel treatment is inevitable. A vast variety of plant derived natural substance possesses several therapeutically active constituents, e.g. alkaloids, flavonoids, tannins, resins, terpenoids etc. that exhibit various pharmacological properties e.g. anti-inflammatory, anti-microbial and anti-cancer properties. Sanguinarine (SAN) alkaloid found its place among such naturally occurring substances that exerts several pharmacological activities, including anti-cancer effects. Until now, role of SAN not only against epithelial-mesenchymal transition (EMT) but also against metastasis progression in breast cancer remains indistinct. Thus, aim of the present study was to investigate effects of SAN on EMT process and cancer metastasis in animal model. MTT assay was performed to assess SAN effects on proliferation in breast cancer. Scratch assay was performed to evaluate effects of SAN on migration in breast cancer. Colony formation assay was performed to determine effects of SAN on colonization characteristics of breast cancer. Western blotting was performed to measure EMT regulating protein expression as well as major pathway protein expression induced against TGF-β treatment in breast cancer. Tail vein method of injecting breast cancer cells in bulb/c mice was conducted to study metastasis progression and thereafter assessing effects of SAN against metastasis in mice. In vivo results: MTT assay performed, demonstrated dose dependent inhibition of cell proliferation in breast cancer. Scratch assay results showed, SAN played a major role as migration inhibitor in estrogen receptor positive (ER+) breast cancer. Colony forming assay results demonstrated that SAN constrains ability of breast cancer to develop into well-defined colonies. Western blotting results for EMT regulating protein expression, after TGF-β treatment showed, SAN inhibited cadherin switch in ER+ breast cancer. Moreover, expression of pathway proteins involved in EMT process after TGF-β treatment i.e. Smad, PI3K/Akt and MAP kinase were significantly masked against SAN treatment. The appearance of metastatic nodules in lung tissues of mice model, helps to study the effects of SAN against metastasis in bulb/c mice. The obtained results have confirmed that SAN impeded lung metastasis. The macroscopic examination has confirmed metastasis inhibitory role of SAN in breast cancer. The Hematoxylin and eosin (H&E) staining results further advocate anti-metastatic characteristics of SAN, presented by fewer metastatic nodule and lesions appearance in SAN treated mice compared to untreated metastasis mice. In summary, SAN displayed prominent anti-metastatic effects in animal model and anti-proliferation effects together with significant inhibitory potential on EMT regulating protein expression against TGF-β treatment in ER+ breast cancer. So, overall findings of our study highlighted the pre-clinical significance of SAN in animal model therefore, further studies in humans as a part of clinical trial will be needed to establish pharmacokinetics and other effects of SAN, so that it can be a potential candidate for future treatment of metastatic breast cancer (MBC)." @default.
• W3129087870 created "2021-02-15" @default.
• W3129087870 creator A5034525614 @default.
• W3129087870 creator A5037481250 @default.
• W3129087870 creator A5042325449 @default.
• W3129087870 creator A5046822662 @default.
• W3129087870 creator A5061354710 @default.
• W3129087870 creator A5066930734 @default.
• W3129087870 creator A5074392232 @default.
• W3129087870 creator A5083069101 @default.
• W3129087870 date "2021-04-01" @default.
• W3129087870 modified "2023-10-10" @default.
• W3129087870 title "Sanguinarine impedes metastasis and causes inversion of epithelial to mesenchymal transition in breast cancer" @default.
• W3129087870 cites W1037161726 @default.
• W3129087870 cites W2022576539 @default.
• W3129087870 cites W2029624836 @default.
• W3129087870 cites W2045876788 @default.
• W3129087870 cites W2085895809 @default.
• W3129087870 cites W2099449365 @default.
• W3129087870 cites W2104335315 @default.
• W3129087870 cites W2274805782 @default.
• W3129087870 cites W2470036731 @default.
• W3129087870 cites W2583126643 @default.
• W3129087870 cites W2586379207 @default.
• W3129087870 cites W2742211392 @default.
• W3129087870 cites W2799771420 @default.
• W3129087870 cites W2889646458 @default.
• W3129087870 cites W2911188335 @default.
• W3129087870 cites W2954894548 @default.
• W3129087870 cites W2992433783 @default.
• W3129087870 cites W2996109785 @default.
• W3129087870 cites W3006607092 @default.
• W3129087870 cites W3017703621 @default.
• W3129087870 cites W3024568857 @default.
• W3129087870 cites W3092243476 @default.
• W3129087870 cites W4252714226 @default.
• W3129087870 doi "https://doi.org/10.1016/j.phymed.2021.153500" @default.
• W3129087870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33626427" @default.
• W3129087870 hasPublicationYear "2021" @default.
• W3129087870 type Work @default.
• W3129087870 sameAs 3129087870 @default.
• W3129087870 citedByCount "15" @default.
• W3129087870 countsByYear W31290878702021 @default.
• W3129087870 countsByYear W31290878702022 @default.
• W3129087870 countsByYear W31290878702023 @default.
• W3129087870 crossrefType "journal-article" @default.
• W3129087870 hasAuthorship W3129087870A5034525614 @default.
• W3129087870 hasAuthorship W3129087870A5037481250 @default.
• W3129087870 hasAuthorship W3129087870A5042325449 @default.
• W3129087870 hasAuthorship W3129087870A5046822662 @default.
• W3129087870 hasAuthorship W3129087870A5061354710 @default.
• W3129087870 hasAuthorship W3129087870A5066930734 @default.
• W3129087870 hasAuthorship W3129087870A5074392232 @default.
• W3129087870 hasAuthorship W3129087870A5083069101 @default.
• W3129087870 hasConcept C121608353 @default.
• W3129087870 hasConcept C126322002 @default.
• W3129087870 hasConcept C2777667214 @default.
• W3129087870 hasConcept C2778046504 @default.
• W3129087870 hasConcept C2779013556 @default.
• W3129087870 hasConcept C2780783641 @default.
• W3129087870 hasConcept C502942594 @default.
• W3129087870 hasConcept C530470458 @default.
• W3129087870 hasConcept C55493867 @default.
• W3129087870 hasConcept C59822182 @default.
• W3129087870 hasConcept C62112901 @default.
• W3129087870 hasConcept C71924100 @default.
• W3129087870 hasConcept C76419328 @default.
• W3129087870 hasConcept C86803240 @default.
• W3129087870 hasConcept C96232424 @default.
• W3129087870 hasConceptScore W3129087870C121608353 @default.
• W3129087870 hasConceptScore W3129087870C126322002 @default.
• W3129087870 hasConceptScore W3129087870C2777667214 @default.
• W3129087870 hasConceptScore W3129087870C2778046504 @default.
• W3129087870 hasConceptScore W3129087870C2779013556 @default.
• W3129087870 hasConceptScore W3129087870C2780783641 @default.
• W3129087870 hasConceptScore W3129087870C502942594 @default.
• W3129087870 hasConceptScore W3129087870C530470458 @default.
• W3129087870 hasConceptScore W3129087870C55493867 @default.
• W3129087870 hasConceptScore W3129087870C59822182 @default.
• W3129087870 hasConceptScore W3129087870C62112901 @default.
• W3129087870 hasConceptScore W3129087870C71924100 @default.
• W3129087870 hasConceptScore W3129087870C76419328 @default.
• W3129087870 hasConceptScore W3129087870C86803240 @default.
• W3129087870 hasConceptScore W3129087870C96232424 @default.
• W3129087870 hasFunder F4320321001 @default.
• W3129087870 hasLocation W31290878701 @default.
• W3129087870 hasOpenAccess W3129087870 @default.
• W3129087870 hasPrimaryLocation W31290878701 @default.
• W3129087870 hasRelatedWork W2002597275 @default.
• W3129087870 hasRelatedWork W2295552376 @default.
• W3129087870 hasRelatedWork W2582912872 @default.
• W3129087870 hasRelatedWork W2789798659 @default.
• W3129087870 hasRelatedWork W2791305333 @default.
• W3129087870 hasRelatedWork W2901878811 @default.
• W3129087870 hasRelatedWork W3022866938 @default.
• W3129087870 hasRelatedWork W3022892502 @default.
• W3129087870 hasRelatedWork W3041026090 @default.
• W3129087870 hasRelatedWork W4304116770 @default.

• next