FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129088957> ?p ?o ?g. }

• W3129088957 endingPage "100298" @default.
• W3129088957 startingPage "100298" @default.
• W3129088957 abstract "Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with a higher risk of psychological disorders, including anxiety disorders and major depressive disorder (MDD). The orexinergic system is involved in the regulation of multiple motivated behaviors. The current study examined the regulatory effect of orexinergic projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) in depression- and anxiety-like behaviors after chronic social defeat stress. When mice were defeated during social interaction, both orexinergic neurons in the LHA and glutamatergic neurons in the LHb were strongly activated, as indicated by the FosTRAP strategy. Infusion of orexin in the LHb significantly alleviated social avoidance and depression-like behaviors induced by chronic social defeat stress. Administration of an orexin receptor 2 antagonist in the LHb further aggravated the depressive phenotype. Photoactivation of orexinergic cell bodies in the LHA or terminals in the LHb relieved anxiety-like behaviors induced by chronic social defeat stress. Collectively, we identified the antidepressant and anxiolytic effects of the circuit from LHA orexinergic neurons to the LHb in response to chronic social stress, providing new evidence of the antidepressant properties of LHA orexin circuits." @default.
• W3129088957 created "2021-02-15" @default.
• W3129088957 creator A5013509330 @default.
• W3129088957 creator A5017902704 @default.
• W3129088957 creator A5026475770 @default.
• W3129088957 creator A5035441171 @default.
• W3129088957 creator A5040208654 @default.
• W3129088957 creator A5040839623 @default.
• W3129088957 creator A5056342535 @default.
• W3129088957 creator A5058380236 @default.
• W3129088957 creator A5060671176 @default.
• W3129088957 creator A5079198496 @default.
• W3129088957 date "2021-05-01" @default.
• W3129088957 modified "2023-10-18" @default.
• W3129088957 title "Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress" @default.
• W3129088957 cites W1967998007 @default.
• W3129088957 cites W1968108222 @default.
• W3129088957 cites W1973808376 @default.
• W3129088957 cites W1977593923 @default.
• W3129088957 cites W1980363663 @default.
• W3129088957 cites W1984118082 @default.
• W3129088957 cites W1990605834 @default.
• W3129088957 cites W1991313750 @default.
• W3129088957 cites W1997017221 @default.
• W3129088957 cites W2005594217 @default.
• W3129088957 cites W2015550447 @default.
• W3129088957 cites W2024348439 @default.
• W3129088957 cites W2037702266 @default.
• W3129088957 cites W2041677480 @default.
• W3129088957 cites W2042180961 @default.
• W3129088957 cites W2047994705 @default.
• W3129088957 cites W2065060780 @default.
• W3129088957 cites W2091626580 @default.
• W3129088957 cites W2100800839 @default.
• W3129088957 cites W2104631706 @default.
• W3129088957 cites W2118659222 @default.
• W3129088957 cites W2135074291 @default.
• W3129088957 cites W2144101679 @default.
• W3129088957 cites W2152232087 @default.
• W3129088957 cites W2162444359 @default.
• W3129088957 cites W2338794286 @default.
• W3129088957 cites W2537084688 @default.
• W3129088957 cites W2593619809 @default.
• W3129088957 cites W2594369816 @default.
• W3129088957 cites W2597843544 @default.
• W3129088957 cites W2619887862 @default.
• W3129088957 cites W2754841759 @default.
• W3129088957 cites W2785523944 @default.
• W3129088957 cites W2785770559 @default.
• W3129088957 cites W2787343838 @default.
• W3129088957 cites W2795024927 @default.
• W3129088957 cites W2807073242 @default.
• W3129088957 cites W2808402994 @default.
• W3129088957 cites W2809035612 @default.
• W3129088957 cites W2883542372 @default.
• W3129088957 cites W2887786549 @default.
• W3129088957 cites W2889917493 @default.
• W3129088957 cites W2898537644 @default.
• W3129088957 cites W2906549751 @default.
• W3129088957 cites W2906786167 @default.
• W3129088957 cites W2910187702 @default.
• W3129088957 cites W2917178915 @default.
• W3129088957 cites W2946309156 @default.
• W3129088957 cites W2965161601 @default.
• W3129088957 cites W2971807108 @default.
• W3129088957 cites W3000408913 @default.
• W3129088957 cites W3000933107 @default.
• W3129088957 cites W3008796236 @default.
• W3129088957 cites W3015449951 @default.
• W3129088957 cites W3015690562 @default.
• W3129088957 cites W3015712098 @default.
• W3129088957 cites W3027768444 @default.
• W3129088957 cites W3047349122 @default.
• W3129088957 doi "https://doi.org/10.1016/j.ynstr.2021.100298" @default.
• W3129088957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7859368" @default.
• W3129088957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33569507" @default.
• W3129088957 hasPublicationYear "2021" @default.
• W3129088957 type Work @default.
• W3129088957 sameAs 3129088957 @default.
• W3129088957 citedByCount "25" @default.
• W3129088957 countsByYear W31290889572021 @default.
• W3129088957 countsByYear W31290889572022 @default.
• W3129088957 countsByYear W31290889572023 @default.
• W3129088957 crossrefType "journal-article" @default.
• W3129088957 hasAuthorship W3129088957A5013509330 @default.
• W3129088957 hasAuthorship W3129088957A5017902704 @default.
• W3129088957 hasAuthorship W3129088957A5026475770 @default.
• W3129088957 hasAuthorship W3129088957A5035441171 @default.
• W3129088957 hasAuthorship W3129088957A5040208654 @default.
• W3129088957 hasAuthorship W3129088957A5040839623 @default.
• W3129088957 hasAuthorship W3129088957A5056342535 @default.
• W3129088957 hasAuthorship W3129088957A5058380236 @default.
• W3129088957 hasAuthorship W3129088957A5060671176 @default.
• W3129088957 hasAuthorship W3129088957A5079198496 @default.
• W3129088957 hasBestOaLocation W31290889571 @default.
• W3129088957 hasConcept C118303440 @default.
• W3129088957 hasConcept C126322002 @default.
• W3129088957 hasConcept C137183658 @default.

• next