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- W3129096927 endingPage "1330" @default.
- W3129096927 startingPage "1330" @default.
- W3129096927 abstract "Understanding the cell differentiation process involves the characterization of signaling and regulatory pathways. The coordinated action involved in multilevel regulation determines the commitment of stem cells and their differentiation into a specific cell lineage. Cellular metabolism plays a relevant role in modulating the expression of genes, which act as sensors of the extra-and intracellular environment. In this work, we analyzed mRNAs associated with polysomes by focusing on the expression profile of metabolism-related genes during the cardiac differentiation of human embryonic stem cells (hESCs). We compared different time points during cardiac differentiation (pluripotency, embryoid body aggregation, cardiac mesoderm, cardiac progenitor and cardiomyocyte) and showed the immature cell profile of energy metabolism. Highly regulated canonical pathways are thoroughly discussed, such as those involved in metabolic signaling and lipid homeostasis. We reveal the critical relevance of retinoic X receptor (RXR) heterodimers in upstream retinoic acid metabolism and their relationship with thyroid hormone signaling. Additionally, we highlight the importance of lipid homeostasis and extracellular matrix component biosynthesis during cardiomyogenesis, providing new insights into how hESCs reorganize their metabolism during in vitro cardiac differentiation." @default.
- W3129096927 created "2021-02-15" @default.
- W3129096927 creator A5015983508 @default.
- W3129096927 creator A5042817059 @default.
- W3129096927 creator A5058422116 @default.
- W3129096927 creator A5068055395 @default.
- W3129096927 date "2021-01-29" @default.
- W3129096927 modified "2023-09-26" @default.
- W3129096927 title "Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation" @default.
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