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- W3129103650 abstract "Obstructive sleep apnea (OSA) is characterized as recurrent episodes of obstruction in the upper airway during the period of sleep. The condition occurs in approximately 11% and 4% of middle-aged men and middle-aged women, respectively. Polysomnography is a diagnostic procedure that involves the constant observation of oxygen saturation and unsaturation during sleep. Usually, positive airway pressure is considered a benchmark treatment for OSA. This review summarizes the recent developments and emerging evidence from molecular biology-based research studies that show that genetic factors have an influence on OSA. The genetic aspects of OSA that have been identified include heritability and other phenotypic co-factors such as anatomical morphology. It also draws attention to the results of a polymorphic-based study that was conducted to determine the causative single nucleotide mutations associated with obesity and adverse cardiovascular risk in OSA. However, the role of such mutations and their linkage to OSA can not yet be established. Nonetheless, a large body of evidence supports a strong association between inflammatory cytokine polymorphism and obesity in the development of OSA. There are also probable intermediate factors with several gene–gene interactions. Therefore, advanced applications and modern techniques should be applied to facilitate new findings and to minimize the risk of developing OSA. • Obesity and cardiovascular diseases predisposes to obstructive sleep apnea. • Molecular alterations determine the severity of obstructive sleep apnea. • Gene polymorphism is strongly associated with obstructive sleep apnea. • Molecular markers can aid to the management of obstructive sleep apnea." @default.
- W3129103650 created "2021-02-15" @default.
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- W3129103650 date "2021-04-01" @default.
- W3129103650 modified "2023-10-17" @default.
- W3129103650 title "Molecular determinants of obstructive sleep apnea" @default.
- W3129103650 cites W1486069605 @default.
- W3129103650 cites W1562392064 @default.
- W3129103650 cites W1964072032 @default.
- W3129103650 cites W1967598484 @default.
- W3129103650 cites W1975319022 @default.
- W3129103650 cites W1984921150 @default.
- W3129103650 cites W1988114644 @default.
- W3129103650 cites W1988546005 @default.
- W3129103650 cites W1991451916 @default.
- W3129103650 cites W1996678358 @default.
- W3129103650 cites W1996692474 @default.
- W3129103650 cites W2006915440 @default.
- W3129103650 cites W2007066741 @default.
- W3129103650 cites W2008992104 @default.
- W3129103650 cites W2012430427 @default.
- W3129103650 cites W2020142798 @default.
- W3129103650 cites W2024524548 @default.
- W3129103650 cites W2030392902 @default.
- W3129103650 cites W2032829106 @default.
- W3129103650 cites W2034556696 @default.
- W3129103650 cites W2036143978 @default.
- W3129103650 cites W2038345436 @default.
- W3129103650 cites W2047310683 @default.
- W3129103650 cites W2050733378 @default.
- W3129103650 cites W2050863893 @default.
- W3129103650 cites W2061193648 @default.
- W3129103650 cites W2062489262 @default.
- W3129103650 cites W2063135200 @default.
- W3129103650 cites W2065856983 @default.
- W3129103650 cites W2066303528 @default.
- W3129103650 cites W2067809581 @default.
- W3129103650 cites W2069934712 @default.
- W3129103650 cites W2070722632 @default.
- W3129103650 cites W2078807175 @default.
- W3129103650 cites W2079753110 @default.
- W3129103650 cites W2079848782 @default.
- W3129103650 cites W2082991622 @default.
- W3129103650 cites W2084292135 @default.
- W3129103650 cites W2088576422 @default.
- W3129103650 cites W2091937552 @default.
- W3129103650 cites W2100204228 @default.
- W3129103650 cites W2112861297 @default.
- W3129103650 cites W2113743226 @default.
- W3129103650 cites W2115115364 @default.
- W3129103650 cites W2117834225 @default.
- W3129103650 cites W2127577115 @default.
- W3129103650 cites W2128473487 @default.
- W3129103650 cites W2132327194 @default.
- W3129103650 cites W2146605832 @default.
- W3129103650 cites W2147576297 @default.
- W3129103650 cites W2153342491 @default.
- W3129103650 cites W2154222514 @default.
- W3129103650 cites W2160238191 @default.
- W3129103650 cites W2160760600 @default.
- W3129103650 cites W2162659138 @default.
- W3129103650 cites W2163388218 @default.
- W3129103650 cites W2166431807 @default.
- W3129103650 cites W2169825101 @default.
- W3129103650 cites W2180953514 @default.
- W3129103650 cites W2229105716 @default.
- W3129103650 cites W2288675614 @default.
- W3129103650 cites W2295625872 @default.
- W3129103650 cites W2300682604 @default.
- W3129103650 cites W2319970884 @default.
- W3129103650 cites W2324841714 @default.
- W3129103650 cites W2333343699 @default.
- W3129103650 cites W2333787143 @default.
- W3129103650 cites W2342051168 @default.
- W3129103650 cites W2415662028 @default.
- W3129103650 cites W2489787941 @default.
- W3129103650 cites W2508221593 @default.
- W3129103650 cites W2520950502 @default.
- W3129103650 cites W2598717691 @default.
- W3129103650 cites W2611482396 @default.
- W3129103650 cites W2766096359 @default.
- W3129103650 cites W2791182539 @default.
- W3129103650 cites W2888696610 @default.
- W3129103650 cites W2903669414 @default.
- W3129103650 cites W2951654213 @default.
- W3129103650 cites W2964046152 @default.
- W3129103650 cites W2967712308 @default.
- W3129103650 cites W3005822303 @default.
- W3129103650 cites W3014799800 @default.
- W3129103650 cites W4294830572 @default.
- W3129103650 doi "https://doi.org/10.1016/j.sleep.2021.01.032" @default.
- W3129103650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33592435" @default.
- W3129103650 hasPublicationYear "2021" @default.
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