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- W3129121642 endingPage "372" @default.
- W3129121642 startingPage "372" @default.
- W3129121642 abstract "Clostridioides difficile is the leading cause of antibiotic-associated diarrhea but can also result in more serious, life-threatening conditions. The incidence of C. difficile infections in hospitals is increasing, both in frequency and severity, and antibiotic-resistant C. difficile strains are advancing. Against this background antimicrobial peptides (AMPs) are an interesting alternative to classic antibiotics. Information on the effects of AMPs on C. difficile will not only enhance the knowledge for possible biomedical application but may also provide insights into mechanisms of C. difficile to adapt or counteract AMPs. This study applies state-of-the-art mass spectrometry methods to quantitatively investigate the proteomic response of C. difficile 630∆erm to sublethal concentrations of the AMP nisin allowing to follow the cellular stress adaptation in a time-resolved manner. The results do not only point at a heavy reorganization of the cellular envelope but also resulted in pronounced changes in central cellular processes such as carbohydrate metabolism. Further, the number of flagella per cell was increased during the adaptation process. The potential involvement of flagella in nisin adaptation was supported by a more resistant phenotype exhibited by a non-motile but hyper-flagellated mutant." @default.
- W3129121642 created "2021-02-15" @default.
- W3129121642 creator A5017371778 @default.
- W3129121642 creator A5017541593 @default.
- W3129121642 creator A5020535728 @default.
- W3129121642 creator A5041989563 @default.
- W3129121642 creator A5047108729 @default.
- W3129121642 creator A5047320723 @default.
- W3129121642 creator A5064294733 @default.
- W3129121642 creator A5077256764 @default.
- W3129121642 date "2021-02-11" @default.
- W3129121642 modified "2023-10-11" @default.
- W3129121642 title "Proteomic Adaptation of Clostridioides difficile to Treatment with the Antimicrobial Peptide Nisin" @default.
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- W3129121642 doi "https://doi.org/10.3390/cells10020372" @default.