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- W3129124430 abstract "Apoptosis, a form of the programmed cell death, is an indispensable defense mechanism regulating cellular homeostasis and is triggered by multiple stimuli. Because of the regulation of apoptosis in cellular homeostasis, viral proteins with apoptotic activity are particular foci of on antitumor therapy. One representative viral protein is the open reading frame 3 (ORF3) protein, also named as apoptin in the Circoviridae chicken anemia virus (CAV), and has the ability to induce tumor-specific apoptosis. Proteins encoded by ORF3 in other circovirus species, such as porcine circovirus (PCV) and duck circovirus (DuCV), have also been reported to induce apoptosis, with subtle differences in apoptotic activity based on cell types. This article is aimed at reviewing the latest research advancements in understanding ORF3 protein-mediated apoptosis mechanisms of Circoviridae from three perspectives: subcellular localization, interactions with host proteins, and participation in multiple apoptotic signaling pathways, providing a scientific basis for circovirus pathogenesis and a reference on its potential anticancer function." @default.
- W3129124430 created "2021-02-15" @default.
- W3129124430 creator A5000460901 @default.
- W3129124430 creator A5005894428 @default.
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- W3129124430 creator A5064308879 @default.
- W3129124430 creator A5068053507 @default.
- W3129124430 creator A5088124858 @default.
- W3129124430 date "2021-02-02" @default.
- W3129124430 modified "2023-10-16" @default.
- W3129124430 title "Apoptosis Triggered by ORF3 Proteins of the Circoviridae Family" @default.
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