Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129125578> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3129125578 endingPage "AB4" @default.
- W3129125578 startingPage "AB4" @default.
- W3129125578 abstract "Asthma treatment response is ascertained by improvement in ≥1 key asthma outcome (exacerbations/symptom control/lung function). This post hoc analysis of LIBERTY ASTHMA QUEST (NCT02414854) assessed dupilumab effect in patients with uncontrolled, moderate-to-severe asthma using a multicomponent endpoint representing various dimensions of clinical asthma remission. Clinical asthma remission components (no exacerbations/5-item Asthma Control Questionnaire [ACQ-5] total score <1.5/post-bronchodilator FEV1 ≥80%) were assessed at Week (Wk)24/Wk52 in 348 dupilumab-treated patients (200/300mg every 2 weeks combined) and 195 matched placebo-treated patients with baseline post-bronchodilator FEV1 <80%, FeNO ≥25ppb, and eosinophils ≥150/μL. Higher percentages of dupilumab-treated patients were exacerbation-free vs placebo (Wk24: 83.3% vs 61.0%; Wk52: 72.7% vs 46.2%). Likewise, more dupilumab-treated patients were exacerbation-free with an ACQ-5 score <1.5 vs placebo (Wk24: 57.5% vs 27.2%; Wk52: 43.1% vs 21.5%). Also, at Wk24, 103 (29.6%) dupilumab-treated patients vs 15 (7.7%) placebo-treated patients were exacerbation-free, with ACQ-5 score <1.5, and post-bronchodilator FEV1 ≥80%, thereby achieving clinical remission; at Wk52, there were 70 (20.1%) vs 9 (4.6%) patients, respectively. Among patients not achieving clinical remission, dupilumab- vs placebo-treated patients still had fewer exacerbations (adjusted annualized rate of severe exacerbations at Wk24/Wk52: 0.63/0.56 vs 1.51/1.46) and improved lung function and asthma control (LS mean change at Wk24/Wk52: 0.20/0.22L vs 0.02/0.03L [FEV1] and −1.33/−1.51 vs −1.00/−1.11 [ACQ-5 score]). Dupilumab treatment could enable patients with uncontrolled moderate-to-severe asthma to achieve a stringent and novel multicomponent endpoint representing clinical asthma remission. Dupilumab substantially reduced exacerbations and improved lung function and asthma control in patients who did not achieve clinical remission." @default.
- W3129125578 created "2021-02-15" @default.
- W3129125578 creator A5017155583 @default.
- W3129125578 creator A5017711682 @default.
- W3129125578 creator A5024338340 @default.
- W3129125578 creator A5033765434 @default.
- W3129125578 creator A5040758734 @default.
- W3129125578 creator A5044544424 @default.
- W3129125578 creator A5044980958 @default.
- W3129125578 creator A5046059982 @default.
- W3129125578 creator A5050993312 @default.
- W3129125578 creator A5055135931 @default.
- W3129125578 creator A5059328493 @default.
- W3129125578 creator A5072622243 @default.
- W3129125578 creator A5078489750 @default.
- W3129125578 creator A5087631945 @default.
- W3129125578 creator A5089685782 @default.
- W3129125578 date "2021-02-01" @default.
- W3129125578 modified "2023-09-27" @default.
- W3129125578 title "Dupilumab Treatment Leads to Clinical Asthma Remission in Patients With Uncontrolled Moderate-to-Severe Asthma With Type 2 Inflammation" @default.
- W3129125578 doi "https://doi.org/10.1016/j.jaci.2020.12.061" @default.
- W3129125578 hasPublicationYear "2021" @default.
- W3129125578 type Work @default.
- W3129125578 sameAs 3129125578 @default.
- W3129125578 citedByCount "5" @default.
- W3129125578 countsByYear W31291255782022 @default.
- W3129125578 countsByYear W31291255782023 @default.
- W3129125578 crossrefType "journal-article" @default.
- W3129125578 hasAuthorship W3129125578A5017155583 @default.
- W3129125578 hasAuthorship W3129125578A5017711682 @default.
- W3129125578 hasAuthorship W3129125578A5024338340 @default.
- W3129125578 hasAuthorship W3129125578A5033765434 @default.
- W3129125578 hasAuthorship W3129125578A5040758734 @default.
- W3129125578 hasAuthorship W3129125578A5044544424 @default.
- W3129125578 hasAuthorship W3129125578A5044980958 @default.
- W3129125578 hasAuthorship W3129125578A5046059982 @default.
- W3129125578 hasAuthorship W3129125578A5050993312 @default.
- W3129125578 hasAuthorship W3129125578A5055135931 @default.
- W3129125578 hasAuthorship W3129125578A5059328493 @default.
- W3129125578 hasAuthorship W3129125578A5072622243 @default.
- W3129125578 hasAuthorship W3129125578A5078489750 @default.
- W3129125578 hasAuthorship W3129125578A5087631945 @default.
- W3129125578 hasAuthorship W3129125578A5089685782 @default.
- W3129125578 hasBestOaLocation W31291255781 @default.
- W3129125578 hasConcept C126322002 @default.
- W3129125578 hasConcept C142724271 @default.
- W3129125578 hasConcept C203092338 @default.
- W3129125578 hasConcept C204787440 @default.
- W3129125578 hasConcept C27081682 @default.
- W3129125578 hasConcept C2776042228 @default.
- W3129125578 hasConcept C2777014857 @default.
- W3129125578 hasConcept C2779824493 @default.
- W3129125578 hasConcept C2781018748 @default.
- W3129125578 hasConcept C535046627 @default.
- W3129125578 hasConcept C71924100 @default.
- W3129125578 hasConcept C90924648 @default.
- W3129125578 hasConceptScore W3129125578C126322002 @default.
- W3129125578 hasConceptScore W3129125578C142724271 @default.
- W3129125578 hasConceptScore W3129125578C203092338 @default.
- W3129125578 hasConceptScore W3129125578C204787440 @default.
- W3129125578 hasConceptScore W3129125578C27081682 @default.
- W3129125578 hasConceptScore W3129125578C2776042228 @default.
- W3129125578 hasConceptScore W3129125578C2777014857 @default.
- W3129125578 hasConceptScore W3129125578C2779824493 @default.
- W3129125578 hasConceptScore W3129125578C2781018748 @default.
- W3129125578 hasConceptScore W3129125578C535046627 @default.
- W3129125578 hasConceptScore W3129125578C71924100 @default.
- W3129125578 hasConceptScore W3129125578C90924648 @default.
- W3129125578 hasIssue "2" @default.
- W3129125578 hasLocation W31291255781 @default.
- W3129125578 hasOpenAccess W3129125578 @default.
- W3129125578 hasPrimaryLocation W31291255781 @default.
- W3129125578 hasRelatedWork W2058375604 @default.
- W3129125578 hasRelatedWork W2109586110 @default.
- W3129125578 hasRelatedWork W2146830701 @default.
- W3129125578 hasRelatedWork W2399290487 @default.
- W3129125578 hasRelatedWork W2435058342 @default.
- W3129125578 hasRelatedWork W2766363313 @default.
- W3129125578 hasRelatedWork W2944657847 @default.
- W3129125578 hasRelatedWork W4291309958 @default.
- W3129125578 hasRelatedWork W4312280085 @default.
- W3129125578 hasRelatedWork W4367604517 @default.
- W3129125578 hasVolume "147" @default.
- W3129125578 isParatext "false" @default.
- W3129125578 isRetracted "false" @default.
- W3129125578 magId "3129125578" @default.
- W3129125578 workType "article" @default.