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• W3129126032 abstract "Neonatal sepsis (NS) remains a global problem. In the present study, abnormal expression of microRNA‑1184 (miR‑1184) was detected in neonates with NS and it was endeavored to investigate the diagnostic value of miR‑1184, as well as its regulatory role in lipopolysaccharide (LPS)‑induced inflammatory response <em>in vitro</em>. Furthermore, the correlation between interleukin‑16 (IL‑16) and miR‑1184 was investigated to elucidate the pathological mechanisms of NS development. Reverse transcription‑quantitative PCR was used to detect the expression of miR‑1184. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic value of miR‑1184 in NS. Furthermore, a sepsis cell model was established by using LPS‑induced monocytes to explore the effect of miR‑1184 on the inflammatory response. The levels of inflammatory cytokines were determined by ELISA. A luciferase reporter assay was used to investigate the direct targeting interaction between miR‑1184 and IL‑16. The results indicated that the serum levels of miR‑1184 in neonates with sepsis were decreased and miR‑1184 had a high diagnostic value when differentiating NS from respiratory conditions in neonates. <em>In vitro</em>, the expression of miR‑1184 in monocytes was inhibited by LPS and overexpression of miR‑1184 reversed the effect of LPS to stimulate the inflammatory response. IL‑16 was demonstrated to be a target of miR‑1184 and a negative correlation between them was identified in patients with NS. The inflammatory response inhibited by miR‑1184 mimics was enhanced by overexpression of IL‑16 in LPS‑induced monocytes. In conclusion, decreased levels of serum miR‑1184 may be a potential diagnostic biomarker for NS. In addition, miR‑1184 inhibited the LPS‑induced inflammatory response by targeting IL‑16 in monocytes, suggesting that the miR‑1184/IL‑16 axis may be a potential therapeutic target for NS." @default.
• W3129126032 created "2021-02-15" @default.
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• W3129126032 date "2021-02-11" @default.
• W3129126032 modified "2023-10-01" @default.
• W3129126032 title "Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes" @default.
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• W3129126032 doi "https://doi.org/10.3892/etm.2021.9781" @default.
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