Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129156959> ?p ?o ?g. }
- W3129156959 endingPage "235" @default.
- W3129156959 startingPage "235" @default.
- W3129156959 abstract "NUT carcinoma (NC) is a type of aggressive cancer driven by chromosome translocations. Fusion genes between a DNA-binding protein, such as bromodomain and extraterminal domain (BET) proteins, and the testis-specific protein NUTM1 generated by these translocations drive the formation of NC. NC can develop in very young children without significant accumulation of somatic mutations, presenting a relatively clean model to study the genetic etiology of oncogenesis. However, after 20 years of research, a few challenging questions still remain for understanding the mechanism and developing therapeutics for NC. In this short review, we first briefly summarize the current knowledge regarding the molecular mechanism and targeted therapy development of NC. We then raise three challenging questions: (1) What is the cell of origin of NC? (2) How does the germline analogous epigenetic reprogramming process driven by the BET-NUTM1 fusion proteins cause NC? and (3) How will BET-NUTM1 targeted therapies be developed? We propose that with the unprecedented technological advancements in genome editing, animal models, stem cell biology, organoids, and chemical biology, we have unique opportunities to address these challenges." @default.
- W3129156959 created "2021-02-15" @default.
- W3129156959 creator A5000915602 @default.
- W3129156959 creator A5052554325 @default.
- W3129156959 date "2021-02-05" @default.
- W3129156959 modified "2023-10-03" @default.
- W3129156959 title "Challenges and Opportunities in NUT Carcinoma Research" @default.
- W3129156959 cites W1565539350 @default.
- W3129156959 cites W1625510017 @default.
- W3129156959 cites W1642405165 @default.
- W3129156959 cites W1911253268 @default.
- W3129156959 cites W1965813899 @default.
- W3129156959 cites W1968238001 @default.
- W3129156959 cites W1971821333 @default.
- W3129156959 cites W1984236721 @default.
- W3129156959 cites W1988075836 @default.
- W3129156959 cites W1994939279 @default.
- W3129156959 cites W1998469647 @default.
- W3129156959 cites W2003491273 @default.
- W3129156959 cites W2007527830 @default.
- W3129156959 cites W2010243546 @default.
- W3129156959 cites W2018253132 @default.
- W3129156959 cites W2028959752 @default.
- W3129156959 cites W2029572722 @default.
- W3129156959 cites W2041535798 @default.
- W3129156959 cites W2052692973 @default.
- W3129156959 cites W2069695937 @default.
- W3129156959 cites W2110721869 @default.
- W3129156959 cites W2111901894 @default.
- W3129156959 cites W2125828985 @default.
- W3129156959 cites W2130970481 @default.
- W3129156959 cites W2132682917 @default.
- W3129156959 cites W2134549313 @default.
- W3129156959 cites W2139066576 @default.
- W3129156959 cites W2139414608 @default.
- W3129156959 cites W2140754284 @default.
- W3129156959 cites W2141040794 @default.
- W3129156959 cites W2143163999 @default.
- W3129156959 cites W2150406181 @default.
- W3129156959 cites W2156862506 @default.
- W3129156959 cites W2158125144 @default.
- W3129156959 cites W2164727752 @default.
- W3129156959 cites W2169074308 @default.
- W3129156959 cites W2169944837 @default.
- W3129156959 cites W2171595327 @default.
- W3129156959 cites W2298793032 @default.
- W3129156959 cites W2403475582 @default.
- W3129156959 cites W2508500919 @default.
- W3129156959 cites W2566521622 @default.
- W3129156959 cites W2588319976 @default.
- W3129156959 cites W2592060299 @default.
- W3129156959 cites W2612477391 @default.
- W3129156959 cites W2614850398 @default.
- W3129156959 cites W2620562886 @default.
- W3129156959 cites W2622762717 @default.
- W3129156959 cites W2733066269 @default.
- W3129156959 cites W2779743226 @default.
- W3129156959 cites W2792453707 @default.
- W3129156959 cites W2800081119 @default.
- W3129156959 cites W2800664103 @default.
- W3129156959 cites W2807624799 @default.
- W3129156959 cites W2808584871 @default.
- W3129156959 cites W2890016264 @default.
- W3129156959 cites W2892893971 @default.
- W3129156959 cites W2898168488 @default.
- W3129156959 cites W2947039670 @default.
- W3129156959 cites W2953837653 @default.
- W3129156959 cites W2955742145 @default.
- W3129156959 cites W2969279439 @default.
- W3129156959 cites W2971252234 @default.
- W3129156959 cites W2973445191 @default.
- W3129156959 cites W2979601486 @default.
- W3129156959 cites W3000673710 @default.
- W3129156959 cites W3008709031 @default.
- W3129156959 cites W3016213906 @default.
- W3129156959 cites W3022175316 @default.
- W3129156959 cites W3040646360 @default.
- W3129156959 cites W3087130263 @default.
- W3129156959 cites W3102624934 @default.
- W3129156959 cites W3125377737 @default.
- W3129156959 doi "https://doi.org/10.3390/genes12020235" @default.
- W3129156959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7915910" @default.
- W3129156959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33562801" @default.
- W3129156959 hasPublicationYear "2021" @default.
- W3129156959 type Work @default.
- W3129156959 sameAs 3129156959 @default.
- W3129156959 citedByCount "5" @default.
- W3129156959 countsByYear W31291569592021 @default.
- W3129156959 countsByYear W31291569592022 @default.
- W3129156959 countsByYear W31291569592023 @default.
- W3129156959 crossrefType "journal-article" @default.
- W3129156959 hasAuthorship W3129156959A5000915602 @default.
- W3129156959 hasAuthorship W3129156959A5052554325 @default.
- W3129156959 hasBestOaLocation W31291569591 @default.
- W3129156959 hasConcept C104317684 @default.
- W3129156959 hasConcept C109825262 @default.
- W3129156959 hasConcept C111472728 @default.
- W3129156959 hasConcept C121608353 @default.