FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129161791> ?p ?o ?g. }

• W3129161791 abstract "Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): The Norwegian Health Association Background Left bundle branch block (LBBB) worsen prognosis in heart failure patients. LBBB may also cause heart failure in otherwise healthy individuals. The mechanical changes induced by LBBB are potential determinants of heart failure in these patients, but their relation to left ventricular (LV) systolic function is incompletely understood. Purpose This study investigates the contribution of regional contractile function to heart failure in patients with LBBB. Methods In 76 patients with LBBB and 11 healthy controls, myocardial strain was measured by speckle-tracking echocardiography and myocardial work by pressure-strain analysis. Patients with ischemic heart disease or myocardial scarring were excluded. LBBB patients were stratified by LV ejection fraction (EF) &gt;50% (EFpreserved), 36-50% (EFmid), and ≤35% (EFlow). 62 LBBB patients subsequently underwent cardiac resynchronization therapy (CRT) implantation and was re-examined at 6 months. Results Septal work was significantly and successively reduced from controls, EFpreserved, EFmid, to EFlow (1977 ± 506, 1025 ± 342, 601 ± 494 and -41 ± 303 mmHg·%, respectively, all p &lt; 0.01) (Figure 1). There was a strong correlation (R = 0.84, p &lt; 0.01) between septal work and LVEF. In contrast, work in the LV lateral wall was preserved in both EFpreserved (2367 ± 459 mmHg·%) and EFmid (2252 ± 449 mmHg·%) vs controls (2062 ± 459 mmHg·%, all NS). In the EFlow group, however, LV lateral wall work was reduced (1473 ± 568 mmHg·%, p &lt; 0.01 vs controls). Thus, lateral wall function was not correlated with LVEF in patients with LVEF &gt;35% (NS). At six month CRT septal work was markedly increased (165 ± 485 vs 1288 ± 523 mmHg·%, p &lt; 0.01) and LV lateral wall work reduced (1730 ± 620 vs 1264 ± 490 mmHg·%, p &lt; 0.01). LVEF increased from 32 ± 8 to 47 ± 10 % (p &lt; 0.01). Conclusions Heart failure in LBBB patients is determined by degree of septal dysfunction. LV lateral wall function, on the other hand, is preserved in the early phase of heart failure and was only reduced in patients with severe heart failure. Further clinical studies should investigate if measuring LV lateral wall function can increase precision in patient selection for CRT. Abstract Figure." @default.
• W3129161791 created "2021-02-15" @default.
• W3129161791 creator A5004194402 @default.
• W3129161791 creator A5008480160 @default.
• W3129161791 creator A5009564964 @default.
• W3129161791 creator A5012990553 @default.
• W3129161791 creator A5023102117 @default.
• W3129161791 creator A5043290587 @default.
• W3129161791 creator A5044479141 @default.
• W3129161791 creator A5053229052 @default.
• W3129161791 creator A5058372949 @default.
• W3129161791 creator A5059029738 @default.
• W3129161791 creator A5065154872 @default.
• W3129161791 creator A5071593474 @default.
• W3129161791 creator A5078067317 @default.
• W3129161791 creator A5078814774 @default.
• W3129161791 date "2021-01-01" @default.
• W3129161791 modified "2023-09-27" @default.
• W3129161791 title "Regional myocardial work as determinant of heart failure in left bundle branch block" @default.
• W3129161791 doi "https://doi.org/10.1093/ehjci/jeaa356.031" @default.
• W3129161791 hasPublicationYear "2021" @default.
• W3129161791 type Work @default.
• W3129161791 sameAs 3129161791 @default.
• W3129161791 citedByCount "0" @default.
• W3129161791 crossrefType "journal-article" @default.
• W3129161791 hasAuthorship W3129161791A5004194402 @default.
• W3129161791 hasAuthorship W3129161791A5008480160 @default.
• W3129161791 hasAuthorship W3129161791A5009564964 @default.
• W3129161791 hasAuthorship W3129161791A5012990553 @default.
• W3129161791 hasAuthorship W3129161791A5023102117 @default.
• W3129161791 hasAuthorship W3129161791A5043290587 @default.
• W3129161791 hasAuthorship W3129161791A5044479141 @default.
• W3129161791 hasAuthorship W3129161791A5053229052 @default.
• W3129161791 hasAuthorship W3129161791A5058372949 @default.
• W3129161791 hasAuthorship W3129161791A5059029738 @default.
• W3129161791 hasAuthorship W3129161791A5065154872 @default.
• W3129161791 hasAuthorship W3129161791A5071593474 @default.
• W3129161791 hasAuthorship W3129161791A5078067317 @default.
• W3129161791 hasAuthorship W3129161791A5078814774 @default.
• W3129161791 hasBestOaLocation W31291617911 @default.
• W3129161791 hasConcept C126322002 @default.
• W3129161791 hasConcept C164705383 @default.
• W3129161791 hasConcept C2776034619 @default.
• W3129161791 hasConcept C2777233412 @default.
• W3129161791 hasConcept C2777473070 @default.
• W3129161791 hasConcept C2778198053 @default.
• W3129161791 hasConcept C2778296771 @default.
• W3129161791 hasConcept C2780040984 @default.
• W3129161791 hasConcept C71924100 @default.
• W3129161791 hasConcept C78085059 @default.
• W3129161791 hasConceptScore W3129161791C126322002 @default.
• W3129161791 hasConceptScore W3129161791C164705383 @default.
• W3129161791 hasConceptScore W3129161791C2776034619 @default.
• W3129161791 hasConceptScore W3129161791C2777233412 @default.
• W3129161791 hasConceptScore W3129161791C2777473070 @default.
• W3129161791 hasConceptScore W3129161791C2778198053 @default.
• W3129161791 hasConceptScore W3129161791C2778296771 @default.
• W3129161791 hasConceptScore W3129161791C2780040984 @default.
• W3129161791 hasConceptScore W3129161791C71924100 @default.
• W3129161791 hasConceptScore W3129161791C78085059 @default.
• W3129161791 hasLocation W31291617911 @default.
• W3129161791 hasOpenAccess W3129161791 @default.
• W3129161791 hasPrimaryLocation W31291617911 @default.
• W3129161791 hasRelatedWork W11689764 @default.
• W3129161791 hasRelatedWork W11839477 @default.
• W3129161791 hasRelatedWork W1369280 @default.
• W3129161791 hasRelatedWork W16045677 @default.
• W3129161791 hasRelatedWork W16563608 @default.
• W3129161791 hasRelatedWork W3093987 @default.
• W3129161791 hasRelatedWork W5184897 @default.
• W3129161791 hasRelatedWork W9868683 @default.
• W3129161791 hasRelatedWork W9873483 @default.
• W3129161791 hasRelatedWork W6646289 @default.
• W3129161791 isParatext "false" @default.
• W3129161791 isRetracted "false" @default.
• W3129161791 magId "3129161791" @default.
• W3129161791 workType "article" @default.