FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129164101> ?p ?o ?g. }

• W3129164101 endingPage "2815" @default.
• W3129164101 startingPage "2806" @default.
• W3129164101 abstract "Abstract We have previously shown that adenine monophosphate‐activated protein kinase (AMPK) regulates transforming growth factor β (TGF‐β)‐triggered Smad3 phosphorylation. Here we report that AMPK inhibits TGF‐β1 production. First, metformin reduced mRNA levels of TGF‐β1 in gastric cancer cells, in parallel to the decrease of its protein abundance. The effects were more prominent in the cells containing LKB1, an upstream kinase of AMPK. Second, knockdown of Smad3 by siRNA abrogated the expression of TGF‐β1. Third, metformin suppressed firefly luciferase activity whose transcription was driven by TGF‐β1 promoter. In accordance, deletion of the putative binding site of Smad3 in the TGF‐β1 promoter region severely impaired the promoter activity and response to metformin. Fourth, in support of our in vitro study, clinical treatment of type 2 diabetes with metformin significantly reduced the plasma level of TGF‐β1. Finally, immunohistochemical studies revealed that TGF‐β1 was highly expressed in human gastric cancer tissues as compared with adjacent normal tissues. In contrast, p‐AMPK exhibited opposite changes. Furthermore, the survival rate of gastric cancer patients was positively correlated with p‐AMPK and negative with TGF‐β1. Therefore, our present studies depict a mechanism underlying AMPK suppression of TGF‐β1 autoinduction, which is mediated through inhibition of Smad3 phosphorylation and activation. Collectively, our study sheds a light on the potential usage of AMPK activators in the treatment of TGF‐β1‐mediated gastric cancer progression." @default.
• W3129164101 created "2021-02-15" @default.
• W3129164101 creator A5009590736 @default.
• W3129164101 creator A5018801130 @default.
• W3129164101 creator A5019271797 @default.
• W3129164101 creator A5054556302 @default.
• W3129164101 creator A5055735453 @default.
• W3129164101 creator A5061222638 @default.
• W3129164101 creator A5081805949 @default.
• W3129164101 date "2021-02-03" @default.
• W3129164101 modified "2023-10-15" @default.
• W3129164101 title "AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells" @default.
• W3129164101 cites W1483064409 @default.
• W3129164101 cites W1604062873 @default.
• W3129164101 cites W1980957356 @default.
• W3129164101 cites W2023947368 @default.
• W3129164101 cites W2036791863 @default.
• W3129164101 cites W2066665398 @default.
• W3129164101 cites W2070214100 @default.
• W3129164101 cites W2075497099 @default.
• W3129164101 cites W2080612545 @default.
• W3129164101 cites W2087614953 @default.
• W3129164101 cites W2093531115 @default.
• W3129164101 cites W2122568309 @default.
• W3129164101 cites W2136280424 @default.
• W3129164101 cites W2141574380 @default.
• W3129164101 cites W2155598285 @default.
• W3129164101 cites W2178859203 @default.
• W3129164101 cites W2195370592 @default.
• W3129164101 cites W2201828897 @default.
• W3129164101 cites W2243864136 @default.
• W3129164101 cites W2276308812 @default.
• W3129164101 cites W2317113145 @default.
• W3129164101 cites W2589857327 @default.
• W3129164101 cites W2592339836 @default.
• W3129164101 cites W2594729995 @default.
• W3129164101 cites W2737735431 @default.
• W3129164101 cites W2765192645 @default.
• W3129164101 cites W2782546429 @default.
• W3129164101 cites W2807063223 @default.
• W3129164101 cites W2923587505 @default.
• W3129164101 cites W2937823726 @default.
• W3129164101 cites W2953793510 @default.
• W3129164101 doi "https://doi.org/10.1111/jcmm.16308" @default.
• W3129164101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7957200" @default.
• W3129164101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33538080" @default.
• W3129164101 hasPublicationYear "2021" @default.
• W3129164101 type Work @default.
• W3129164101 sameAs 3129164101 @default.
• W3129164101 citedByCount "10" @default.
• W3129164101 countsByYear W31291641012021 @default.
• W3129164101 countsByYear W31291641012022 @default.
• W3129164101 countsByYear W31291641012023 @default.
• W3129164101 crossrefType "journal-article" @default.
• W3129164101 hasAuthorship W3129164101A5009590736 @default.
• W3129164101 hasAuthorship W3129164101A5018801130 @default.
• W3129164101 hasAuthorship W3129164101A5019271797 @default.
• W3129164101 hasAuthorship W3129164101A5054556302 @default.
• W3129164101 hasAuthorship W3129164101A5055735453 @default.
• W3129164101 hasAuthorship W3129164101A5061222638 @default.
• W3129164101 hasAuthorship W3129164101A5081805949 @default.
• W3129164101 hasBestOaLocation W31291641011 @default.
• W3129164101 hasConcept C118131993 @default.
• W3129164101 hasConcept C11960822 @default.
• W3129164101 hasConcept C121608353 @default.
• W3129164101 hasConcept C126322002 @default.
• W3129164101 hasConcept C134018914 @default.
• W3129164101 hasConcept C173396325 @default.
• W3129164101 hasConcept C184235292 @default.
• W3129164101 hasConcept C185592680 @default.
• W3129164101 hasConcept C190283241 @default.
• W3129164101 hasConcept C2776780712 @default.
• W3129164101 hasConcept C2778229498 @default.
• W3129164101 hasConcept C2780124434 @default.
• W3129164101 hasConcept C2780323712 @default.
• W3129164101 hasConcept C502942594 @default.
• W3129164101 hasConcept C55493867 @default.
• W3129164101 hasConcept C555293320 @default.
• W3129164101 hasConcept C71924100 @default.
• W3129164101 hasConcept C86803240 @default.
• W3129164101 hasConcept C95444343 @default.
• W3129164101 hasConcept C96232424 @default.
• W3129164101 hasConcept C97029542 @default.
• W3129164101 hasConceptScore W3129164101C118131993 @default.
• W3129164101 hasConceptScore W3129164101C11960822 @default.
• W3129164101 hasConceptScore W3129164101C121608353 @default.
• W3129164101 hasConceptScore W3129164101C126322002 @default.
• W3129164101 hasConceptScore W3129164101C134018914 @default.
• W3129164101 hasConceptScore W3129164101C173396325 @default.
• W3129164101 hasConceptScore W3129164101C184235292 @default.
• W3129164101 hasConceptScore W3129164101C185592680 @default.
• W3129164101 hasConceptScore W3129164101C190283241 @default.
• W3129164101 hasConceptScore W3129164101C2776780712 @default.
• W3129164101 hasConceptScore W3129164101C2778229498 @default.
• W3129164101 hasConceptScore W3129164101C2780124434 @default.
• W3129164101 hasConceptScore W3129164101C2780323712 @default.
• W3129164101 hasConceptScore W3129164101C502942594 @default.
• W3129164101 hasConceptScore W3129164101C55493867 @default.

• next