FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129226391> ?p ?o ?g. }

• W3129226391 abstract "ABSTRACT Activation of the stimulator of interferon genes (STING) pathway through cyclic dinucleotides (CDNs) has been explored extensively as potent vaccine adjuvants against infectious diseases as well as to increase tumor immunogenicity towards cancer immunotherapy in solid tumors. Over the last decade, a myriad of synthetic vehicles, including liposomes, polymers, and other nanoparticle platforms, have been developed to improve the bioavailability and therapeutic efficacy of STING agonists in preclinical mouse models. In comparison to synthetic materials, protein-based carriers represent an attractive delivery platform owing to their biocompatibility, amenability to genetic engineering, and intrinsic capacity to form well-defined structures. In the present work, we have engineered the immune adaptor STING as a protein-based delivery system for efficient encapsulation and intracellular delivery of CDNs. Through genetic fusion with a protein transduction domain, the recombinant STING can spontaneously penetrate cells to markedly enhance the delivery of CDNs in a mouse vaccination model and a syngeneic mouse melanoma model. Moreover, motivated by recent findings that certain tumor cells can evade immune surveillance via loss of STING expression, we further unveiled that our STING platform can serve as a functional vehicle to restore the STING signaling in a panel of lung and melanoma cell lines with impaired STING expression. Taken together, our STING-based protein delivery platform may offer a unique direction towards targeting STING-silenced tumors as well as augmenting the efficacy of STING-based vaccine adjuvants." @default.
• W3129226391 created "2021-03-01" @default.
• W3129226391 creator A5000012249 @default.
• W3129226391 creator A5029630247 @default.
• W3129226391 creator A5057597665 @default.
• W3129226391 creator A5060353514 @default.
• W3129226391 creator A5079905678 @default.
• W3129226391 creator A5081518337 @default.
• W3129226391 creator A5088345060 @default.
• W3129226391 creator A5089734920 @default.
• W3129226391 date "2021-02-18" @default.
• W3129226391 modified "2023-09-27" @default.
• W3129226391 title "Engineering the Immune Adaptor Protein STING as a Biologic" @default.
• W3129226391 cites W1898887656 @default.
• W3129226391 cites W1993860509 @default.
• W3129226391 cites W2066818317 @default.
• W3129226391 cites W2081796577 @default.
• W3129226391 cites W2145190710 @default.
• W3129226391 cites W2169908694 @default.
• W3129226391 cites W2220279767 @default.
• W3129226391 cites W2237797200 @default.
• W3129226391 cites W2409411217 @default.
• W3129226391 cites W2525369565 @default.
• W3129226391 cites W2536322725 @default.
• W3129226391 cites W2586653152 @default.
• W3129226391 cites W2604145804 @default.
• W3129226391 cites W2753490666 @default.
• W3129226391 cites W2768756688 @default.
• W3129226391 cites W2794137041 @default.
• W3129226391 cites W2795875233 @default.
• W3129226391 cites W2895058922 @default.
• W3129226391 cites W2900220188 @default.
• W3129226391 cites W2907665228 @default.
• W3129226391 cites W2909554490 @default.
• W3129226391 cites W2919704769 @default.
• W3129226391 cites W2919896467 @default.
• W3129226391 cites W2924424204 @default.
• W3129226391 cites W2927684362 @default.
• W3129226391 cites W2942052760 @default.
• W3129226391 cites W2945775408 @default.
• W3129226391 cites W2950889989 @default.
• W3129226391 cites W2959930806 @default.
• W3129226391 cites W2970843395 @default.
• W3129226391 cites W2982455170 @default.
• W3129226391 cites W2995171541 @default.
• W3129226391 cites W3007626908 @default.
• W3129226391 cites W3011282656 @default.
• W3129226391 cites W3012408003 @default.
• W3129226391 cites W3034580303 @default.
• W3129226391 cites W3043278305 @default.
• W3129226391 cites W3044974503 @default.
• W3129226391 cites W3047822613 @default.
• W3129226391 cites W3048895526 @default.
• W3129226391 cites W3120903220 @default.
• W3129226391 doi "https://doi.org/10.1101/2021.02.18.431824" @default.
• W3129226391 hasPublicationYear "2021" @default.
• W3129226391 type Work @default.
• W3129226391 sameAs 3129226391 @default.
• W3129226391 citedByCount "1" @default.
• W3129226391 countsByYear W31292263912021 @default.
• W3129226391 crossrefType "posted-content" @default.
• W3129226391 hasAuthorship W3129226391A5000012249 @default.
• W3129226391 hasAuthorship W3129226391A5029630247 @default.
• W3129226391 hasAuthorship W3129226391A5057597665 @default.
• W3129226391 hasAuthorship W3129226391A5060353514 @default.
• W3129226391 hasAuthorship W3129226391A5079905678 @default.
• W3129226391 hasAuthorship W3129226391A5081518337 @default.
• W3129226391 hasAuthorship W3129226391A5088345060 @default.
• W3129226391 hasAuthorship W3129226391A5089734920 @default.
• W3129226391 hasBestOaLocation W31292263911 @default.
• W3129226391 hasConcept C127413603 @default.
• W3129226391 hasConcept C136449434 @default.
• W3129226391 hasConcept C146978453 @default.
• W3129226391 hasConcept C183786373 @default.
• W3129226391 hasConcept C203014093 @default.
• W3129226391 hasConcept C2777349159 @default.
• W3129226391 hasConcept C2777701055 @default.
• W3129226391 hasConcept C2779300339 @default.
• W3129226391 hasConcept C2780674031 @default.
• W3129226391 hasConcept C2780868878 @default.
• W3129226391 hasConcept C502942594 @default.
• W3129226391 hasConcept C62478195 @default.
• W3129226391 hasConcept C71924100 @default.
• W3129226391 hasConcept C86803240 @default.
• W3129226391 hasConcept C8891405 @default.
• W3129226391 hasConcept C95444343 @default.
• W3129226391 hasConceptScore W3129226391C127413603 @default.
• W3129226391 hasConceptScore W3129226391C136449434 @default.
• W3129226391 hasConceptScore W3129226391C146978453 @default.
• W3129226391 hasConceptScore W3129226391C183786373 @default.
• W3129226391 hasConceptScore W3129226391C203014093 @default.
• W3129226391 hasConceptScore W3129226391C2777349159 @default.
• W3129226391 hasConceptScore W3129226391C2777701055 @default.
• W3129226391 hasConceptScore W3129226391C2779300339 @default.
• W3129226391 hasConceptScore W3129226391C2780674031 @default.
• W3129226391 hasConceptScore W3129226391C2780868878 @default.
• W3129226391 hasConceptScore W3129226391C502942594 @default.
• W3129226391 hasConceptScore W3129226391C62478195 @default.
• W3129226391 hasConceptScore W3129226391C71924100 @default.
• W3129226391 hasConceptScore W3129226391C86803240 @default.

• next