Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129249930> ?p ?o ?g. }
- W3129249930 abstract "Abstract Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses ubiquitous features of mammalian genomes. However, millions of years of evolution obscure many of the immediate repercussions of retroviral endogenisation on host health. Here we examine retroviral endogenisation during its earliest stages in the koala ( Phascolarctos cinereus ), a species undergoing germline invasion by koala retrovirus (KoRV) and affected by high cancer prevalence. We characterise KoRV integration sites (IS) in tumour and healthy tissues from 10 koalas, detecting 1002 unique IS, with hotspots of integration occurring in the vicinity of known cancer genes. We find that tumours accumulate novel IS, with proximate genes over-represented for cancer associations. We detect dysregulation of genes containing IS and identify a highly-expressed transduced oncogene. Our data provide insights into the tremendous mutational load suffered by the host during active retroviral germline invasion, a process repeatedly experienced and overcome during the evolution of vertebrate lineages." @default.
- W3129249930 created "2021-03-01" @default.
- W3129249930 creator A5000997916 @default.
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- W3129249930 creator A5091320190 @default.
- W3129249930 date "2021-02-26" @default.
- W3129249930 modified "2023-10-01" @default.
- W3129249930 title "Retroviral integrations contribute to elevated host cancer rates during germline invasion" @default.
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