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- W3129326761 abstract "Diverse processes in healthcare, agriculture, and the environment rely on bacterial motility in porous media; indeed, most bacterial habitats—e.g. biological gels, tissues, soils, and sediments—are heterogeneous porous media. However, while bacterial motility is well-studied in homogeneous environments, how confinement in a porous environment impacts bacterial transport remains poorly understood. To address this gap in knowledge, we combine microscopy, materials fabrication, and microbiology to investigate how E. coli moves in 3D porous media. by probing single cells, we demonstrate that the paradigm of run-and-tumble motility is dramatically altered by pore-scale confinement. instead, we find a new mode of motility in which cells are intermittently and transiently trapped as they navigate the pore space; analysis of these dynamics enables prediction of bacterial transport over large length and time scales. Further, by developing a new 3D printing approach, we design multi-cellular communities with precise control over the spatial distribution of bacteria. Using this approach, we show that concentrated populations can collectively migrate through a porous medium—despite being strongly confined—and that pore-scale confinement is a strong regulator of chemotactic migration. Strikingly, cells use a different primary mechanism to direct their motion in confinement than in bulk liquid. Further, confinement markedly alters the dynamics and morphology of the migrating population—features that can be described by a continuum model, but only when standard motility parameters are substantially altered from their bulk liquid values. Our work thus provides a framework to predict and control the migration of bacteria, and active matter in general, in heterogeneous environments." @default.
- W3129326761 created "2021-03-01" @default.
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- W3129326761 date "2021-02-01" @default.
- W3129326761 modified "2023-09-28" @default.
- W3129326761 title "Life in a Tight Spot: Motility of Bacteria in Heterogeneous Environments" @default.
- W3129326761 doi "https://doi.org/10.1016/j.bpj.2020.11.641" @default.
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