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• W3129330404 abstract "The prognostic impact of the different tumor-infiltrating lymphocyte (TIL) subpopulations in solid cancers is still debated. Here, we investigated the clinicopathological correlates and prognostic impact of TILs, particularly of γδ T cells, in 162 patients with triple-negative breast cancer (TNBC). A high γδ T cell density (>6.625 γδ T cells/mm2) was associated with younger age (p = 0.008), higher tumor histological grade (p = 0.002), adjuvant chemotherapy (p = 0.010), BRCA1 promoter methylation (p = 0.010), TIL density (p < 0.001), and PD-L1 (p < 0.001) and PD-1 expression (p = 0.040). In multivariate analyses, γδ T cell infiltration (cutoff = 6.625 γδ T cells/mm2) was an independent prognostic factor (5-year relapse-free survival: 63.3% vs. 89.8%, p = 0.027; 5-year overall survival: 73.8% vs. 89.9%, p = 0.031, for low vs. high infiltration). This prognostic impact varied according to the tumor PIK3CA mutational status. High γδ T cell infiltration was associated with better survival in patients with PIK3CA wild-type tumors, but the difference was not significant in the subgroup with PIK3CA-mutated tumors. Altogether, these data suggest that high γδ T cell infiltrate is correlated with immune infiltration and might represent a candidate prognostic tool in patients with TNBC." @default.
• W3129330404 created "2021-03-01" @default.
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• W3129330404 date "2021-02-12" @default.
• W3129330404 modified "2023-10-18" @default.
• W3129330404 title "Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer" @default.
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• W3129330404 doi "https://doi.org/10.3390/cancers13040765" @default.
• W3129330404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7918092" @default.
• W3129330404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33673133" @default.
• W3129330404 hasPublicationYear "2021" @default.
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