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- W3129331244 endingPage "131" @default.
- W3129331244 startingPage "124" @default.
- W3129331244 abstract "•Capnography can be used adjuvantly to diagnose ketotic states such as ketogenic diet (KD) and diabetic ketoacidosis (DKA). •This study evaluates the usage of end-tidal carbon dioxide (EtCO2) in nutritional ketosis such as short term KD. •Our finding shows that short term KD does not exert changes in the EtCO2. Background & aims Previous studies have shown that end-tidal carbon dioxide (EtCO2) is lower with the presence of supraphysiological ketones as in the case of chronic ketogenic diet (KD) and diabetic ketoacidosis (DKA). This study aimed to determine changes in EtCO2 upon short term KD. Methods Healthy subjects were screened not to have conditions that exerts abnormal EtCO2 nor contraindicated for KD. Subjects underwent seven days of KD while the EtCO2 and blood ketone (beta-hydroxybutyrate; β-OHB) parameters were sampled at day zero (t0) and seven (t7) of ketosis respectively. Statistically, the t-test and Pearson's coefficient were conducted to determine the changes and correlation of both parameters. Results 12 subjects completed the study. The mean score ± standard deviation (SD) for EtCO2 were 35.08 ± 3.53 and 35.67 ± 3.31 mm Hg for t0 and t7 respectively. The mean score ±SD for β-OHB were 0.07 ± 0.08 and 0.87 ± 0.84 mmol/L for t0 and t7 respectively. There was no significant difference of EtCO2 between the period of study (p > 0.05) but the β-OHB increased during t7 (p < 0.05). There was also no correlation between the parameters. Conclusions These findings suggest that EtCO2 may not be utilized to determine short term nutritional ketosis. Previous studies have shown that end-tidal carbon dioxide (EtCO2) is lower with the presence of supraphysiological ketones as in the case of chronic ketogenic diet (KD) and diabetic ketoacidosis (DKA). This study aimed to determine changes in EtCO2 upon short term KD. Healthy subjects were screened not to have conditions that exerts abnormal EtCO2 nor contraindicated for KD. Subjects underwent seven days of KD while the EtCO2 and blood ketone (beta-hydroxybutyrate; β-OHB) parameters were sampled at day zero (t0) and seven (t7) of ketosis respectively. Statistically, the t-test and Pearson's coefficient were conducted to determine the changes and correlation of both parameters. 12 subjects completed the study. The mean score ± standard deviation (SD) for EtCO2 were 35.08 ± 3.53 and 35.67 ± 3.31 mm Hg for t0 and t7 respectively. The mean score ±SD for β-OHB were 0.07 ± 0.08 and 0.87 ± 0.84 mmol/L for t0 and t7 respectively. There was no significant difference of EtCO2 between the period of study (p > 0.05) but the β-OHB increased during t7 (p < 0.05). There was also no correlation between the parameters. These findings suggest that EtCO2 may not be utilized to determine short term nutritional ketosis." @default.
- W3129331244 created "2021-03-01" @default.
- W3129331244 creator A5007990458 @default.
- W3129331244 creator A5011803849 @default.
- W3129331244 creator A5044165008 @default.
- W3129331244 creator A5076418171 @default.
- W3129331244 creator A5083151864 @default.
- W3129331244 date "2021-04-01" @default.
- W3129331244 modified "2023-10-16" @default.
- W3129331244 title "Effect of short-term ketogenic diet on end-tidal carbon dioxide" @default.
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