FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129332489> ?p ?o ?g. }

• W3129332489 endingPage "161" @default.
• W3129332489 startingPage "161" @default.
• W3129332489 abstract "Microsporidiosis is an emerging opportunistic infection causing severe digestive disorders in immunocompromised patients. The aim of this study was to investigate the prevalence of intestinal microsporidia carriage among immunocompromised patients hospitalized at a major hospital complex in the Tunis capital area, Tunisia (North Africa), and perform molecular epidemiology and population structure analyses of Enterocytozoon bieneusi, which is an emerging fungal pathogen. We screened 250 stool samples for the presence of intestinal microsporidia from 171 patients, including 81 organ transplant recipients, 73 Human Immunodeficiency Virus (HIV)-positive patients, and 17 patients with unspecified immunodeficiency. Using a nested PCR-based diagnostic approach for the detection of E. bieneusi and Encephalitozoon spp., we identified 18 microsporidia-positive patients out of 171 (10.5%), among which 17 were infected with E. bieneusi. Microsporidia-positive cases displayed chronic diarrhea (17 out of 18), which was associated more with HIV rather than with immunosuppression other than HIV (12 out of 73 versus 6 out of 98, respectively, p = 0.02) and correlated with extended hospital stays compared to microsporidia-negative cases (60 versus 19 days on average, respectively; p = 0.001). Strikingly, internal transcribed spacer (ITS)-based genotyping of E. bieneusi strains revealed high-frequency occurrence of ITS sequences that were identical (n = 10) or similar (with one single polymorphic site, n = 3) to rare genotype WL12. Minimum-spanning tree analyses segregated the 17 E. bieneusi infection cases into four distinct genotypic clusters and confirmed the high prevalence of genotype WL12 in our patient population. Phylogenetic analyses allowed the mapping of all 17 E. bieneusi strains to zoonotic group 1 (subgroups 1a and 1b/1c), indicating loose host specificity and raising public health concern. Our study suggests a probable common source of E. bieneusi genotype WL12 transmission and prompts the implementation of a wider epidemiological investigation." @default.
• W3129332489 created "2021-03-01" @default.
• W3129332489 creator A5000768231 @default.
• W3129332489 creator A5008714163 @default.
• W3129332489 creator A5009665281 @default.
• W3129332489 creator A5013581985 @default.
• W3129332489 creator A5016692869 @default.
• W3129332489 creator A5022864459 @default.
• W3129332489 creator A5024522698 @default.
• W3129332489 creator A5029847499 @default.
• W3129332489 creator A5031501653 @default.
• W3129332489 creator A5061177533 @default.
• W3129332489 creator A5069584964 @default.
• W3129332489 creator A5070099949 @default.
• W3129332489 creator A5070120031 @default.
• W3129332489 creator A5079103670 @default.
• W3129332489 date "2021-02-24" @default.
• W3129332489 modified "2023-09-27" @default.
• W3129332489 title "High Frequency of Enterocytozoon bieneusi Genotype WL12 Occurrence among Immunocompromised Patients with Intestinal Microsporidiosis" @default.
• W3129332489 cites W1964161836 @default.
• W3129332489 cites W1968062495 @default.
• W3129332489 cites W1971506800 @default.
• W3129332489 cites W1975554659 @default.
• W3129332489 cites W1981767171 @default.
• W3129332489 cites W1981980855 @default.
• W3129332489 cites W1983479194 @default.
• W3129332489 cites W1997391434 @default.
• W3129332489 cites W1997655790 @default.
• W3129332489 cites W1999739695 @default.
• W3129332489 cites W2002905609 @default.
• W3129332489 cites W2019409308 @default.
• W3129332489 cites W2034362020 @default.
• W3129332489 cites W2038553755 @default.
• W3129332489 cites W2043623938 @default.
• W3129332489 cites W2043990330 @default.
• W3129332489 cites W2048815616 @default.
• W3129332489 cites W2052446744 @default.
• W3129332489 cites W2059180912 @default.
• W3129332489 cites W2066275867 @default.
• W3129332489 cites W2069285053 @default.
• W3129332489 cites W2075373193 @default.
• W3129332489 cites W2085737527 @default.
• W3129332489 cites W2089816273 @default.
• W3129332489 cites W2094738712 @default.
• W3129332489 cites W2097105412 @default.
• W3129332489 cites W2100436431 @default.
• W3129332489 cites W2101048789 @default.
• W3129332489 cites W2101092476 @default.
• W3129332489 cites W2101717861 @default.
• W3129332489 cites W2105104067 @default.
• W3129332489 cites W2107942562 @default.
• W3129332489 cites W2141596764 @default.
• W3129332489 cites W2153545740 @default.
• W3129332489 cites W2154655701 @default.
• W3129332489 cites W2160291142 @default.
• W3129332489 cites W2167201288 @default.
• W3129332489 cites W2170286853 @default.
• W3129332489 cites W2263652181 @default.
• W3129332489 cites W2277860485 @default.
• W3129332489 cites W2605612089 @default.
• W3129332489 cites W2756492088 @default.
• W3129332489 cites W2772482478 @default.
• W3129332489 cites W2783891790 @default.
• W3129332489 cites W2793674588 @default.
• W3129332489 cites W2793715089 @default.
• W3129332489 cites W2805320617 @default.
• W3129332489 cites W2884915151 @default.
• W3129332489 cites W2897108380 @default.
• W3129332489 cites W2898533646 @default.
• W3129332489 cites W2899403585 @default.
• W3129332489 cites W2943908926 @default.
• W3129332489 cites W2966176486 @default.
• W3129332489 cites W2972204224 @default.
• W3129332489 cites W2979691427 @default.
• W3129332489 cites W3007762993 @default.
• W3129332489 cites W3037049398 @default.
• W3129332489 cites W3127984282 @default.
• W3129332489 cites W4243432706 @default.
• W3129332489 cites W4249091668 @default.
• W3129332489 doi "https://doi.org/10.3390/jof7030161" @default.
• W3129332489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7996336" @default.
• W3129332489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33668221" @default.
• W3129332489 hasPublicationYear "2021" @default.
• W3129332489 type Work @default.
• W3129332489 sameAs 3129332489 @default.
• W3129332489 citedByCount "3" @default.
• W3129332489 countsByYear W31293324892022 @default.
• W3129332489 countsByYear W31293324892023 @default.
• W3129332489 crossrefType "journal-article" @default.
• W3129332489 hasAuthorship W3129332489A5000768231 @default.
• W3129332489 hasAuthorship W3129332489A5008714163 @default.
• W3129332489 hasAuthorship W3129332489A5009665281 @default.
• W3129332489 hasAuthorship W3129332489A5013581985 @default.
• W3129332489 hasAuthorship W3129332489A5016692869 @default.
• W3129332489 hasAuthorship W3129332489A5022864459 @default.
• W3129332489 hasAuthorship W3129332489A5024522698 @default.
• W3129332489 hasAuthorship W3129332489A5029847499 @default.
• W3129332489 hasAuthorship W3129332489A5031501653 @default.

• next