FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129335952> ?p ?o ?g. }

• W3129335952 abstract "Abstract Environmental factors contribute to the risk for adverse health outcomes against a background of genetic predisposition. Among these factors, chemical exposures may substantially contribute to disease risk and adverse outcomes. In fact, epidemiological cohort studies have established associations between exposure against individual chemicals and adverse health effects. Yet, in daily life individuals are exposed to complex mixtures in varying compositions. To capture the totality of environmental exposures the concept of the exposome has been developed. Here, we undertake an overview of major exposome projects, which pioneered the field of exposomics and explored the links between chemical exposure and health outcomes using cohort studies. We seek to reflect their achievements with regard to (i) capturing a comprehensive picture of the environmental chemical exposome, (ii) aggregating internal exposures using chemical and bioanalytical means of detection, and (iii) identifying associations that provide novel options for risk assessment and intervention. Various complementary approaches can be distinguished in addressing relevant exposure routes and it emerges that individual exposure histories may not easily be grouped. The number of chemicals for which human exposure can be detected is substantial and highlights the reality of mixture exposures. Yet, to a large extent it depends on targeted chemical analysis with the specific challenges to capture all relevant exposure routes and assess the chemical concentrations occurring in humans. The currently used approaches imply prior knowledge or hypotheses about relevant exposures. Typically, the number of chemicals considered in exposome projects is counted in dozens—in contrast to the several thousands of chemicals for which occurrence have been reported in human serum and urine. Furthermore, health outcomes are often still compared to single chemicals only. Moreover, explicit consideration of mixture effects and the interrelations between different outcomes to support causal relationships and identify risk drivers in complex mixtures remain underdeveloped and call for specifically designed exposome-cohort studies." @default.
• W3129335952 created "2021-03-01" @default.
• W3129335952 creator A5010034789 @default.
• W3129335952 creator A5019740923 @default.
• W3129335952 creator A5039007417 @default.
• W3129335952 creator A5052859681 @default.
• W3129335952 creator A5062953653 @default.
• W3129335952 creator A5090835142 @default.
• W3129335952 date "2021-02-11" @default.
• W3129335952 modified "2023-09-25" @default.
• W3129335952 title "Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive" @default.
• W3129335952 cites W1561483904 @default.
• W3129335952 cites W1585343692 @default.
• W3129335952 cites W1965830185 @default.
• W3129335952 cites W1966533725 @default.
• W3129335952 cites W1993957210 @default.
• W3129335952 cites W1994742756 @default.
• W3129335952 cites W1998623345 @default.
• W3129335952 cites W2007241324 @default.
• W3129335952 cites W2017229541 @default.
• W3129335952 cites W2023195783 @default.
• W3129335952 cites W2046818404 @default.
• W3129335952 cites W2053369230 @default.
• W3129335952 cites W2053606298 @default.
• W3129335952 cites W2059184965 @default.
• W3129335952 cites W2060365113 @default.
• W3129335952 cites W2060871509 @default.
• W3129335952 cites W2075878847 @default.
• W3129335952 cites W2083451194 @default.
• W3129335952 cites W2085425659 @default.
• W3129335952 cites W2095646018 @default.
• W3129335952 cites W2101274375 @default.
• W3129335952 cites W2102562142 @default.
• W3129335952 cites W2104284672 @default.
• W3129335952 cites W2104443195 @default.
• W3129335952 cites W2107552147 @default.
• W3129335952 cites W2110052313 @default.
• W3129335952 cites W2110272025 @default.
• W3129335952 cites W2117972978 @default.
• W3129335952 cites W2126344159 @default.
• W3129335952 cites W2134742846 @default.
• W3129335952 cites W2137167968 @default.
• W3129335952 cites W2138649409 @default.
• W3129335952 cites W2140008210 @default.
• W3129335952 cites W2142930729 @default.
• W3129335952 cites W2143509157 @default.
• W3129335952 cites W2145072286 @default.
• W3129335952 cites W2162878065 @default.
• W3129335952 cites W2276480169 @default.
• W3129335952 cites W2315838341 @default.
• W3129335952 cites W2331408036 @default.
• W3129335952 cites W2468100412 @default.
• W3129335952 cites W2504855122 @default.
• W3129335952 cites W2511776817 @default.
• W3129335952 cites W2512767308 @default.
• W3129335952 cites W2514945659 @default.
• W3129335952 cites W2520673416 @default.
• W3129335952 cites W2526047447 @default.
• W3129335952 cites W2529176515 @default.
• W3129335952 cites W2532406567 @default.
• W3129335952 cites W2533446135 @default.
• W3129335952 cites W2560714335 @default.
• W3129335952 cites W2574723869 @default.
• W3129335952 cites W2587451412 @default.
• W3129335952 cites W2605174521 @default.
• W3129335952 cites W2606677796 @default.
• W3129335952 cites W2735301192 @default.
• W3129335952 cites W2735609371 @default.
• W3129335952 cites W2737960303 @default.
• W3129335952 cites W2765726697 @default.
• W3129335952 cites W2767683865 @default.
• W3129335952 cites W2767772291 @default.
• W3129335952 cites W2772476494 @default.
• W3129335952 cites W2786833611 @default.
• W3129335952 cites W2789806379 @default.
• W3129335952 cites W2794924826 @default.
• W3129335952 cites W2796266696 @default.
• W3129335952 cites W2808614222 @default.
• W3129335952 cites W2889052904 @default.
• W3129335952 cites W2890718782 @default.
• W3129335952 cites W2891201019 @default.
• W3129335952 cites W2896403590 @default.
• W3129335952 cites W2896996768 @default.
• W3129335952 cites W2904291994 @default.
• W3129335952 cites W2906699453 @default.
• W3129335952 cites W2914438210 @default.
• W3129335952 cites W2914749726 @default.
• W3129335952 cites W2914955705 @default.
• W3129335952 cites W2922155412 @default.
• W3129335952 cites W2936683995 @default.
• W3129335952 cites W2941416238 @default.
• W3129335952 cites W2947730791 @default.
• W3129335952 cites W2949338713 @default.
• W3129335952 cites W2971737841 @default.
• W3129335952 cites W2975219453 @default.
• W3129335952 cites W2984957779 @default.
• W3129335952 cites W2986767149 @default.
• W3129335952 cites W2995593899 @default.
• W3129335952 cites W3009661489 @default.
• W3129335952 cites W3011085354 @default.

• next