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- W3129339917 abstract "Genome-wide association studies (GWAS) have been used to study the genetic basis of a wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for three molecular traits-urate, IGF-1, and testosterone-with better-understood biology than most other complex traits. We find that many of the most significant hits are readily interpretable. We observe huge enrichment of associations near genes involved in the relevant biosynthesis, transport, or signaling pathways. We show how GWAS data illuminate the biology of each trait, including differences in testosterone regulation between females and males. At the same time, even these molecular traits are highly polygenic, with many thousands of variants spread across the genome contributing to trait variance. In summary, for these three molecular traits we identify strong enrichment of signal in putative core gene sets, even while most of the SNP-based heritability is driven by a massively polygenic background." @default.
- W3129339917 created "2021-03-01" @default.
- W3129339917 creator A5002455648 @default.
- W3129339917 creator A5035872488 @default.
- W3129339917 creator A5051388103 @default.
- W3129339917 creator A5073710029 @default.
- W3129339917 date "2021-02-15" @default.
- W3129339917 modified "2023-10-17" @default.
- W3129339917 title "GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background" @default.
- W3129339917 cites W1513376696 @default.
- W3129339917 cites W1581079125 @default.
- W3129339917 cites W1844405070 @default.
- W3129339917 cites W1967690795 @default.
- W3129339917 cites W1968213466 @default.
- W3129339917 cites W1968295028 @default.
- W3129339917 cites W1971299565 @default.
- W3129339917 cites W1971857747 @default.
- W3129339917 cites W1976811955 @default.
- W3129339917 cites W1980991473 @default.
- W3129339917 cites W1985066712 @default.
- W3129339917 cites W1987493079 @default.
- W3129339917 cites W1989308141 @default.
- W3129339917 cites W1996048503 @default.
- W3129339917 cites W1996652934 @default.
- W3129339917 cites W1998957301 @default.
- W3129339917 cites W2008047653 @default.
- W3129339917 cites W2012476152 @default.
- W3129339917 cites W2012505775 @default.
- W3129339917 cites W2015450625 @default.
- W3129339917 cites W2017219759 @default.
- W3129339917 cites W2031999522 @default.
- W3129339917 cites W2042103448 @default.
- W3129339917 cites W2042256117 @default.
- W3129339917 cites W2044444556 @default.
- W3129339917 cites W2051314902 @default.
- W3129339917 cites W2061478312 @default.
- W3129339917 cites W2067130406 @default.
- W3129339917 cites W2076002484 @default.
- W3129339917 cites W2076924133 @default.
- W3129339917 cites W2078638321 @default.
- W3129339917 cites W2086307866 @default.
- W3129339917 cites W2091087465 @default.
- W3129339917 cites W2091398724 @default.
- W3129339917 cites W2093369971 @default.
- W3129339917 cites W2095240081 @default.
- W3129339917 cites W2098247759 @default.
- W3129339917 cites W2098597355 @default.
- W3129339917 cites W2099659064 @default.
- W3129339917 cites W2101164395 @default.
- W3129339917 cites W2101357408 @default.
- W3129339917 cites W2105902511 @default.
- W3129339917 cites W2108434880 @default.
- W3129339917 cites W2111241216 @default.
- W3129339917 cites W2113213861 @default.
- W3129339917 cites W2122729366 @default.
- W3129339917 cites W2133647910 @default.
- W3129339917 cites W2134471459 @default.
- W3129339917 cites W2139852278 @default.
- W3129339917 cites W2141292631 @default.
- W3129339917 cites W2146738944 @default.
- W3129339917 cites W2147452548 @default.
- W3129339917 cites W2148075385 @default.
- W3129339917 cites W2149843002 @default.
- W3129339917 cites W2150866339 @default.
- W3129339917 cites W2153312936 @default.
- W3129339917 cites W2153359028 @default.
- W3129339917 cites W2153860431 @default.
- W3129339917 cites W2154131855 @default.
- W3129339917 cites W2155225646 @default.
- W3129339917 cites W2155496693 @default.
- W3129339917 cites W2159460045 @default.
- W3129339917 cites W2162426271 @default.
- W3129339917 cites W2163118201 @default.
- W3129339917 cites W2166122846 @default.
- W3129339917 cites W2168354474 @default.
- W3129339917 cites W2171816696 @default.
- W3129339917 cites W2255138985 @default.
- W3129339917 cites W2257508508 @default.
- W3129339917 cites W2280070832 @default.
- W3129339917 cites W2329391383 @default.
- W3129339917 cites W2401811918 @default.
- W3129339917 cites W2411763125 @default.
- W3129339917 cites W2461170015 @default.
- W3129339917 cites W2469213152 @default.
- W3129339917 cites W2559250903 @default.
- W3129339917 cites W2571503386 @default.
- W3129339917 cites W2623657421 @default.
- W3129339917 cites W2626606138 @default.
- W3129339917 cites W2735155748 @default.
- W3129339917 cites W2764310005 @default.
- W3129339917 cites W2765089908 @default.
- W3129339917 cites W2767038995 @default.
- W3129339917 cites W2768151250 @default.
- W3129339917 cites W2782069931 @default.
- W3129339917 cites W2790653691 @default.
- W3129339917 cites W2790718366 @default.
- W3129339917 cites W2791118826 @default.
- W3129339917 cites W2796811655 @default.
- W3129339917 cites W2801710305 @default.
- W3129339917 cites W2802411153 @default.