Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129343053> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3129343053 abstract "Abstract Compared to linear mixed model-based genome-wide association (GWA) methods, generalized linear mixed model (GLMM)-based methods have better statistical properties when applied to binary traits but are computationally much slower. Here, leveraging efficient sparse matrix-based algorithms, we developed a GLMM-based GWA tool (called fastGWA-GLMM) that is orders of magnitude faster than the state-of-the-art tool (e.g., ~37 times faster when n=400,000) with more scalable memory usage. We show by simulation that the fastGWA-GLMM test-statistics of both common and rare variants are well-calibrated under the null, even for traits with an extreme case-control ratio (e.g., 0.1%). We applied fastGWA-GLMM to the UK Biobank data of 456,348 individuals, 11,842,647 variants and 2,989 binary traits (full summary statistics available at http://fastgwa.info/ukbimpbin) and identified 259 rare variants associated with 75 traits, demonstrating the use of imputed genotype data in a large cohort to discover rare variants for binary complex traits." @default.
- W3129343053 created "2021-03-01" @default.
- W3129343053 creator A5002628620 @default.
- W3129343053 creator A5054249391 @default.
- W3129343053 creator A5065532777 @default.
- W3129343053 date "2021-02-12" @default.
- W3129343053 modified "2023-10-17" @default.
- W3129343053 title "FastGWA-GLMM: a generalized linear mixed model association tool for biobank-scale data" @default.
- W3129343053 cites W1966775465 @default.
- W3129343053 cites W1966825973 @default.
- W3129343053 cites W2018309757 @default.
- W3129343053 cites W2065975091 @default.
- W3129343053 cites W2099085143 @default.
- W3129343053 cites W2127684760 @default.
- W3129343053 cites W2141916112 @default.
- W3129343053 cites W2178232667 @default.
- W3129343053 cites W2511515754 @default.
- W3129343053 cites W2798750837 @default.
- W3129343053 cites W2895486342 @default.
- W3129343053 cites W2991212521 @default.
- W3129343053 doi "https://doi.org/10.21203/rs.3.rs-128758/v1" @default.
- W3129343053 hasPublicationYear "2021" @default.
- W3129343053 type Work @default.
- W3129343053 sameAs 3129343053 @default.
- W3129343053 citedByCount "2" @default.
- W3129343053 countsByYear W31293430532021 @default.
- W3129343053 countsByYear W31293430532023 @default.
- W3129343053 crossrefType "posted-content" @default.
- W3129343053 hasAuthorship W3129343053A5002628620 @default.
- W3129343053 hasAuthorship W3129343053A5054249391 @default.
- W3129343053 hasAuthorship W3129343053A5065532777 @default.
- W3129343053 hasBestOaLocation W31293430531 @default.
- W3129343053 hasConcept C104317684 @default.
- W3129343053 hasConcept C105795698 @default.
- W3129343053 hasConcept C106208931 @default.
- W3129343053 hasConcept C116567970 @default.
- W3129343053 hasConcept C135763542 @default.
- W3129343053 hasConcept C153209595 @default.
- W3129343053 hasConcept C153720581 @default.
- W3129343053 hasConcept C16012445 @default.
- W3129343053 hasConcept C33923547 @default.
- W3129343053 hasConcept C41008148 @default.
- W3129343053 hasConcept C41587187 @default.
- W3129343053 hasConcept C54355233 @default.
- W3129343053 hasConcept C86803240 @default.
- W3129343053 hasConceptScore W3129343053C104317684 @default.
- W3129343053 hasConceptScore W3129343053C105795698 @default.
- W3129343053 hasConceptScore W3129343053C106208931 @default.
- W3129343053 hasConceptScore W3129343053C116567970 @default.
- W3129343053 hasConceptScore W3129343053C135763542 @default.
- W3129343053 hasConceptScore W3129343053C153209595 @default.
- W3129343053 hasConceptScore W3129343053C153720581 @default.
- W3129343053 hasConceptScore W3129343053C16012445 @default.
- W3129343053 hasConceptScore W3129343053C33923547 @default.
- W3129343053 hasConceptScore W3129343053C41008148 @default.
- W3129343053 hasConceptScore W3129343053C41587187 @default.
- W3129343053 hasConceptScore W3129343053C54355233 @default.
- W3129343053 hasConceptScore W3129343053C86803240 @default.
- W3129343053 hasLocation W31293430531 @default.
- W3129343053 hasOpenAccess W3129343053 @default.
- W3129343053 hasPrimaryLocation W31293430531 @default.
- W3129343053 hasRelatedWork W1992914993 @default.
- W3129343053 hasRelatedWork W2015581436 @default.
- W3129343053 hasRelatedWork W2033200554 @default.
- W3129343053 hasRelatedWork W2052460524 @default.
- W3129343053 hasRelatedWork W2141245559 @default.
- W3129343053 hasRelatedWork W2773648299 @default.
- W3129343053 hasRelatedWork W2991212521 @default.
- W3129343053 hasRelatedWork W3129343053 @default.
- W3129343053 hasRelatedWork W3210382439 @default.
- W3129343053 hasRelatedWork W4376617003 @default.
- W3129343053 isParatext "false" @default.
- W3129343053 isRetracted "false" @default.
- W3129343053 magId "3129343053" @default.
- W3129343053 workType "article" @default.