FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129397769> ?p ?o ?g. }

• W3129397769 endingPage "1946" @default.
• W3129397769 startingPage "1946" @default.
• W3129397769 abstract "Chorioamnionitis, an important cause of preterm birth, is linked to necrotizing enterocolitis (NEC). NEC is characterized by a disrupted mucus barrier, goblet cell loss, and endoplasmic reticulum (ER) stress of the intestinal epithelium. These findings prompted us to investigate the mechanisms underlying goblet cell alterations over time in an ovine chorioamnionitis model. Fetal lambs were intra-amniotically (IA) exposed to lipopolysaccharides (LPS) for 5, 12, or 24 h, or 2, 4, 8, or 15 d before premature delivery at 125 d gestational age (GA). Gut inflammation, the number, distribution, and differentiation of goblet cells, ER stress, and apoptosis were measured. We found a biphasic reduction in goblet cell numbers 24 h–2 d after, and 15 d after IA LPS exposure. The second decrease of goblet cell numbers was preceded by intestinal inflammation, apoptosis, and crypt ER stress, and increased SAM-pointed domain-containing ETS transcription factor (SPDEF)-positive cell counts. Our combined findings indicated that ER stress drives apoptosis of maturating goblet cells during chorioamnionitis, ultimately reducing goblet cell numbers. As similar changes have been described in patients suffering from NEC, these findings are considered to be clinically important for understanding the predecessors of NEC, and targeting ER stress in this context is interesting for future therapeutics." @default.
• W3129397769 created "2021-03-01" @default.
• W3129397769 creator A5001053552 @default.
• W3129397769 creator A5005981389 @default.
• W3129397769 creator A5015589373 @default.
• W3129397769 creator A5019576860 @default.
• W3129397769 creator A5036645819 @default.
• W3129397769 creator A5041654270 @default.
• W3129397769 creator A5042277620 @default.
• W3129397769 creator A5048997124 @default.
• W3129397769 creator A5050844526 @default.
• W3129397769 creator A5051377327 @default.
• W3129397769 creator A5052301147 @default.
• W3129397769 creator A5059284202 @default.
• W3129397769 creator A5069942321 @default.
• W3129397769 creator A5070573910 @default.
• W3129397769 date "2021-02-16" @default.
• W3129397769 modified "2023-10-14" @default.
• W3129397769 title "Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications" @default.
• W3129397769 cites W1893553316 @default.
• W3129397769 cites W1927073913 @default.
• W3129397769 cites W1976611079 @default.
• W3129397769 cites W1991781946 @default.
• W3129397769 cites W1997114875 @default.
• W3129397769 cites W2008711121 @default.
• W3129397769 cites W2011337131 @default.
• W3129397769 cites W2015250685 @default.
• W3129397769 cites W2015920478 @default.
• W3129397769 cites W2016087279 @default.
• W3129397769 cites W2031735410 @default.
• W3129397769 cites W2066538173 @default.
• W3129397769 cites W2066826529 @default.
• W3129397769 cites W2067862842 @default.
• W3129397769 cites W2070986849 @default.
• W3129397769 cites W2072226297 @default.
• W3129397769 cites W2072747307 @default.
• W3129397769 cites W2079269415 @default.
• W3129397769 cites W2082732215 @default.
• W3129397769 cites W2082898864 @default.
• W3129397769 cites W2083589469 @default.
• W3129397769 cites W2089198803 @default.
• W3129397769 cites W2093970825 @default.
• W3129397769 cites W2094878840 @default.
• W3129397769 cites W2096579470 @default.
• W3129397769 cites W2099975088 @default.
• W3129397769 cites W2104826177 @default.
• W3129397769 cites W2104956723 @default.
• W3129397769 cites W2120950548 @default.
• W3129397769 cites W2133728642 @default.
• W3129397769 cites W2134575990 @default.
• W3129397769 cites W2141300346 @default.
• W3129397769 cites W2146883005 @default.
• W3129397769 cites W2159155233 @default.
• W3129397769 cites W2160839546 @default.
• W3129397769 cites W2162695817 @default.
• W3129397769 cites W2163899199 @default.
• W3129397769 cites W2167862372 @default.
• W3129397769 cites W2171125452 @default.
• W3129397769 cites W2228523154 @default.
• W3129397769 cites W2289835306 @default.
• W3129397769 cites W2410017695 @default.
• W3129397769 cites W2803793575 @default.
• W3129397769 cites W2897848781 @default.
• W3129397769 cites W2899936624 @default.
• W3129397769 cites W2914924449 @default.
• W3129397769 cites W2940940566 @default.
• W3129397769 cites W2972788513 @default.
• W3129397769 cites W2974767470 @default.
• W3129397769 cites W2986185827 @default.
• W3129397769 cites W3011053040 @default.
• W3129397769 cites W3083025947 @default.
• W3129397769 cites W3083668462 @default.
• W3129397769 cites W4235469056 @default.
• W3129397769 doi "https://doi.org/10.3390/ijms22041946" @default.
• W3129397769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7920290" @default.
• W3129397769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33669331" @default.
• W3129397769 hasPublicationYear "2021" @default.
• W3129397769 type Work @default.
• W3129397769 sameAs 3129397769 @default.
• W3129397769 citedByCount "6" @default.
• W3129397769 countsByYear W31293977692021 @default.
• W3129397769 countsByYear W31293977692022 @default.
• W3129397769 countsByYear W31293977692023 @default.
• W3129397769 crossrefType "journal-article" @default.
• W3129397769 hasAuthorship W3129397769A5001053552 @default.
• W3129397769 hasAuthorship W3129397769A5005981389 @default.
• W3129397769 hasAuthorship W3129397769A5015589373 @default.
• W3129397769 hasAuthorship W3129397769A5019576860 @default.
• W3129397769 hasAuthorship W3129397769A5036645819 @default.
• W3129397769 hasAuthorship W3129397769A5041654270 @default.
• W3129397769 hasAuthorship W3129397769A5042277620 @default.
• W3129397769 hasAuthorship W3129397769A5048997124 @default.
• W3129397769 hasAuthorship W3129397769A5050844526 @default.
• W3129397769 hasAuthorship W3129397769A5051377327 @default.
• W3129397769 hasAuthorship W3129397769A5052301147 @default.
• W3129397769 hasAuthorship W3129397769A5059284202 @default.
• W3129397769 hasAuthorship W3129397769A5069942321 @default.
• W3129397769 hasAuthorship W3129397769A5070573910 @default.

• next