Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129435897> ?p ?o ?g. }
- W3129435897 abstract "Significance CNTF is a leading therapeutic candidate for glaucoma and other ocular diseases and is widely used experimentally to promote axon regeneration after optic nerve injury. Paradoxically, whereas CNTF gene therapy is neuroprotective for retinal ganglion cells and promotes considerable regeneration following optic nerve injury, recombinant CNTF has little effect. We show that CNTF gene therapy exacerbates the inflammatory reaction to virally mediated gene therapy, leading to widespread expression of chemokine CCL5. Blocking CCL5 signaling abrogates most neuroprotective and axon-promoting effects of CNTF gene therapy, whereas recombinant CCL5 largely mimics the beneficial effects of CNTF gene therapy. Thus, this study identifies a potent, previously unknown agent for optic nerve regeneration and raises general questions about interpreting results of gene therapy studies." @default.
- W3129435897 created "2021-03-01" @default.
- W3129435897 creator A5071574564 @default.
- W3129435897 creator A5077781746 @default.
- W3129435897 creator A5089278826 @default.
- W3129435897 date "2021-02-24" @default.
- W3129435897 modified "2023-10-16" @default.
- W3129435897 title "Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy" @default.
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