Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129437299> ?p ?o ?g. }
- W3129437299 abstract "Abstract The drug delivery in vascular lesions is still challenging due to blood flow and complex dynamic physiological environment. Therefore, therapeutic bioadhesives are promising materials in replacement of drug eluting stents because of their unique features such as oriented delivering therapeutic agents, biodegradability, and avoidance of second injury. However, the adhesive strength of bioadhesives is seriously deteriorated in the moist environment of vessel surface. Herein, a rapid and simple method to prepare novel mussel‐inspired drug‐loaded bioadhesive through self‐assembly between lysine and 3,4‐dihydroxyphenylalanine (DPA) functionalized poly(acrylic acid) is reported. The abundant DPA moieties endow adhesive strong underwater adhesion, which can reach the highest adhesion strength of 718 kPa. The adhesive shows 2.9‐fold and 14.7‐fold wet adhesion strength, more than that of the commercial cyanoacrylate and fibrin sealant. Such bioadhesive can serve as an efficient delivery vehicle for controlled‐release of drugs paclitaxel (PTX), which is successfully encapsulated in adhesive showing a durable (>200 h) sustained release. The capability on inhibition of neointima and enhancement of reendothelialization of injured artery are further confirmed in vivo. The novel therapeutic adhesive with injectability, biodegradability, and biocompatibility shows promising potential in the application in vessel therapy." @default.
- W3129437299 created "2021-03-01" @default.
- W3129437299 creator A5009332911 @default.
- W3129437299 creator A5011797086 @default.
- W3129437299 creator A5014180932 @default.
- W3129437299 creator A5017565201 @default.
- W3129437299 creator A5025877682 @default.
- W3129437299 creator A5027398598 @default.
- W3129437299 creator A5027483909 @default.
- W3129437299 creator A5054199825 @default.
- W3129437299 creator A5073607494 @default.
- W3129437299 creator A5073823705 @default.
- W3129437299 date "2021-02-24" @default.
- W3129437299 modified "2023-10-10" @default.
- W3129437299 title "Injectable and Biocompatible Mussel‐Inspired Adhesive for Enhanced Reendothelialization of Injured Artery" @default.
- W3129437299 cites W1189346619 @default.
- W3129437299 cites W1585589485 @default.
- W3129437299 cites W1766761376 @default.
- W3129437299 cites W1767127227 @default.
- W3129437299 cites W1977895956 @default.
- W3129437299 cites W1981771754 @default.
- W3129437299 cites W1989497070 @default.
- W3129437299 cites W1991192406 @default.
- W3129437299 cites W2001137990 @default.
- W3129437299 cites W2005033237 @default.
- W3129437299 cites W2007978511 @default.
- W3129437299 cites W2021324467 @default.
- W3129437299 cites W2024159944 @default.
- W3129437299 cites W2026607816 @default.
- W3129437299 cites W2035332297 @default.
- W3129437299 cites W2063480385 @default.
- W3129437299 cites W2064527547 @default.
- W3129437299 cites W2070079250 @default.
- W3129437299 cites W2074861758 @default.
- W3129437299 cites W2085996722 @default.
- W3129437299 cites W2089231433 @default.
- W3129437299 cites W2095183223 @default.
- W3129437299 cites W2095383348 @default.
- W3129437299 cites W2103500142 @default.
- W3129437299 cites W2103511109 @default.
- W3129437299 cites W2118002605 @default.
- W3129437299 cites W2133422297 @default.
- W3129437299 cites W2144633240 @default.
- W3129437299 cites W2153027939 @default.
- W3129437299 cites W2167979615 @default.
- W3129437299 cites W2205743670 @default.
- W3129437299 cites W2265472564 @default.
- W3129437299 cites W2334327918 @default.
- W3129437299 cites W2464406097 @default.
- W3129437299 cites W2472871404 @default.
- W3129437299 cites W2532209517 @default.
- W3129437299 cites W2574180453 @default.
- W3129437299 cites W2592953811 @default.
- W3129437299 cites W2603504444 @default.
- W3129437299 cites W2606908323 @default.
- W3129437299 cites W2620617519 @default.
- W3129437299 cites W2716286825 @default.
- W3129437299 cites W2726709346 @default.
- W3129437299 cites W2749203848 @default.
- W3129437299 cites W2765194828 @default.
- W3129437299 cites W2785273344 @default.
- W3129437299 cites W2795095181 @default.
- W3129437299 cites W2801913163 @default.
- W3129437299 cites W2805614331 @default.
- W3129437299 cites W2896952147 @default.
- W3129437299 cites W2897475306 @default.
- W3129437299 cites W2925221887 @default.
- W3129437299 cites W2933010889 @default.
- W3129437299 cites W2937787823 @default.
- W3129437299 cites W2940194767 @default.
- W3129437299 cites W814415559 @default.
- W3129437299 doi "https://doi.org/10.1002/admi.202001955" @default.
- W3129437299 hasPublicationYear "2021" @default.
- W3129437299 type Work @default.
- W3129437299 sameAs 3129437299 @default.
- W3129437299 citedByCount "6" @default.
- W3129437299 countsByYear W31294372992021 @default.
- W3129437299 countsByYear W31294372992022 @default.
- W3129437299 countsByYear W31294372992023 @default.
- W3129437299 crossrefType "journal-article" @default.
- W3129437299 hasAuthorship W3129437299A5009332911 @default.
- W3129437299 hasAuthorship W3129437299A5011797086 @default.
- W3129437299 hasAuthorship W3129437299A5014180932 @default.
- W3129437299 hasAuthorship W3129437299A5017565201 @default.
- W3129437299 hasAuthorship W3129437299A5025877682 @default.
- W3129437299 hasAuthorship W3129437299A5027398598 @default.
- W3129437299 hasAuthorship W3129437299A5027483909 @default.
- W3129437299 hasAuthorship W3129437299A5054199825 @default.
- W3129437299 hasAuthorship W3129437299A5073607494 @default.
- W3129437299 hasAuthorship W3129437299A5073823705 @default.
- W3129437299 hasConcept C1318750 @default.
- W3129437299 hasConcept C136229726 @default.
- W3129437299 hasConcept C150903083 @default.
- W3129437299 hasConcept C159985019 @default.
- W3129437299 hasConcept C171250308 @default.
- W3129437299 hasConcept C191897082 @default.
- W3129437299 hasConcept C192562407 @default.
- W3129437299 hasConcept C207001950 @default.
- W3129437299 hasConcept C2776634624 @default.
- W3129437299 hasConcept C2777230088 @default.