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- W3129451338 abstract "Natural products are useful tools for biological mechanism research and drug discovery. Due to the excellent tumor cell growth inhibitory profile and sub-nanomolar potency, Coibamide A (CA), an N-methyl-stabilized depsipeptide isolated from marine cyanobacterium, has been considered as a promising lead compound for cancer treatment. However, the molecular anti-cancer mechanism of the action of CA remains unclear. Here, we showed that CA treatment induced caspase-independent cell death in breast cancer cells. CA treatment also led to severe lysosome defects, which was ascribed to the impaired glycosylation of lysosome membrane protein LAMP1 and LAMP2. As a consequence, the autophagosome-lysosome fusion was blocked upon CA treatment. In addition, we presented evidence that this autophagy defect partially contributed to the CA treatment-induced tumor cell death. Together, our work uncovers a novel mechanism underlying the anti-cancer action of CA, which will promote its further application for cancer therapy." @default.
- W3129451338 created "2021-03-01" @default.
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- W3129451338 date "2021-04-01" @default.
- W3129451338 modified "2023-10-17" @default.
- W3129451338 title "Coibamide A kills cancer cells through inhibiting autophagy" @default.
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- W3129451338 doi "https://doi.org/10.1016/j.bbrc.2021.01.112" @default.
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