FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129459286> ?p ?o ?g. }

• W3129459286 abstract "BACKGROUND:Enzymatically inactive chitinase-like protein CHI3L1 is overexpressed in diffuse large B cell lymphoma (DLBCL) patients with PD-L1 imbalance and promotes tumor progression in the microenvironment. Based on this, we investigated how CHI3L1 acts on the proliferation and apoptosis of DLBCL and whether there is a synergy of CHI3L1 in combination with anti-PD-L1 antibodies in vivo. MATERIAL AND METHODS:CHI3L1 was detected by quantitative real-time PCR (RT-PCR) and western blot (WB) in B-lymphoma cell lines. CHI3L1 interference plasmids were constructed, and the levels of proliferation, cell cycle, apoptosis, and cell survival were examined in vitro in B-lymphoma cell lines and in vivo in a murine xenograft model by RT-PCR, WB, CCK-8, and flow cytometry. RESULTS:CHI3L1 was significantly expressed in SU-DHL-4 cells. CHI3L1-interfered RNA ShRNA-CHI3L1-1 was chosen to be used in the next experiment because it had a better interference effect. Dampened cell proliferation level, arrested cell cycle, reduced protein expressions of cyclin D1 and cyclin D2, and promoted cell apoptosis level were observed after SU-DHL-4 was transfected with ShRNA-CHI3L1-1. Furthermore, we also noticed increased expression of Bcl-2, decreased expressions of bax, cleaved caspase 3 and cleaved PARP, promoted cell survival-related protein p53, and reduced survivin. CONCLUSIONS:This study demonstrated that knockdown of CHI3L1 inhibits cancer cell proliferation by regulating cell cycles, promotes cancer cell apoptosis, and enhances the pro-apoptotic effect of anti-PD-L1 antibody both in vivo and in vitro in DLBCL." @default.
• W3129459286 created "2021-03-01" @default.
• W3129459286 creator A5000656988 @default.
• W3129459286 creator A5004726461 @default.
• W3129459286 creator A5021384155 @default.
• W3129459286 creator A5045207812 @default.
• W3129459286 creator A5064286400 @default.
• W3129459286 creator A5086675472 @default.
• W3129459286 date "2021-01-27" @default.
• W3129459286 modified "2023-09-26" @default.
• W3129459286 title "Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells" @default.
• W3129459286 cites W1971423772 @default.
• W3129459286 cites W1997294930 @default.
• W3129459286 cites W2020789296 @default.
• W3129459286 cites W2060713654 @default.
• W3129459286 cites W2081184407 @default.
• W3129459286 cites W2099556150 @default.
• W3129459286 cites W2105173404 @default.
• W3129459286 cites W2121332874 @default.
• W3129459286 cites W2125407494 @default.
• W3129459286 cites W2146226600 @default.
• W3129459286 cites W2155464214 @default.
• W3129459286 cites W2226913284 @default.
• W3129459286 cites W2412725897 @default.
• W3129459286 cites W2518920607 @default.
• W3129459286 cites W2523350566 @default.
• W3129459286 cites W2563775745 @default.
• W3129459286 cites W2593446177 @default.
• W3129459286 cites W2599353531 @default.
• W3129459286 cites W2612021596 @default.
• W3129459286 cites W2754056099 @default.
• W3129459286 cites W2790574591 @default.
• W3129459286 cites W2889016504 @default.
• W3129459286 cites W2889989292 @default.
• W3129459286 cites W2894963806 @default.
• W3129459286 cites W2911487711 @default.
• W3129459286 cites W2923864116 @default.
• W3129459286 cites W2940720857 @default.
• W3129459286 cites W2969778413 @default.
• W3129459286 cites W1969998568 @default.
• W3129459286 doi "https://doi.org/10.12659/msm.929431" @default.
• W3129459286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008972" @default.
• W3129459286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33764958" @default.
• W3129459286 hasPublicationYear "2021" @default.
• W3129459286 type Work @default.
• W3129459286 sameAs 3129459286 @default.
• W3129459286 citedByCount "5" @default.
• W3129459286 countsByYear W31294592862021 @default.
• W3129459286 countsByYear W31294592862022 @default.
• W3129459286 countsByYear W31294592862023 @default.
• W3129459286 crossrefType "journal-article" @default.
• W3129459286 hasAuthorship W3129459286A5000656988 @default.
• W3129459286 hasAuthorship W3129459286A5004726461 @default.
• W3129459286 hasAuthorship W3129459286A5021384155 @default.
• W3129459286 hasAuthorship W3129459286A5045207812 @default.
• W3129459286 hasAuthorship W3129459286A5064286400 @default.
• W3129459286 hasAuthorship W3129459286A5086675472 @default.
• W3129459286 hasBestOaLocation W31294592862 @default.
• W3129459286 hasConcept C153911025 @default.
• W3129459286 hasConcept C173396325 @default.
• W3129459286 hasConcept C185592680 @default.
• W3129459286 hasConcept C190232843 @default.
• W3129459286 hasConcept C190283241 @default.
• W3129459286 hasConcept C199835354 @default.
• W3129459286 hasConcept C2775975398 @default.
• W3129459286 hasConcept C29537977 @default.
• W3129459286 hasConcept C502942594 @default.
• W3129459286 hasConcept C55493867 @default.
• W3129459286 hasConcept C62112901 @default.
• W3129459286 hasConcept C86803240 @default.
• W3129459286 hasConceptScore W3129459286C153911025 @default.
• W3129459286 hasConceptScore W3129459286C173396325 @default.
• W3129459286 hasConceptScore W3129459286C185592680 @default.
• W3129459286 hasConceptScore W3129459286C190232843 @default.
• W3129459286 hasConceptScore W3129459286C190283241 @default.
• W3129459286 hasConceptScore W3129459286C199835354 @default.
• W3129459286 hasConceptScore W3129459286C2775975398 @default.
• W3129459286 hasConceptScore W3129459286C29537977 @default.
• W3129459286 hasConceptScore W3129459286C502942594 @default.
• W3129459286 hasConceptScore W3129459286C55493867 @default.
• W3129459286 hasConceptScore W3129459286C62112901 @default.
• W3129459286 hasConceptScore W3129459286C86803240 @default.
• W3129459286 hasLocation W31294592861 @default.
• W3129459286 hasLocation W31294592862 @default.
• W3129459286 hasOpenAccess W3129459286 @default.
• W3129459286 hasPrimaryLocation W31294592861 @default.
• W3129459286 hasRelatedWork W1978206894 @default.
• W3129459286 hasRelatedWork W1982414245 @default.
• W3129459286 hasRelatedWork W2159271922 @default.
• W3129459286 hasRelatedWork W2185175380 @default.
• W3129459286 hasRelatedWork W2383691845 @default.
• W3129459286 hasRelatedWork W2494327966 @default.
• W3129459286 hasRelatedWork W2586385055 @default.
• W3129459286 hasRelatedWork W2699522849 @default.
• W3129459286 hasRelatedWork W3130220624 @default.
• W3129459286 hasRelatedWork W4242373210 @default.
• W3129459286 hasVolume "27" @default.
• W3129459286 isParatext "false" @default.
• W3129459286 isRetracted "false" @default.
• W3129459286 magId "3129459286" @default.

• next