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• W3129471640 abstract "Abstract During cellular differentiation chromosome conformation is intricately remodelled to support the lineage-specific transcriptional programs required for initiating and maintaining lineage identity. When these changes occur in relation to cell cycle, division and time in response to cellular activation and differentiation signals has yet to be explored, although it has been proposed to occur during DNA synthesis or after mitosis. Here, we elucidate the chromosome conformational changes in B lymphocytes as they differentiate and expand from a naive, quiescent state into antibody secreting plasma cells. We find gene-regulatory chromosome reorganization in late G1 phase before the first division, and that this configuration is remarkably stable as the cells massively and rapidly clonally expand. A second wave of conformational change occurs as cells terminally differentiate into plasma cells, coincident with increased time in G1 phase. These results provide further explanation for how lymphocyte fate is imprinted prior to the first division. They also suggest that chromosome reconfiguration occurs prior to DNA replication and mitosis, and is linked to a gene expression program that controls the differentiation process required for the generation of immunity." @default.
• W3129471640 created "2021-03-01" @default.
• W3129471640 creator A5003796244 @default.
• W3129471640 creator A5013717719 @default.
• W3129471640 creator A5019232233 @default.
• W3129471640 creator A5043291271 @default.
• W3129471640 creator A5053608981 @default.
• W3129471640 creator A5060561576 @default.
• W3129471640 creator A5071725155 @default.
• W3129471640 creator A5081287556 @default.
• W3129471640 creator A5084034730 @default.
• W3129471640 date "2021-02-26" @default.
• W3129471640 modified "2023-10-18" @default.
• W3129471640 title "Pre-mitotic genome re-organisation bookends the B cell differentiation process" @default.
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