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- W3129487631 abstract "Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO grade IV gliomas (glioblastomas, GBM) will recur locally within 2 years. For patients with recurrent GBM, no standard of care exists. Thanks to the continuous improvement in radiation science and technology, reirradiation has emerged as feasible approach for patients with brain tumors. Using stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT), either hypofractionated or conventionally fractionated schedules, several studies have suggested survival benefits following reirradiation of patients with recurrent GBM; however, there are still questions to be answered about the efficacy and toxicity associated with a second course of radiation. We provide a clinical overview on current status and recent advances in reirradiation of GBM, addressing relevant clinical questions such as the appropriate patient selection and radiation technique, optimal dose fractionation, reirradiation tolerance of the brain and the risk of radiation necrosis." @default.
- W3129487631 created "2021-03-01" @default.
- W3129487631 creator A5011844809 @default.
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- W3129487631 creator A5038323479 @default.
- W3129487631 creator A5065547065 @default.
- W3129487631 creator A5080572439 @default.
- W3129487631 date "2021-02-18" @default.
- W3129487631 modified "2023-10-18" @default.
- W3129487631 title "Current status and recent advances in reirradiation of glioblastoma" @default.
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