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• W3129536098 endingPage "108490" @default.
• W3129536098 startingPage "108490" @default.
• W3129536098 abstract "3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has been shown to produce serotonergic damage in the brains of primates, including humans, and of rats. Tryptophan, the precursor of serotonin, is primarily degraded through the kynurenine (KYN) pathway, producing among others KYN, the main metabolite of this route. KYN has been reported as an endogenous agonist of the aryl hydrocarbon receptor (AhR), a transcription factor involved in several neurological functions. This study aims to determine the effect of MDMA on the KYN pathway and on AhR activity and to establish their role in the long-term serotonergic neurotoxicity induced by the drug in rats. Our results show that MDMA induces the activation of the KYN pathway, mediated by hepatic tryptophan 2,3-dioxygenase (TDO). MDMA also activated AhR as evidenced by increased AhR nuclear translocation and CYP1B1 mRNA expression. Autoradiographic quantification of serotonin transporters showed that both the TDO inhibitor 680C91 and the AhR antagonist CH-223191 potentiated the neurotoxicity induced by MDMA, while administration of exogenous l-kynurenine or of the AhR positive modulator 3,3'-diindolylmethane (DIM) partially prevented the serotonergic damage induced by the drug. The results demonstrate for the first time that MDMA increases KYN levels and AhR activity, and these changes appear to play a role in limiting the neurotoxicity induced by the drug. This work provides a better understanding of the physiological mechanisms that attenuate the brain damage induced by MDMA and identify modulation of the KYN pathway and of AhR as potential therapeutic strategies to limit the negative effects of MDMA." @default.
• W3129536098 created "2021-03-01" @default.
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• W3129536098 date "2021-04-01" @default.
• W3129536098 modified "2023-10-09" @default.
• W3129536098 title "Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor" @default.
• W3129536098 cites W1517515257 @default.
• W3129536098 cites W1562529961 @default.
• W3129536098 cites W1574496069 @default.
• W3129536098 cites W1580449107 @default.
• W3129536098 cites W1798211609 @default.
• W3129536098 cites W1862179121 @default.
• W3129536098 cites W1917614605 @default.
• W3129536098 cites W1944697741 @default.
• W3129536098 cites W1966157390 @default.
• W3129536098 cites W1978203828 @default.
• W3129536098 cites W1984241984 @default.
• W3129536098 cites W1985118788 @default.
• W3129536098 cites W1993693624 @default.
• W3129536098 cites W1998142996 @default.
• W3129536098 cites W2001276295 @default.
• W3129536098 cites W2001520420 @default.
• W3129536098 cites W2004082394 @default.
• W3129536098 cites W2006334693 @default.
• W3129536098 cites W2007906048 @default.
• W3129536098 cites W2012252010 @default.
• W3129536098 cites W2016730049 @default.
• W3129536098 cites W2016920671 @default.
• W3129536098 cites W2017124867 @default.
• W3129536098 cites W2019072693 @default.
• W3129536098 cites W2021367537 @default.
• W3129536098 cites W2028833397 @default.
• W3129536098 cites W2031053532 @default.
• W3129536098 cites W2031616074 @default.
• W3129536098 cites W2046678045 @default.
• W3129536098 cites W2047900740 @default.
• W3129536098 cites W2049804872 @default.
• W3129536098 cites W2052027317 @default.
• W3129536098 cites W2053124968 @default.
• W3129536098 cites W2060050678 @default.
• W3129536098 cites W2067092746 @default.
• W3129536098 cites W2070720851 @default.
• W3129536098 cites W2076216033 @default.
• W3129536098 cites W2078267752 @default.
• W3129536098 cites W2079814518 @default.
• W3129536098 cites W2085301448 @default.
• W3129536098 cites W2085540133 @default.
• W3129536098 cites W2090344479 @default.
• W3129536098 cites W2097144774 @default.
• W3129536098 cites W2101445441 @default.
• W3129536098 cites W2103323995 @default.
• W3129536098 cites W2103553504 @default.
• W3129536098 cites W2103747432 @default.
• W3129536098 cites W2104053304 @default.
• W3129536098 cites W2107790349 @default.
• W3129536098 cites W2107944892 @default.
• W3129536098 cites W2108846054 @default.
• W3129536098 cites W2122383036 @default.
• W3129536098 cites W2131278093 @default.
• W3129536098 cites W2132011757 @default.
• W3129536098 cites W2132758130 @default.
• W3129536098 cites W2144321957 @default.
• W3129536098 cites W2151197941 @default.
• W3129536098 cites W2163752139 @default.
• W3129536098 cites W2168194391 @default.
• W3129536098 cites W2192218028 @default.
• W3129536098 cites W2345604850 @default.
• W3129536098 cites W2594356897 @default.
• W3129536098 cites W2598111690 @default.
• W3129536098 cites W2730312060 @default.
• W3129536098 cites W2741302852 @default.
• W3129536098 cites W2763160800 @default.
• W3129536098 cites W2769818061 @default.
• W3129536098 cites W2770886817 @default.
• W3129536098 cites W2791364631 @default.
• W3129536098 cites W2799742551 @default.
• W3129536098 cites W2802337530 @default.
• W3129536098 cites W2803938554 @default.
• W3129536098 cites W2803974369 @default.
• W3129536098 cites W2888696264 @default.
• W3129536098 cites W2911968308 @default.
• W3129536098 cites W2923355729 @default.
• W3129536098 cites W3016549119 @default.
• W3129536098 cites W73335709 @default.
• W3129536098 doi "https://doi.org/10.1016/j.neuropharm.2021.108490" @default.
• W3129536098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33607146" @default.
• W3129536098 hasPublicationYear "2021" @default.
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