FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129581973> ?p ?o ?g. }

• W3129581973 abstract "Long-term natural and artificial selection leads to change in certain regions of the genome, resulting in selection signatures that can reveal genes associated with selected traits, such as horns (i.e., polled/horned), high-quality wool traits, and high-altitude hypoxia adaptability. These are complex traits determined by multiple genes, regulatory pathways, and environmental factors. A list of genes with considerable effects on horn and adaptability traits has not been found, although multiple quantitative trait loci (QTL) have been identified. Selection signatures could be identified using genetic differentiation (F ST ), polymorphism levels θπ, and Tajima’s D. This study aimed to identify selection signatures in fine-wool sheep and to investigate the genes annotated in these regions, as well as the biological pathways involved in horn and adaptability traits. For this purpose, the whole-genome sequence of 120 individuals from four breeds, which come from different elevations and habitats in China, was used to analyze selection signatures for horn and adaptability traits. Annotation of the consensus regions of F ST and θπ ratios revealed a list of identified genes associated with polled/horned and high-altitude hypoxia adaptability traits, such as RXPF2 , EE RFC4 , MSH6 , PP1R12A , THBS1 , ATP1B2 , RYR2 , and PLA2G2E . Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified genes related primarily to mismatch repair, metabolism, vascular smooth muscle contraction, and cardiac muscle contraction. This is the first study to demonstrate that selection signatures play an important role in the polled/horned and high-altitude hypoxia adaptability traits of fine-wool sheep breeds that have undergone high-intensity selection and adapted to different ecological environments in China. Changes observed in the genome of fine-wool sheep may have acted on genomic regions that affect performance traits and provide a reference for genome design and breeding." @default.
• W3129581973 created "2021-03-01" @default.
• W3129581973 creator A5001371066 @default.
• W3129581973 creator A5010250466 @default.
• W3129581973 creator A5016988612 @default.
• W3129581973 creator A5024082171 @default.
• W3129581973 creator A5029652304 @default.
• W3129581973 creator A5030505670 @default.
• W3129581973 creator A5038868843 @default.
• W3129581973 creator A5050577040 @default.
• W3129581973 creator A5060186258 @default.
• W3129581973 creator A5064133718 @default.
• W3129581973 creator A5066028215 @default.
• W3129581973 creator A5076234252 @default.
• W3129581973 creator A5078008359 @default.
• W3129581973 creator A5078880944 @default.
• W3129581973 date "2021-02-23" @default.
• W3129581973 modified "2023-10-12" @default.
• W3129581973 title "Selective Sweeps Uncovering the Genetic Basis of Horn and Adaptability Traits on Fine-Wool Sheep in China" @default.
• W3129581973 cites W1493570549 @default.
• W3129581973 cites W1559477917 @default.
• W3129581973 cites W1917632130 @default.
• W3129581973 cites W1970519791 @default.
• W3129581973 cites W1981759085 @default.
• W3129581973 cites W1984068087 @default.
• W3129581973 cites W1984390786 @default.
• W3129581973 cites W1989551904 @default.
• W3129581973 cites W1991301405 @default.
• W3129581973 cites W1995865454 @default.
• W3129581973 cites W1996080723 @default.
• W3129581973 cites W1997476591 @default.
• W3129581973 cites W1999623479 @default.
• W3129581973 cites W2000510816 @default.
• W3129581973 cites W2027496182 @default.
• W3129581973 cites W2033754587 @default.
• W3129581973 cites W2034150855 @default.
• W3129581973 cites W2047366062 @default.
• W3129581973 cites W2050841265 @default.
• W3129581973 cites W2052414168 @default.
• W3129581973 cites W2056870028 @default.
• W3129581973 cites W2062290915 @default.
• W3129581973 cites W2063571399 @default.
• W3129581973 cites W2068832995 @default.
• W3129581973 cites W2075183916 @default.
• W3129581973 cites W2082967637 @default.
• W3129581973 cites W2096585111 @default.
• W3129581973 cites W2100482242 @default.
• W3129581973 cites W2103337472 @default.
• W3129581973 cites W2103441770 @default.
• W3129581973 cites W2103604860 @default.
• W3129581973 cites W2106775542 @default.
• W3129581973 cites W2108169091 @default.
• W3129581973 cites W2108234281 @default.
• W3129581973 cites W2111629801 @default.
• W3129581973 cites W2114278514 @default.
• W3129581973 cites W2120721738 @default.
• W3129581973 cites W2124208240 @default.
• W3129581973 cites W2139752884 @default.
• W3129581973 cites W2142138981 @default.
• W3129581973 cites W2149597669 @default.
• W3129581973 cites W2150536115 @default.
• W3129581973 cites W2154096947 @default.
• W3129581973 cites W2156697481 @default.
• W3129581973 cites W2161633633 @default.
• W3129581973 cites W2162530578 @default.
• W3129581973 cites W2163027529 @default.
• W3129581973 cites W2164299185 @default.
• W3129581973 cites W2202173306 @default.
• W3129581973 cites W2556359743 @default.
• W3129581973 cites W2586156403 @default.
• W3129581973 cites W2980156059 @default.
• W3129581973 cites W2981518188 @default.
• W3129581973 cites W3013081652 @default.
• W3129581973 cites W901216539 @default.
• W3129581973 doi "https://doi.org/10.3389/fgene.2021.604235" @default.
• W3129581973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7940688" @default.
• W3129581973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33708236" @default.
• W3129581973 hasPublicationYear "2021" @default.
• W3129581973 type Work @default.
• W3129581973 sameAs 3129581973 @default.
• W3129581973 citedByCount "2" @default.
• W3129581973 countsByYear W31295819732022 @default.
• W3129581973 countsByYear W31295819732023 @default.
• W3129581973 crossrefType "journal-article" @default.
• W3129581973 hasAuthorship W3129581973A5001371066 @default.
• W3129581973 hasAuthorship W3129581973A5010250466 @default.
• W3129581973 hasAuthorship W3129581973A5016988612 @default.
• W3129581973 hasAuthorship W3129581973A5024082171 @default.
• W3129581973 hasAuthorship W3129581973A5029652304 @default.
• W3129581973 hasAuthorship W3129581973A5030505670 @default.
• W3129581973 hasAuthorship W3129581973A5038868843 @default.
• W3129581973 hasAuthorship W3129581973A5050577040 @default.
• W3129581973 hasAuthorship W3129581973A5060186258 @default.
• W3129581973 hasAuthorship W3129581973A5064133718 @default.
• W3129581973 hasAuthorship W3129581973A5066028215 @default.
• W3129581973 hasAuthorship W3129581973A5076234252 @default.
• W3129581973 hasAuthorship W3129581973A5078008359 @default.
• W3129581973 hasAuthorship W3129581973A5078880944 @default.
• W3129581973 hasBestOaLocation W31295819731 @default.
• W3129581973 hasConcept C104317684 @default.

• next