FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129598367> ?p ?o ?g. }

• W3129598367 abstract "Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response. GR dimerization-dependent gene regulation is essential for the anti-inflammatory effects of GCs. Therefore, we investigated in a murine trauma model of combined femur fracture and thoracic trauma, whether effective GR dimerization influences the pathomechanisms of trauma-induced compromised fracture healing. To this end, we used mice with decreased GR dimerization ability (GR dim ). The healing process was analyzed by cytokine/chemokine multiplex analysis, flow cytometry, gene-expression analysis, histomorphometry, micro-computed tomography, and biomechanical testing. GR dim mice did not display a systemic or local hyper-inflammation upon combined fracture and thorax trauma. Strikingly, we discovered that GR dim mice were protected from fracture healing impairment induced by the additional thorax trauma. Collectively and in contrast to previous studies describing the beneficial effects of intact GR dimerization in inflammatory models, we report here an adverse role of intact GR dimerization in trauma-induced compromised fracture healing." @default.
• W3129598367 created "2021-03-01" @default.
• W3129598367 creator A5003694440 @default.
• W3129598367 creator A5008685431 @default.
• W3129598367 creator A5015396351 @default.
• W3129598367 creator A5038904691 @default.
• W3129598367 creator A5042483283 @default.
• W3129598367 creator A5065496991 @default.
• W3129598367 creator A5078087984 @default.
• W3129598367 creator A5086279896 @default.
• W3129598367 date "2021-02-17" @default.
• W3129598367 modified "2023-09-24" @default.
• W3129598367 title "Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing" @default.
• W3129598367 cites W1781042489 @default.
• W3129598367 cites W1841551052 @default.
• W3129598367 cites W1966296500 @default.
• W3129598367 cites W1975924574 @default.
• W3129598367 cites W1983801143 @default.
• W3129598367 cites W1986978782 @default.
• W3129598367 cites W1997510672 @default.
• W3129598367 cites W2002481407 @default.
• W3129598367 cites W2003936181 @default.
• W3129598367 cites W2011203192 @default.
• W3129598367 cites W2017778044 @default.
• W3129598367 cites W2018521741 @default.
• W3129598367 cites W2021443622 @default.
• W3129598367 cites W2023100874 @default.
• W3129598367 cites W2027059464 @default.
• W3129598367 cites W2029453794 @default.
• W3129598367 cites W2045008807 @default.
• W3129598367 cites W2049670746 @default.
• W3129598367 cites W2054409221 @default.
• W3129598367 cites W2060003909 @default.
• W3129598367 cites W2060990402 @default.
• W3129598367 cites W2065384730 @default.
• W3129598367 cites W2065742608 @default.
• W3129598367 cites W2066022850 @default.
• W3129598367 cites W2072293269 @default.
• W3129598367 cites W2074504029 @default.
• W3129598367 cites W2079533675 @default.
• W3129598367 cites W2085626537 @default.
• W3129598367 cites W2089953523 @default.
• W3129598367 cites W2094760828 @default.
• W3129598367 cites W2096425957 @default.
• W3129598367 cites W2098522805 @default.
• W3129598367 cites W2100185747 @default.
• W3129598367 cites W2103684286 @default.
• W3129598367 cites W2132134302 @default.
• W3129598367 cites W2148685973 @default.
• W3129598367 cites W2167807351 @default.
• W3129598367 cites W2255006398 @default.
• W3129598367 cites W2272492043 @default.
• W3129598367 cites W2292034152 @default.
• W3129598367 cites W2315449569 @default.
• W3129598367 cites W2477744220 @default.
• W3129598367 cites W2510454213 @default.
• W3129598367 cites W2752984482 @default.
• W3129598367 cites W2769351021 @default.
• W3129598367 cites W2771055284 @default.
• W3129598367 cites W2773136751 @default.
• W3129598367 cites W2789334209 @default.
• W3129598367 cites W2791662391 @default.
• W3129598367 cites W2802034197 @default.
• W3129598367 cites W2805722225 @default.
• W3129598367 cites W2850263944 @default.
• W3129598367 cites W2902688795 @default.
• W3129598367 cites W2921589813 @default.
• W3129598367 cites W2963377137 @default.
• W3129598367 cites W2980965559 @default.
• W3129598367 cites W4235657941 @default.
• W3129598367 cites W67215717 @default.
• W3129598367 doi "https://doi.org/10.3389/fimmu.2020.628287" @default.
• W3129598367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7927427" @default.
• W3129598367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33679723" @default.
• W3129598367 hasPublicationYear "2021" @default.
• W3129598367 type Work @default.
• W3129598367 sameAs 3129598367 @default.
• W3129598367 citedByCount "4" @default.
• W3129598367 countsByYear W31295983672022 @default.
• W3129598367 crossrefType "journal-article" @default.
• W3129598367 hasAuthorship W3129598367A5003694440 @default.
• W3129598367 hasAuthorship W3129598367A5008685431 @default.
• W3129598367 hasAuthorship W3129598367A5015396351 @default.
• W3129598367 hasAuthorship W3129598367A5038904691 @default.
• W3129598367 hasAuthorship W3129598367A5042483283 @default.
• W3129598367 hasAuthorship W3129598367A5065496991 @default.
• W3129598367 hasAuthorship W3129598367A5078087984 @default.
• W3129598367 hasAuthorship W3129598367A5086279896 @default.
• W3129598367 hasBestOaLocation W31295983671 @default.
• W3129598367 hasConcept C13373296 @default.
• W3129598367 hasConcept C141071460 @default.
• W3129598367 hasConcept C142724271 @default.
• W3129598367 hasConcept C203014093 @default.
• W3129598367 hasConcept C2776252253 @default.
• W3129598367 hasConcept C2776914184 @default.
• W3129598367 hasConcept C2780554211 @default.
• W3129598367 hasConcept C2780841215 @default.
• W3129598367 hasConcept C2992660301 @default.
• W3129598367 hasConcept C59493245 @default.
• W3129598367 hasConcept C71924100 @default.

• next