Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129602947> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3129602947 endingPage "502" @default.
- W3129602947 startingPage "499" @default.
- W3129602947 abstract "Objective: To investigate the preventive and therapeutic effects of Qiwei Yugan Granule (QYG) on hepatic fibrosis in rats based on MMP-13/TIMP-1 imbalance. Methods: The rats were randomly divided into control group, model group, colchicine group (1.0×10-4 g/kg) and QYG treated groups (3.7, 7.4, 14.8 g/kg) (n=8). The rat model of hepatic fibrosis was established by injected with carbon tetrachloride subcutaneously for 4 weeks and treated with ethanol by gavage for 6 weeks. The effects of QYG on liver function, histopathology of liver, related indexes of serum liver fibrosis, and MMP-13, TIMP-1 in hepatic tissue were observed. Results: QYG at the doses of 14.8、7.4、3.7 g/kg could significantly decrease the serum levels of ALT, AST, HA, PCⅢ and C-Ⅳ, relieve the pathological changes of hepatic fibrosis, increase the activity of MMP-13, decrease the activity of TIMP-1 and alleviate the imbalance of MMP-13/TIMP-1. Among them, QYG had a certain trend of dose-effect relationship with TIMP-1 and MMP-13/TIMP-1 (P＜0.05, 0.01). Conclusion: QYG has the effect of preventing and treating liver fibrosis and one of mechanisms is to promote MMP-13/TIMP-1 to restore balance." @default.
- W3129602947 created "2021-03-01" @default.
- W3129602947 creator A5002522403 @default.
- W3129602947 creator A5032191059 @default.
- W3129602947 creator A5044705802 @default.
- W3129602947 creator A5064270666 @default.
- W3129602947 creator A5068377743 @default.
- W3129602947 creator A5068512326 @default.
- W3129602947 date "2020-09-01" @default.
- W3129602947 modified "2023-09-27" @default.
- W3129602947 title "Preventive and therapeutic effects of Qiwei Yugan Granule on hepatic fibrosis in rats" @default.
- W3129602947 doi "https://doi.org/10.12047/j.cjap.6005.2020.106" @default.
- W3129602947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33629566" @default.
- W3129602947 hasPublicationYear "2020" @default.
- W3129602947 type Work @default.
- W3129602947 sameAs 3129602947 @default.
- W3129602947 citedByCount "0" @default.
- W3129602947 crossrefType "journal-article" @default.
- W3129602947 hasAuthorship W3129602947A5002522403 @default.
- W3129602947 hasAuthorship W3129602947A5032191059 @default.
- W3129602947 hasAuthorship W3129602947A5044705802 @default.
- W3129602947 hasAuthorship W3129602947A5064270666 @default.
- W3129602947 hasAuthorship W3129602947A5068377743 @default.
- W3129602947 hasAuthorship W3129602947A5068512326 @default.
- W3129602947 hasConcept C102124568 @default.
- W3129602947 hasConcept C102652120 @default.
- W3129602947 hasConcept C109523444 @default.
- W3129602947 hasConcept C126322002 @default.
- W3129602947 hasConcept C134018914 @default.
- W3129602947 hasConcept C142724271 @default.
- W3129602947 hasConcept C178790620 @default.
- W3129602947 hasConcept C185592680 @default.
- W3129602947 hasConcept C207886595 @default.
- W3129602947 hasConcept C2776636253 @default.
- W3129602947 hasConcept C2777359374 @default.
- W3129602947 hasConcept C2780559512 @default.
- W3129602947 hasConcept C2992208098 @default.
- W3129602947 hasConcept C2993667909 @default.
- W3129602947 hasConcept C544855455 @default.
- W3129602947 hasConcept C71924100 @default.
- W3129602947 hasConcept C90924648 @default.
- W3129602947 hasConceptScore W3129602947C102124568 @default.
- W3129602947 hasConceptScore W3129602947C102652120 @default.
- W3129602947 hasConceptScore W3129602947C109523444 @default.
- W3129602947 hasConceptScore W3129602947C126322002 @default.
- W3129602947 hasConceptScore W3129602947C134018914 @default.
- W3129602947 hasConceptScore W3129602947C142724271 @default.
- W3129602947 hasConceptScore W3129602947C178790620 @default.
- W3129602947 hasConceptScore W3129602947C185592680 @default.
- W3129602947 hasConceptScore W3129602947C207886595 @default.
- W3129602947 hasConceptScore W3129602947C2776636253 @default.
- W3129602947 hasConceptScore W3129602947C2777359374 @default.
- W3129602947 hasConceptScore W3129602947C2780559512 @default.
- W3129602947 hasConceptScore W3129602947C2992208098 @default.
- W3129602947 hasConceptScore W3129602947C2993667909 @default.
- W3129602947 hasConceptScore W3129602947C544855455 @default.
- W3129602947 hasConceptScore W3129602947C71924100 @default.
- W3129602947 hasConceptScore W3129602947C90924648 @default.
- W3129602947 hasIssue "5" @default.
- W3129602947 hasLocation W31296029471 @default.
- W3129602947 hasOpenAccess W3129602947 @default.
- W3129602947 hasPrimaryLocation W31296029471 @default.
- W3129602947 hasRelatedWork W1934931739 @default.
- W3129602947 hasRelatedWork W1974036212 @default.
- W3129602947 hasRelatedWork W2040885538 @default.
- W3129602947 hasRelatedWork W2325922987 @default.
- W3129602947 hasRelatedWork W2351108972 @default.
- W3129602947 hasRelatedWork W2355906679 @default.
- W3129602947 hasRelatedWork W2358776910 @default.
- W3129602947 hasRelatedWork W2366728761 @default.
- W3129602947 hasRelatedWork W2371476078 @default.
- W3129602947 hasRelatedWork W2371585653 @default.
- W3129602947 hasRelatedWork W2372070736 @default.
- W3129602947 hasRelatedWork W2378432359 @default.
- W3129602947 hasRelatedWork W2383042639 @default.
- W3129602947 hasRelatedWork W2385349807 @default.
- W3129602947 hasRelatedWork W2386132422 @default.
- W3129602947 hasRelatedWork W2386611226 @default.
- W3129602947 hasRelatedWork W2388482399 @default.
- W3129602947 hasRelatedWork W2389120736 @default.
- W3129602947 hasRelatedWork W3047930825 @default.
- W3129602947 hasRelatedWork W3214360370 @default.
- W3129602947 hasVolume "36" @default.
- W3129602947 isParatext "false" @default.
- W3129602947 isRetracted "false" @default.
- W3129602947 magId "3129602947" @default.
- W3129602947 workType "article" @default.