FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W312962009> ?p ?o ?g. }

• W312962009 endingPage "1072" @default.
• W312962009 startingPage "1072" @default.
• W312962009 abstract "To study the modulating effect of GdCl(3) and Angelica Sinensis polysaccharides (ASP) on differentially expressed genes in liver of hepatic immunological mice by cDNA microarray.Hepatic immunological injury was induced by lipopolysaccharide (LPS ip, 0.2 mg/kg(-1)) in bacillus calmetteguerin (BCG ip, 1 mg/kg(-1)) primed mice; A single dose of 20 mg/kg(-1) GdCl(3) was simultaneously pretreated and 30 mg/kg(-1) ASP (ig, qdX7 d) was administrated when the BCG+LPS was primed. The mice were sacrificed at the end of the 7(th) day after ip LPS for 6 h and the liver was removed quickly. The PCR products of 512 genes were spotted onto a chemical material-coated glass plate in array. The DNAs were fixed to the glass plate after series of treatments. The total RNAs were isolated from the liver tissue, and were purified to mRNAs by Oligotex. Both mRNAs from the normal liver tissue and the liver tissue from the mice with hepatic immunological injury or that pretreated with GdCl(3) or ASP were reversely transcribed to cDNAs with the incorporation of fluorescent dUTP to prepare the hybridization probes. The mixed probes were hybridized to the cDNA microarray. After high-stringent washing, the cDNA microarray was scanned for fluorescent signals and showed differences between the two tissues.Among the 512 target genes, 18 differed in liver tissue of hepatic immunological injury mice, and 6 differed in those pretreated by ASP, 7 differed in those pretreated by GdCl(3).cDNA microarray technique is effective in screening the differentially expressed genes between two different kinds of tissue. Further analysis of those obtained genes will be helpful to understand the molecular mechanism of hepatic immunological injury and to study the intervention of drug. Both ASP and GdCl(3) can decrease the number of the differentially expressed genes in liver tissue of mice with hepatic immunological injury." @default.
• W312962009 created "2016-06-24" @default.
• W312962009 creator A5027044037 @default.
• W312962009 creator A5043089487 @default.
• W312962009 creator A5056744141 @default.
• W312962009 creator A5060282209 @default.
• W312962009 creator A5085943321 @default.
• W312962009 date "2003-01-01" @default.
• W312962009 modified "2023-10-18" @default.
• W312962009 title "Modulation of GdCl₃and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray" @default.
• W312962009 cites W116062262 @default.
• W312962009 cites W1500302147 @default.
• W312962009 cites W1561633977 @default.
• W312962009 cites W1932990974 @default.
• W312962009 cites W1964397161 @default.
• W312962009 cites W1964610199 @default.
• W312962009 cites W1988934983 @default.
• W312962009 cites W1993170236 @default.
• W312962009 cites W1994468555 @default.
• W312962009 cites W2003407908 @default.
• W312962009 cites W2007477730 @default.
• W312962009 cites W2011624265 @default.
• W312962009 cites W2022543801 @default.
• W312962009 cites W2026855648 @default.
• W312962009 cites W2034248880 @default.
• W312962009 cites W2037508044 @default.
• W312962009 cites W2041245086 @default.
• W312962009 cites W2043408480 @default.
• W312962009 cites W2063451083 @default.
• W312962009 cites W2066093128 @default.
• W312962009 cites W2069094021 @default.
• W312962009 cites W2070697315 @default.
• W312962009 cites W2109259678 @default.
• W312962009 cites W2126273331 @default.
• W312962009 cites W2126291393 @default.
• W312962009 cites W2157089603 @default.
• W312962009 cites W2158306079 @default.
• W312962009 cites W2158567066 @default.
• W312962009 cites W2159941442 @default.
• W312962009 cites W2161893150 @default.
• W312962009 cites W2165011536 @default.
• W312962009 cites W2169741256 @default.
• W312962009 cites W2221275079 @default.
• W312962009 cites W2405620704 @default.
• W312962009 cites W2443487756 @default.
• W312962009 cites W3011275316 @default.
• W312962009 cites W4237473716 @default.
• W312962009 doi "https://doi.org/10.3748/wjg.v9.i5.1072" @default.
• W312962009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4611375" @default.
• W312962009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12717859" @default.
• W312962009 hasPublicationYear "2003" @default.
• W312962009 type Work @default.
• W312962009 sameAs 312962009 @default.
• W312962009 citedByCount "8" @default.
• W312962009 countsByYear W3129620092012 @default.
• W312962009 countsByYear W3129620092020 @default.
• W312962009 countsByYear W3129620092022 @default.
• W312962009 countsByYear W3129620092023 @default.
• W312962009 crossrefType "journal-article" @default.
• W312962009 hasAuthorship W312962009A5027044037 @default.
• W312962009 hasAuthorship W312962009A5043089487 @default.
• W312962009 hasAuthorship W312962009A5056744141 @default.
• W312962009 hasAuthorship W312962009A5060282209 @default.
• W312962009 hasAuthorship W312962009A5085943321 @default.
• W312962009 hasBestOaLocation W3129620091 @default.
• W312962009 hasConcept C104317684 @default.
• W312962009 hasConcept C134018914 @default.
• W312962009 hasConcept C150194340 @default.
• W312962009 hasConcept C153911025 @default.
• W312962009 hasConcept C186836561 @default.
• W312962009 hasConcept C187882448 @default.
• W312962009 hasConcept C203014093 @default.
• W312962009 hasConcept C2776637226 @default.
• W312962009 hasConcept C2778754761 @default.
• W312962009 hasConcept C55493867 @default.
• W312962009 hasConcept C8415881 @default.
• W312962009 hasConcept C86803240 @default.
• W312962009 hasConceptScore W312962009C104317684 @default.
• W312962009 hasConceptScore W312962009C134018914 @default.
• W312962009 hasConceptScore W312962009C150194340 @default.
• W312962009 hasConceptScore W312962009C153911025 @default.
• W312962009 hasConceptScore W312962009C186836561 @default.
• W312962009 hasConceptScore W312962009C187882448 @default.
• W312962009 hasConceptScore W312962009C203014093 @default.
• W312962009 hasConceptScore W312962009C2776637226 @default.
• W312962009 hasConceptScore W312962009C2778754761 @default.
• W312962009 hasConceptScore W312962009C55493867 @default.
• W312962009 hasConceptScore W312962009C8415881 @default.
• W312962009 hasConceptScore W312962009C86803240 @default.
• W312962009 hasIssue "5" @default.
• W312962009 hasLocation W3129620091 @default.
• W312962009 hasLocation W3129620092 @default.
• W312962009 hasLocation W3129620093 @default.
• W312962009 hasLocation W3129620094 @default.
• W312962009 hasOpenAccess W312962009 @default.
• W312962009 hasPrimaryLocation W3129620091 @default.
• W312962009 hasRelatedWork W2359571707 @default.
• W312962009 hasRelatedWork W2361105963 @default.

• next