Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129638514> ?p ?o ?g. }
- W3129638514 endingPage "e202000908" @default.
- W3129638514 startingPage "e202000908" @default.
- W3129638514 abstract "DCs play a vital role in immunity by conveying antigens from peripheral tissues to draining lymph nodes, through afferent lymphatic vessels. Critical to the process is initial docking to the lymphatic endothelial receptor LYVE-1 via its ligand hyaluronan on the DC surface. How this relatively weak binding polymer is configured for specific adhesion to LYVE-1, however, is unknown. Here, we show that hyaluronan is anchored and spatially organized into a 400–500 nm dense glycocalyx by the leukocyte receptor CD44. Using gene knockout and by modulating CD44-hyaluronan interactions with monoclonal antibodies in vitro and in a mouse model of oxazolone-induced skin inflammation, we demonstrate that CD44 is required for DC adhesion and transmigration across lymphatic endothelium. In addition, we present evidence that CD44 can dynamically control the density of the hyaluronan glycocalyx, regulating the efficiency of DC trafficking to lymph nodes. Our findings define a previously unrecognized role for CD44 in lymphatic trafficking and highlight the importance of the CD44:HA:LYVE-1 axis in its regulation." @default.
- W3129638514 created "2021-03-01" @default.
- W3129638514 creator A5025406860 @default.
- W3129638514 creator A5030823404 @default.
- W3129638514 creator A5062882861 @default.
- W3129638514 creator A5073935293 @default.
- W3129638514 date "2021-03-09" @default.
- W3129638514 modified "2023-09-25" @default.
- W3129638514 title "Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx" @default.
- W3129638514 cites W1488596745 @default.
- W3129638514 cites W1502078581 @default.
- W3129638514 cites W1518124028 @default.
- W3129638514 cites W1528888283 @default.
- W3129638514 cites W1534372645 @default.
- W3129638514 cites W1564861083 @default.
- W3129638514 cites W1935332540 @default.
- W3129638514 cites W1964851502 @default.
- W3129638514 cites W1970811697 @default.
- W3129638514 cites W1976241576 @default.
- W3129638514 cites W1976669132 @default.
- W3129638514 cites W1978944927 @default.
- W3129638514 cites W1980152518 @default.
- W3129638514 cites W1987329859 @default.
- W3129638514 cites W1988650452 @default.
- W3129638514 cites W1990917414 @default.
- W3129638514 cites W1993381419 @default.
- W3129638514 cites W2000547781 @default.
- W3129638514 cites W2004203577 @default.
- W3129638514 cites W2006123588 @default.
- W3129638514 cites W2006608487 @default.
- W3129638514 cites W2010080800 @default.
- W3129638514 cites W2026487158 @default.
- W3129638514 cites W2026927047 @default.
- W3129638514 cites W2027375557 @default.
- W3129638514 cites W2036143536 @default.
- W3129638514 cites W2043411450 @default.
- W3129638514 cites W2050644354 @default.
- W3129638514 cites W2052986295 @default.
- W3129638514 cites W2057267126 @default.
- W3129638514 cites W2060474417 @default.
- W3129638514 cites W2060563559 @default.
- W3129638514 cites W2062264071 @default.
- W3129638514 cites W2064617936 @default.
- W3129638514 cites W2065373309 @default.
- W3129638514 cites W2066307140 @default.
- W3129638514 cites W2071167287 @default.
- W3129638514 cites W2078468203 @default.
- W3129638514 cites W2080844302 @default.
- W3129638514 cites W2083832315 @default.
- W3129638514 cites W2088402590 @default.
- W3129638514 cites W2089491627 @default.
- W3129638514 cites W2092997355 @default.
- W3129638514 cites W2097863314 @default.
- W3129638514 cites W2098985768 @default.
- W3129638514 cites W2099126984 @default.
- W3129638514 cites W2099388162 @default.
- W3129638514 cites W2100322007 @default.
- W3129638514 cites W2109112909 @default.
- W3129638514 cites W2114539808 @default.
- W3129638514 cites W2123774138 @default.
- W3129638514 cites W2125000836 @default.
- W3129638514 cites W2134437854 @default.
- W3129638514 cites W2139082708 @default.
- W3129638514 cites W2139221355 @default.
- W3129638514 cites W2142669586 @default.
- W3129638514 cites W2145533255 @default.
- W3129638514 cites W2147448836 @default.
- W3129638514 cites W2148371571 @default.
- W3129638514 cites W2149057253 @default.
- W3129638514 cites W2150295492 @default.
- W3129638514 cites W2151172616 @default.
- W3129638514 cites W2152252241 @default.
- W3129638514 cites W2156918892 @default.
- W3129638514 cites W2158484702 @default.
- W3129638514 cites W2158659385 @default.
- W3129638514 cites W2158887647 @default.
- W3129638514 cites W2163380226 @default.
- W3129638514 cites W2163592912 @default.
- W3129638514 cites W2167704983 @default.
- W3129638514 cites W2263813704 @default.
- W3129638514 cites W2290737450 @default.
- W3129638514 cites W2483709802 @default.
- W3129638514 cites W2509147898 @default.
- W3129638514 cites W2527008427 @default.
- W3129638514 cites W2531882824 @default.
- W3129638514 cites W2580565990 @default.
- W3129638514 cites W2584088501 @default.
- W3129638514 cites W2596380881 @default.
- W3129638514 cites W2614673842 @default.
- W3129638514 cites W2787793662 @default.
- W3129638514 cites W2809616732 @default.
- W3129638514 cites W2887540568 @default.
- W3129638514 cites W2912161672 @default.
- W3129638514 cites W2920943674 @default.
- W3129638514 cites W2950866169 @default.
- W3129638514 cites W2979183324 @default.
- W3129638514 cites W3005212002 @default.
- W3129638514 cites W329188330 @default.