Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129646006> ?p ?o ?g. }
- W3129646006 endingPage "318" @default.
- W3129646006 startingPage "318" @default.
- W3129646006 abstract "Fuchs endothelial corneal dystrophy (FECD) is characterized by the gradual deterioration of corneal endothelial cells (CECs) and is the most common cause of corneal transplantation worldwide. CECs apoptosis caused by oxidative stress plays a pivotal role in the pathogenesis of FECD. Antioxidant compounds have been of considerable significance as a candidate treatment in the management of corneal diseases. Based on these findings, the objective of this study was to evaluate the effects of an aloe extract with antioxidant properties, in an “in vitro” model of FECD. Human corneal epithelial (HCE) cells were preincubated with aloe extract 100 μg/mL, two hours before hydrogen peroxide (H2O2) stimulus. H2O2 challenge significantly reduced the cell viability, increased the generation of Reactive Oxygen Species (ROS) and malondialdehyde levels. Moreover, m-RNA expression and activity of Nrf-2, Catalase and Superoxide dismutase (SOD) were reduced together with an enhanced expression of IL-1β, tumor necrosis factor-α (TNF-α), IL-6, and cyclooxygenase 2 (COX-2). Furthermore, Bcl-2, Caspase-3 and Caspase-8 expression were down-regulated while Bax was up-regulated by H2O2 stimulus. Aloe extract blunted the oxidative stress-induced inflammatory cascade triggered by H2O2 and modulated apoptosis. Aloe extract defends HCE cells from H2O2-induced injury possibly due its antioxidant and anti-inflammatory activity, indicating that eye drops containing aloe extract may be used as an adjunctive treatment for FECD." @default.
- W3129646006 created "2021-03-01" @default.
- W3129646006 creator A5000863770 @default.
- W3129646006 creator A5010245193 @default.
- W3129646006 creator A5026283915 @default.
- W3129646006 creator A5051725020 @default.
- W3129646006 creator A5059353158 @default.
- W3129646006 creator A5060772045 @default.
- W3129646006 creator A5073458708 @default.
- W3129646006 creator A5080680155 @default.
- W3129646006 date "2021-02-20" @default.
- W3129646006 modified "2023-10-14" @default.
- W3129646006 title "Health Potential of Aloe vera against Oxidative Stress Induced Corneal Damage: An “In Vitro” Study" @default.
- W3129646006 cites W1553328291 @default.
- W3129646006 cites W1981703791 @default.
- W3129646006 cites W1984483336 @default.
- W3129646006 cites W1985695558 @default.
- W3129646006 cites W1995960237 @default.
- W3129646006 cites W1999891390 @default.
- W3129646006 cites W2000125316 @default.
- W3129646006 cites W2003431583 @default.
- W3129646006 cites W2006150041 @default.
- W3129646006 cites W2006791822 @default.
- W3129646006 cites W2012152703 @default.
- W3129646006 cites W2015243552 @default.
- W3129646006 cites W2044468289 @default.
- W3129646006 cites W2046202498 @default.
- W3129646006 cites W2048710374 @default.
- W3129646006 cites W2050682997 @default.
- W3129646006 cites W2061894581 @default.
- W3129646006 cites W2067202485 @default.
- W3129646006 cites W2068317135 @default.
- W3129646006 cites W2075409420 @default.
- W3129646006 cites W2079678113 @default.
- W3129646006 cites W2083979198 @default.
- W3129646006 cites W2091726616 @default.
- W3129646006 cites W2097696206 @default.
- W3129646006 cites W2105253404 @default.
- W3129646006 cites W2119587875 @default.
- W3129646006 cites W2121117378 @default.
- W3129646006 cites W2136744389 @default.
- W3129646006 cites W2137383541 @default.
- W3129646006 cites W2142622325 @default.
- W3129646006 cites W2190536356 @default.
- W3129646006 cites W2229105716 @default.
- W3129646006 cites W2399155895 @default.
- W3129646006 cites W2411430321 @default.
- W3129646006 cites W2416955451 @default.
- W3129646006 cites W2512624221 @default.
- W3129646006 cites W2513291255 @default.
- W3129646006 cites W2570576773 @default.
- W3129646006 cites W2591225817 @default.
- W3129646006 cites W2744657202 @default.
- W3129646006 cites W2772546906 @default.
- W3129646006 cites W2791408448 @default.
- W3129646006 cites W2792668113 @default.
- W3129646006 cites W2799667091 @default.
- W3129646006 cites W2809507431 @default.
- W3129646006 cites W2879286079 @default.
- W3129646006 cites W2885865152 @default.
- W3129646006 cites W2892342446 @default.
- W3129646006 cites W2909533094 @default.
- W3129646006 cites W2949944408 @default.
- W3129646006 cites W2960896379 @default.
- W3129646006 cites W2965123441 @default.
- W3129646006 cites W2974055973 @default.
- W3129646006 cites W3010982019 @default.
- W3129646006 cites W3018897537 @default.
- W3129646006 cites W3035372083 @default.
- W3129646006 cites W952719179 @default.
- W3129646006 doi "https://doi.org/10.3390/antiox10020318" @default.
- W3129646006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7923787" @default.
- W3129646006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33672553" @default.
- W3129646006 hasPublicationYear "2021" @default.
- W3129646006 type Work @default.
- W3129646006 sameAs 3129646006 @default.
- W3129646006 citedByCount "13" @default.
- W3129646006 countsByYear W31296460062021 @default.
- W3129646006 countsByYear W31296460062022 @default.
- W3129646006 countsByYear W31296460062023 @default.
- W3129646006 crossrefType "journal-article" @default.
- W3129646006 hasAuthorship W3129646006A5000863770 @default.
- W3129646006 hasAuthorship W3129646006A5010245193 @default.
- W3129646006 hasAuthorship W3129646006A5026283915 @default.
- W3129646006 hasAuthorship W3129646006A5051725020 @default.
- W3129646006 hasAuthorship W3129646006A5059353158 @default.
- W3129646006 hasAuthorship W3129646006A5060772045 @default.
- W3129646006 hasAuthorship W3129646006A5073458708 @default.
- W3129646006 hasAuthorship W3129646006A5080680155 @default.
- W3129646006 hasBestOaLocation W31296460061 @default.
- W3129646006 hasConcept C185592680 @default.
- W3129646006 hasConcept C190283241 @default.
- W3129646006 hasConcept C2775838275 @default.
- W3129646006 hasConcept C2776151105 @default.
- W3129646006 hasConcept C2778004101 @default.
- W3129646006 hasConcept C2778401633 @default.
- W3129646006 hasConcept C2778979269 @default.
- W3129646006 hasConcept C2779404486 @default.