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- W3129652120 abstract "For successful signaling, Ras associates with its downstream effector, Raf. Ras dimerization likely plays an important role in this process, as the active form of Raf is known to be a dimer. However, it is still unclear whether Ras dimerizes first, facilitating the Raf dimerization and further downstream signaling, or a different sequence of events is in play. Given the conformational heterogeneity in both Ras and Raf, probing their dimerization mechanism experimentally is difficult. Hence, we used simulations and deep learning methods to characterize the Ras dimerization interface." @default.
- W3129652120 created "2021-03-01" @default.
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- W3129652120 date "2021-02-01" @default.
- W3129652120 modified "2023-09-25" @default.
- W3129652120 title "Deep Learning Reveals Wild-Type and Mutant RAS Dimer Interface Formation in Membranes" @default.
- W3129652120 doi "https://doi.org/10.1016/j.bpj.2020.11.1544" @default.
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