Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129744915> ?p ?o ?g. }
- W3129744915 abstract "Abstract Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation therapy is limited by normal-tissue damage including kidney toxicity. Different thresholds for kidney toxicity exist for different entities of RT. Histopathologic features of RN include vascular, glomerular and tubulointerstitial damage. The different molecular and cellular pathomechanisms involved in RN are not fully understood. Ionizing radiation causes double-stranded breaks in the DNA, followed by cell death including apoptosis and necrosis of renal endothelial, tubular and glomerular cells. Especially in the latent phase of RN oxidative stress and inflammation have been proposed as putative pathomechanisms, but so far no clear evidence was found. Cellular senescence, activation of the renin–angiotensin–aldosterone-system and vascular dysfunction might contribute to RN, but only limited data is available. Several signalling pathways have been identified in animal models of RN and different approaches to mitigate RN have been investigated. Drugs that attenuate cell death and inflammation or reduce oxidative stress and renal fibrosis were tested. Renin–angiotensin–aldosterone-system blockade, anti-apoptotic drugs, statins, and antioxidants have been shown to reduce the severity of RN. These results provide a rationale for the development of new strategies to prevent or reduce radiation-induced kidney toxicity." @default.
- W3129744915 created "2021-03-01" @default.
- W3129744915 creator A5035895613 @default.
- W3129744915 creator A5065547065 @default.
- W3129744915 creator A5075849331 @default.
- W3129744915 date "2021-02-25" @default.
- W3129744915 modified "2023-10-18" @default.
- W3129744915 title "Radiation-induced kidney toxicity: molecular and cellular pathogenesis" @default.
- W3129744915 cites W127809968 @default.
- W3129744915 cites W1525743162 @default.
- W3129744915 cites W1864661279 @default.
- W3129744915 cites W1959334052 @default.
- W3129744915 cites W1968890803 @default.
- W3129744915 cites W1969223713 @default.
- W3129744915 cites W1977199347 @default.
- W3129744915 cites W1981963429 @default.
- W3129744915 cites W1985144544 @default.
- W3129744915 cites W1985883447 @default.
- W3129744915 cites W1991003969 @default.
- W3129744915 cites W1992206118 @default.
- W3129744915 cites W1995911621 @default.
- W3129744915 cites W1997367417 @default.
- W3129744915 cites W2007216356 @default.
- W3129744915 cites W2013098479 @default.
- W3129744915 cites W2017811188 @default.
- W3129744915 cites W2018154498 @default.
- W3129744915 cites W2021749744 @default.
- W3129744915 cites W2024754526 @default.
- W3129744915 cites W2031048655 @default.
- W3129744915 cites W2031465902 @default.
- W3129744915 cites W2032522939 @default.
- W3129744915 cites W2035296797 @default.
- W3129744915 cites W2035919283 @default.
- W3129744915 cites W2037314608 @default.
- W3129744915 cites W2038452073 @default.
- W3129744915 cites W2046701188 @default.
- W3129744915 cites W2049137993 @default.
- W3129744915 cites W2051645076 @default.
- W3129744915 cites W2053641691 @default.
- W3129744915 cites W2056194572 @default.
- W3129744915 cites W2061402117 @default.
- W3129744915 cites W2074730941 @default.
- W3129744915 cites W2083499302 @default.
- W3129744915 cites W2084569840 @default.
- W3129744915 cites W2089861955 @default.
- W3129744915 cites W2090803169 @default.
- W3129744915 cites W2097512974 @default.
- W3129744915 cites W2097942030 @default.
- W3129744915 cites W2101833366 @default.
- W3129744915 cites W2102508479 @default.
- W3129744915 cites W2104073675 @default.
- W3129744915 cites W2106323108 @default.
- W3129744915 cites W2108579114 @default.
- W3129744915 cites W2110297459 @default.
- W3129744915 cites W2122971805 @default.
- W3129744915 cites W2126106255 @default.
- W3129744915 cites W2136716437 @default.
- W3129744915 cites W2137642415 @default.
- W3129744915 cites W2140173755 @default.
- W3129744915 cites W2144139718 @default.
- W3129744915 cites W2145133023 @default.
- W3129744915 cites W2146498297 @default.
- W3129744915 cites W2150724109 @default.
- W3129744915 cites W2150748567 @default.
- W3129744915 cites W2151252396 @default.
- W3129744915 cites W2156257249 @default.
- W3129744915 cites W2160314446 @default.
- W3129744915 cites W2198709783 @default.
- W3129744915 cites W2212776653 @default.
- W3129744915 cites W2273736591 @default.
- W3129744915 cites W2283085523 @default.
- W3129744915 cites W2315168906 @default.
- W3129744915 cites W2342679639 @default.
- W3129744915 cites W2508810130 @default.
- W3129744915 cites W2510662304 @default.
- W3129744915 cites W2593910489 @default.
- W3129744915 cites W2599868774 @default.
- W3129744915 cites W2605641002 @default.
- W3129744915 cites W2607436265 @default.
- W3129744915 cites W2608236935 @default.
- W3129744915 cites W2621172390 @default.
- W3129744915 cites W2766227115 @default.
- W3129744915 cites W2772570025 @default.
- W3129744915 cites W2781280605 @default.
- W3129744915 cites W2792996990 @default.
- W3129744915 cites W2799848443 @default.
- W3129744915 cites W2804880211 @default.
- W3129744915 cites W2886076351 @default.
- W3129744915 cites W2889646458 @default.
- W3129744915 cites W2890247245 @default.
- W3129744915 cites W2899962460 @default.
- W3129744915 cites W2909677140 @default.
- W3129744915 cites W2914280170 @default.
- W3129744915 cites W2936177944 @default.
- W3129744915 cites W2948831484 @default.
- W3129744915 cites W2965260012 @default.
- W3129744915 cites W2971454466 @default.
- W3129744915 cites W2985431943 @default.
- W3129744915 cites W2989222572 @default.
- W3129744915 cites W3006609143 @default.