Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129749589> ?p ?o ?g. }
- W3129749589 endingPage "2184" @default.
- W3129749589 startingPage "2173" @default.
- W3129749589 abstract "Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal fibrosis and oral squamous cell carcinoma (OSCC), however the mechanism remains unclear. The aim of this study was to establish an arecoline-induced epithelial-mesenchymal transformation (EMT) model of OSCC cells and to investigate the underlying mechanisms. CAL33 and UM2 cells were induced with arecoline to establish an EMT cell model and perform RNA-sequence screening. Luminex multiplex cytokine assays, western blot, and RT-qPCR were used to investigate the EMT mechanism. Arecoline at a concentration of 160 μg/ml was used to induce EMT in OSCC cells, which was confirmed using morphological analysis, transwell assays, and EMT marker detection. RNA-sequence screening and Luminex multiplex cytokine assays showed that many inflammatory cytokines (such as serum amyloid A1 [SAA1], interleukin [IL]-6, IL-36G, chemokine [CCL]2, and CCL20) were significantly altered during arecoline-induced EMT. Of these cytokines, SAA1 was the most highly upregulated. SAA1 overexpression induced EMT and promoted the migration and invasion of CAL33 cells, while SAA1 knockdown attenuated arecoline-induced EMT. Moreover, arecoline enhanced cervical lymph node metastasis in an orthotopic xenograft model of the tongue established using BALB/c nude mice. Our findings revealed that arecoline induced EMT and enhanced the metastatic capability of OSCC by the regulation of inflammatory cytokine secretion, especially that of SAA1. Our study provides a basis for understanding the mechanism of OSCC metastasis and suggests possible therapeutic targets to prevent the occurrence and development of OSCC associated with areca nut chewing." @default.
- W3129749589 created "2021-03-01" @default.
- W3129749589 creator A5016189422 @default.
- W3129749589 creator A5016469030 @default.
- W3129749589 creator A5032769690 @default.
- W3129749589 creator A5044411516 @default.
- W3129749589 creator A5052699986 @default.
- W3129749589 creator A5056753220 @default.
- W3129749589 creator A5065912071 @default.
- W3129749589 creator A5078790196 @default.
- W3129749589 creator A5083695708 @default.
- W3129749589 date "2021-05-01" @default.
- W3129749589 modified "2023-10-16" @default.
- W3129749589 title "Retracted: Arecoline induces epithelial‐mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression" @default.
- W3129749589 cites W1520881062 @default.
- W3129749589 cites W1969444967 @default.
- W3129749589 cites W1994081610 @default.
- W3129749589 cites W1994659397 @default.
- W3129749589 cites W2040895094 @default.
- W3129749589 cites W2082494096 @default.
- W3129749589 cites W2171440607 @default.
- W3129749589 cites W2272984102 @default.
- W3129749589 cites W2288795997 @default.
- W3129749589 cites W2325714288 @default.
- W3129749589 cites W2505101453 @default.
- W3129749589 cites W2587934921 @default.
- W3129749589 cites W2588314681 @default.
- W3129749589 cites W2594909700 @default.
- W3129749589 cites W2618856057 @default.
- W3129749589 cites W2735796748 @default.
- W3129749589 cites W2768188655 @default.
- W3129749589 cites W2768566750 @default.
- W3129749589 cites W2771871673 @default.
- W3129749589 cites W2786843484 @default.
- W3129749589 cites W2804996860 @default.
- W3129749589 cites W2890167667 @default.
- W3129749589 cites W2906067435 @default.
- W3129749589 cites W2911188335 @default.
- W3129749589 cites W2940443381 @default.
- W3129749589 cites W2941277688 @default.
- W3129749589 cites W2999832308 @default.
- W3129749589 cites W3013647280 @default.
- W3129749589 cites W3027766543 @default.
- W3129749589 cites W3032948371 @default.
- W3129749589 cites W3034999789 @default.
- W3129749589 cites W3035945602 @default.
- W3129749589 cites W3041939827 @default.
- W3129749589 cites W3049092055 @default.
- W3129749589 cites W3082099344 @default.
- W3129749589 cites W3089945227 @default.
- W3129749589 doi "https://doi.org/10.1111/cas.14866" @default.
- W3129749589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8177782" @default.
- W3129749589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33626219" @default.
- W3129749589 hasPublicationYear "2021" @default.
- W3129749589 type Work @default.
- W3129749589 sameAs 3129749589 @default.
- W3129749589 citedByCount "19" @default.
- W3129749589 countsByYear W31297495892021 @default.
- W3129749589 countsByYear W31297495892022 @default.
- W3129749589 countsByYear W31297495892023 @default.
- W3129749589 crossrefType "journal-article" @default.
- W3129749589 hasAuthorship W3129749589A5016189422 @default.
- W3129749589 hasAuthorship W3129749589A5016469030 @default.
- W3129749589 hasAuthorship W3129749589A5032769690 @default.
- W3129749589 hasAuthorship W3129749589A5044411516 @default.
- W3129749589 hasAuthorship W3129749589A5052699986 @default.
- W3129749589 hasAuthorship W3129749589A5056753220 @default.
- W3129749589 hasAuthorship W3129749589A5065912071 @default.
- W3129749589 hasAuthorship W3129749589A5078790196 @default.
- W3129749589 hasAuthorship W3129749589A5083695708 @default.
- W3129749589 hasBestOaLocation W31297495891 @default.
- W3129749589 hasConcept C121608353 @default.
- W3129749589 hasConcept C126322002 @default.
- W3129749589 hasConcept C170493617 @default.
- W3129749589 hasConcept C203014093 @default.
- W3129749589 hasConcept C2778690821 @default.
- W3129749589 hasConcept C2779013556 @default.
- W3129749589 hasConcept C2781277053 @default.
- W3129749589 hasConcept C33789571 @default.
- W3129749589 hasConcept C502942594 @default.
- W3129749589 hasConcept C555283112 @default.
- W3129749589 hasConcept C71924100 @default.
- W3129749589 hasConceptScore W3129749589C121608353 @default.
- W3129749589 hasConceptScore W3129749589C126322002 @default.
- W3129749589 hasConceptScore W3129749589C170493617 @default.
- W3129749589 hasConceptScore W3129749589C203014093 @default.
- W3129749589 hasConceptScore W3129749589C2778690821 @default.
- W3129749589 hasConceptScore W3129749589C2779013556 @default.
- W3129749589 hasConceptScore W3129749589C2781277053 @default.
- W3129749589 hasConceptScore W3129749589C33789571 @default.
- W3129749589 hasConceptScore W3129749589C502942594 @default.
- W3129749589 hasConceptScore W3129749589C555283112 @default.
- W3129749589 hasConceptScore W3129749589C71924100 @default.
- W3129749589 hasIssue "6" @default.
- W3129749589 hasLocation W31297495891 @default.
- W3129749589 hasLocation W31297495892 @default.
- W3129749589 hasOpenAccess W3129749589 @default.
- W3129749589 hasPrimaryLocation W31297495891 @default.