Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129756526> ?p ?o ?g. }
- W3129756526 endingPage "261" @default.
- W3129756526 startingPage "255" @default.
- W3129756526 abstract "Purpose of review This review aims to bring together recent advances in basic, translational and clinical research on the pathogenesis and treatment of orbital inflammatory conditions. Recent findings Basic science studies provide mechanistic insights into why the orbit is targeted for inflammation by autoimmune inflammatory disorders. Using Graves' disease as a test case reveals that endocrine pathways, such as the TSH and IGF1 receptor pathways play important roles in stimulating orbital inflammation. Furthermore, orbital tissues contain high concentrations of retinoids - byproducts of the visual pathway that diffuse across the sclera and can activate de novo transcription of inflammatory cytokines. Such cytokine expression places the orbit in a hyper-inflammatory 'resting' state, prone to respond to any additional systemic or local pro-inflammatory signals. The HIF2A--LOX pathway appears important for orbital tissue fibrosis. Lastly, bench-to-bedside studies of the IGF1R pathway have led to an FDA-approved drug, teprotumumab that represents a novel treatment approach for Graves' orbitopathy. Unfortunately, high drug costs and misplaced insurance company 'step-therapy' policies may block patients from receiving therapy that can protect vision and improve quality of life. Summary Improved understanding of orbital inflammatory conditions has led to a new drug and promises additional breakthroughs. Translational research is successful, but requires time, resources, and patience." @default.
- W3129756526 created "2021-03-01" @default.
- W3129756526 creator A5090438267 @default.
- W3129756526 date "2021-02-16" @default.
- W3129756526 modified "2023-09-26" @default.
- W3129756526 title "Orbital inflammatory disorders: new knowledge, future challenges" @default.
- W3129756526 cites W1545794063 @default.
- W3129756526 cites W1566194239 @default.
- W3129756526 cites W1839228204 @default.
- W3129756526 cites W1921320868 @default.
- W3129756526 cites W1967732103 @default.
- W3129756526 cites W1974372293 @default.
- W3129756526 cites W1983165202 @default.
- W3129756526 cites W1986938885 @default.
- W3129756526 cites W1987627280 @default.
- W3129756526 cites W1991051577 @default.
- W3129756526 cites W1993852116 @default.
- W3129756526 cites W1994762998 @default.
- W3129756526 cites W2005031444 @default.
- W3129756526 cites W2007453696 @default.
- W3129756526 cites W2010718447 @default.
- W3129756526 cites W2012440149 @default.
- W3129756526 cites W2013284550 @default.
- W3129756526 cites W2014603807 @default.
- W3129756526 cites W2017785146 @default.
- W3129756526 cites W2018732743 @default.
- W3129756526 cites W2018846180 @default.
- W3129756526 cites W2021249974 @default.
- W3129756526 cites W2021677886 @default.
- W3129756526 cites W2024010187 @default.
- W3129756526 cites W2025698710 @default.
- W3129756526 cites W2037715097 @default.
- W3129756526 cites W2039880475 @default.
- W3129756526 cites W2041058797 @default.
- W3129756526 cites W2042924921 @default.
- W3129756526 cites W2046208657 @default.
- W3129756526 cites W2050157087 @default.
- W3129756526 cites W2050740094 @default.
- W3129756526 cites W2056222602 @default.
- W3129756526 cites W2060860673 @default.
- W3129756526 cites W2069075566 @default.
- W3129756526 cites W2075324729 @default.
- W3129756526 cites W2079958505 @default.
- W3129756526 cites W2081212738 @default.
- W3129756526 cites W2081929389 @default.
- W3129756526 cites W2090854156 @default.
- W3129756526 cites W2092040763 @default.
- W3129756526 cites W2092055418 @default.
- W3129756526 cites W2093134054 @default.
- W3129756526 cites W2104440580 @default.
- W3129756526 cites W2109005905 @default.
- W3129756526 cites W2120808032 @default.
- W3129756526 cites W2123949520 @default.
- W3129756526 cites W2125825685 @default.
- W3129756526 cites W2137390873 @default.
- W3129756526 cites W2141351444 @default.
- W3129756526 cites W2143018322 @default.
- W3129756526 cites W2144925285 @default.
- W3129756526 cites W2145826431 @default.
- W3129756526 cites W2147249742 @default.
- W3129756526 cites W2151135812 @default.
- W3129756526 cites W2153640804 @default.
- W3129756526 cites W2155802820 @default.
- W3129756526 cites W2156245995 @default.
- W3129756526 cites W2156593644 @default.
- W3129756526 cites W2163962800 @default.
- W3129756526 cites W2167827661 @default.
- W3129756526 cites W2170556033 @default.
- W3129756526 cites W2218371886 @default.
- W3129756526 cites W2288910126 @default.
- W3129756526 cites W2290271902 @default.
- W3129756526 cites W2313063314 @default.
- W3129756526 cites W2317071774 @default.
- W3129756526 cites W2319941979 @default.
- W3129756526 cites W2324496208 @default.
- W3129756526 cites W2325293608 @default.
- W3129756526 cites W2327021476 @default.
- W3129756526 cites W2427997302 @default.
- W3129756526 cites W2467352350 @default.
- W3129756526 cites W2515771386 @default.
- W3129756526 cites W2550257036 @default.
- W3129756526 cites W2611131029 @default.
- W3129756526 cites W2733248242 @default.
- W3129756526 cites W2755710197 @default.
- W3129756526 cites W2786512781 @default.
- W3129756526 cites W2787763552 @default.
- W3129756526 cites W2789696553 @default.
- W3129756526 cites W2884785158 @default.
- W3129756526 cites W2886813142 @default.
- W3129756526 cites W2891816059 @default.
- W3129756526 cites W2899206084 @default.
- W3129756526 cites W2899444928 @default.
- W3129756526 cites W2914871644 @default.
- W3129756526 cites W2944926562 @default.
- W3129756526 cites W2947965751 @default.
- W3129756526 cites W2975789126 @default.
- W3129756526 cites W2982634863 @default.
- W3129756526 cites W2983185977 @default.