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- W3129795230 abstract "The oral route is the most widely used path for drug administration, since it is the safest and most comfortable for patients, resulting in better adherence to treatments. Despite the inherent and undeniable advantages of this route, important limitations of its use should be considered, specifically those related to solubility, stability, permeability, and/or absorption of drugs and/or biomolecules throughout the different environments of the gastrointestinal tract (GIT), which can consequently affect bioavailability and the therapeutic effect. Important technological strategies have been explored over recent years, which aim to solve such challenges and enable oral administration even of drugs with potential limitations. Among such strategies, compartmentalizing molecules into nanoscale structures has shown to be a rational and promising tool for reaching the aforementioned goal. In addition to protecting the drug and/or biomolecule in the different environments of the GIT, drug entrapment into nanostructures can provide important advantages inherent to their reduced dimensions, such as increased permeability and diffusion into biological membranes, as well as the possibility of cellular internalization. Furthermore, the properties of materials employed in the design of these nanostructured drug release systems should drive their general properties. Characteristics such as bio/mucoadhesion, swelling, and stimuli sensitivity can be tailored for specific biological conditions. In this chapter, we will address insights about the design of different nano-sized drug release systems, such as polymeric nanoparticles, solid lipid nanoparticles, nanosuspensions, liposomes, micelles, and dendrimers. The most important aspects of using such oral release systems for drugs and/or biomolecules will be presented." @default.
- W3129795230 created "2021-03-01" @default.
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- W3129795230 creator A5068351479 @default.
- W3129795230 date "2021-01-01" @default.
- W3129795230 modified "2023-10-01" @default.
- W3129795230 title "Nanocarriers for Oral Drug Delivery" @default.
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- W3129795230 doi "https://doi.org/10.1007/978-3-030-63389-9_7" @default.
- W3129795230 hasPublicationYear "2021" @default.
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