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- W3129851444 abstract "Published descriptions of the neuropathology of clinically defined primary lateral sclerosis (PLS) are reviewed in order to clarify the pathogenesis and the relationship between PLS and classical amyotrophic lateral sclerosis (ALS). Degeneration of the primary motor cortex and corticospinal tracts with preservation of lower motor neurons (LMN) has been reported in most cases. Studies that employed immunohistochemistry found ubiquitin and/or TDP-43-positive neuronal inclusions in the motor cortex and often in the extramotor neocortex. Ubiquitin/TDP-43-immunoreactive inclusions in LMN have been reported in just over half of cases; however, these have never been numerous. The finding of TDP-43 pathology in most cases indicates that PLS and ALS are closely related conditions; however, the fact that cases of PLS consistently show minimal involvement of LMN suggests that PLS represents a distinct entity, rather than an early stage of ALS." @default.
- W3129851444 created "2021-03-01" @default.
- W3129851444 creator A5053377589 @default.
- W3129851444 date "2020-11-02" @default.
- W3129851444 modified "2023-09-30" @default.
- W3129851444 title "Neuropathology of primary lateral sclerosis" @default.
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- W3129851444 doi "https://doi.org/10.1080/21678421.2020.1837173" @default.
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