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- W3129874419 endingPage "559" @default.
- W3129874419 startingPage "543" @default.
- W3129874419 abstract "tRNAs undergo an extensive maturation process including posttranscriptional modifications that influence secondary and tertiary interactions. Precursor and mature tRNAs lacking key modifications are often recognized as aberrant and subsequently targeted for decay, illustrating the importance of modifications in promoting structural integrity. tRNAs also rely on tRNA chaperones to promote the folding of misfolded substrates into functional conformations. The best characterized tRNA chaperone is the La protein, which interacts with nascent RNA polymerase III transcripts to promote folding and offers protection from exonucleases. More recently, certain tRNA modification enzymes have also been demonstrated to possess tRNA folding activity distinct from their catalytic activity, suggesting that they may act as tRNA chaperones. In this review, we will discuss pioneering studies relating posttranscriptional modification to tRNA stability and decay pathways, present recent advances into the mechanism by which the RNA chaperone La assists pre-tRNA maturation, and summarize emerging research directions aimed at characterizing modification enzymes as tRNA chaperones. Together, these findings shed light on the importance of tRNA folding and how tRNA chaperones, in particular, increase the fraction of nascent pre-tRNAs that adopt a folded, functional conformation." @default.
- W3129874419 created "2021-03-01" @default.
- W3129874419 creator A5049463463 @default.
- W3129874419 creator A5052087068 @default.
- W3129874419 creator A5067086353 @default.
- W3129874419 date "2021-02-16" @default.
- W3129874419 modified "2023-10-14" @default.
- W3129874419 title "Revisiting tRNA chaperones: new players in an ancient game" @default.
- W3129874419 cites W1562507949 @default.
- W3129874419 cites W1622955452 @default.
- W3129874419 cites W1966454532 @default.
- W3129874419 cites W1966478595 @default.
- W3129874419 cites W1968321573 @default.
- W3129874419 cites W1969122871 @default.
- W3129874419 cites W1973021684 @default.
- W3129874419 cites W1973290333 @default.
- W3129874419 cites W1976732266 @default.
- W3129874419 cites W1978486300 @default.
- W3129874419 cites W1978856165 @default.
- W3129874419 cites W1979239458 @default.
- W3129874419 cites W1979880724 @default.
- W3129874419 cites W1983487158 @default.
- W3129874419 cites W1987777159 @default.
- W3129874419 cites W1988309554 @default.
- W3129874419 cites W1988747387 @default.
- W3129874419 cites W1989653036 @default.
- W3129874419 cites W1991816366 @default.
- W3129874419 cites W1992416271 @default.
- W3129874419 cites W1993475731 @default.
- W3129874419 cites W1994926187 @default.
- W3129874419 cites W1996351611 @default.
- W3129874419 cites W2000293147 @default.
- W3129874419 cites W2002603819 @default.
- W3129874419 cites W2003049655 @default.
- W3129874419 cites W2005418948 @default.
- W3129874419 cites W2005420540 @default.
- W3129874419 cites W2007982521 @default.
- W3129874419 cites W2014056463 @default.
- W3129874419 cites W2019832209 @default.
- W3129874419 cites W2026334893 @default.
- W3129874419 cites W2027143159 @default.
- W3129874419 cites W2029130204 @default.
- W3129874419 cites W2029494510 @default.
- W3129874419 cites W2031388575 @default.
- W3129874419 cites W2032669220 @default.
- W3129874419 cites W2034145179 @default.
- W3129874419 cites W2036116609 @default.
- W3129874419 cites W2038941135 @default.
- W3129874419 cites W2039243132 @default.
- W3129874419 cites W2041044381 @default.
- W3129874419 cites W2043924890 @default.
- W3129874419 cites W2044386270 @default.
- W3129874419 cites W2047689300 @default.
- W3129874419 cites W2048322955 @default.
- W3129874419 cites W2050647031 @default.
- W3129874419 cites W2052781521 @default.
- W3129874419 cites W2052946180 @default.
- W3129874419 cites W2053797100 @default.
- W3129874419 cites W2053811298 @default.
- W3129874419 cites W2056381504 @default.
- W3129874419 cites W2056837963 @default.
- W3129874419 cites W2064075969 @default.
- W3129874419 cites W2069169076 @default.
- W3129874419 cites W2071529347 @default.
- W3129874419 cites W2072734582 @default.
- W3129874419 cites W2072927794 @default.
- W3129874419 cites W2074518174 @default.
- W3129874419 cites W2078673786 @default.
- W3129874419 cites W2089004878 @default.
- W3129874419 cites W2089825698 @default.
- W3129874419 cites W2090432575 @default.
- W3129874419 cites W2091911427 @default.
- W3129874419 cites W2092458834 @default.
- W3129874419 cites W2100926646 @default.
- W3129874419 cites W2102406695 @default.
- W3129874419 cites W2107622595 @default.
- W3129874419 cites W2108203291 @default.
- W3129874419 cites W2108376871 @default.
- W3129874419 cites W2109566621 @default.
- W3129874419 cites W2112765717 @default.
- W3129874419 cites W2112815967 @default.
- W3129874419 cites W2113039254 @default.
- W3129874419 cites W2113263393 @default.
- W3129874419 cites W2114433875 @default.
- W3129874419 cites W2114478647 @default.
- W3129874419 cites W2115208078 @default.
- W3129874419 cites W2116361747 @default.
- W3129874419 cites W2118810495 @default.
- W3129874419 cites W2119312493 @default.
- W3129874419 cites W2119774438 @default.
- W3129874419 cites W2119909859 @default.
- W3129874419 cites W2122208807 @default.
- W3129874419 cites W2123657381 @default.
- W3129874419 cites W2123893396 @default.
- W3129874419 cites W2128098883 @default.
- W3129874419 cites W2132315340 @default.
- W3129874419 cites W2135392625 @default.
- W3129874419 cites W2135579665 @default.